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Septins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions.
This book comprehensively examines the septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including C. elegans and Drosophila.
A major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed.
In addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences.
This book is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.
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John Maynard Keynes once observed that the "ideas of economists and political philosophers, both when they are right and when they are wrong, are more powerful than is commonly understood." The contributors to this volume take that assertion seriously. In a full-scale study of the impact of Keynesian doctrines across nations, their essays trace the reception accorded Keynesian ideas, initially during the 1930s and then in the years after World War II, in a wide range of nations, including Britain, the United States, France, Germany, Italy, Japan, and Scandinavia. The contributors review the latest historical evidence to explain why some nations embraced Keynesian policies while others did not. At a time of growing interest in comparative public policy-making, they examine the central issue of how and why particular ideas acquire influence over policy and politics. Based on three years of collaborative research for the Social Science Research Council, the volume takes up central themes in contemporary economics, political science, and history. The contributors are Christopher S. Allen, Marcello de Cecco, Peter Alexis Gourevitch, Eleanor M. Hadley, Peter A. Hall, Albert O. Hirschman, Harold James, Bradford A. Lee, Jukka Pekkarinen, Pierre Rosanvallon, Walter S. Salant, Margaret Weir, and Donald Winch.
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