Steven Holland – författare

The acclaimed, landmark guide to internal medicine—updated to reflect the latest guidelines and recommendations  The Voice of Clinical ReasonA Doody's Core Title for 2026!For more than seven decades, Harrison’s Principles of Internal Medicine has provided healthcare professionals with the informational foundation needed to provide optimal patient care. The world’s leading authority on applied pathophysiology and clinical medicine, this trusted resource has covered countless advances and developments across the full span of medicine. Fully updated, the new 22nd edition has been modified extensively in its structure and content and offers a standardized format for each disease chapter. The authors and editors have curated and synthesized the vast amount of information that comprises general internal medicine and each of the major specialties into a highly readable and informative resource. Harrison’s is world-renowned as the most authoritative source for: •  Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases •    Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases•    The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow•    Updated clinical trial results and recommended guidelines•    Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings•    Coverage of both therapeutic approaches and specific treatment regimens•    Practical clinical decision trees and algorithms•    Organ- and system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, as well as general and specific approaches to therapyThis twenty-second edition features:•    Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries•    More than 3,000, clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes•    Numerous atlases featuring curated collections of important visual aspects of diagnosis and management•    Brand new chapters, including The Value of the Physical Examination in Modern Medicine, Physician Well-Being, Exercise Intolerance, Primary and Secondary Hemophagocytic Lymphohistiocytosis, Symptom Control in Patients with Cancer, Principles of Immunization, COVID and Other Coronavirus Infections, Desensitization, Point-of-Care Ultrasound, Placebo and Nocebo Effects, Bedside Examination Tests in the Patient with Low Back Pain, and Antithrombotic Therapy in Adult Patients

Whether the fossil record should be read at face value or whether it presents a distorted view of the history of life is an argument seemingly as old as many fossils themselves. In the late 1700s, Georges Cuvier argued for a literal interpretation, but in the early 1800s, Charles Lyell's gradualist view of the earth's history required a more nuanced interpretation of that same record. To this day, the tension between literal and interpretive readings lies at the heart of paleontological research, influencing the way scientists view extinction patterns and their causes, eco-system persistence and turnover, and the pattern of morphologic change and mode of speciation. With "Stratigraphic Paleobiology", Mark E. Patzkowsky and Steven M. Holland present a critical framework for assessing the fossil record, one based on a modern understanding of the principles of sediment accumulation. Patzkowsky and Holland argue that the distribution of fossil taxa in time and space is controlled not only by processes of ecology, evolution, and environmental change, but also by the stratigraphic processes that govern where and when sediment that might contain fossils is deposited and preserved.The authors explore the exciting possibilities of stratigraphic paleobiology, and along the way demonstrate its great potential to answer some of the most critical questions about the history of life.

The principles of stratigraphic paleobiology can be readily applied to the nonmarine fossil record. Consistent spatial and temporal patterns of accommodation and sedimentation in sedimentary basins are an important control on stratigraphic architecture. Temperature and precipitation covary with elevation, causing significant variation in community composition, and changes in base level cause elevation to undergo predictable changes. These principles lead to eight sets of hypotheses about the nonmarine fossil record. Three relate to long-term and cyclical patterns in the preservation of major fossil groups and their taphonomy, as well as the occurrence of fossil concentrations. The remaining hypotheses relate to the widespread occurrence of elevation-correlated gradients in community composition, long-term and cyclical trends in these communities, and the stratigraphic position of abrupt changes in community composition. Testing of these hypotheses makes the stratigraphic paleobiology of nonmarine systems a promising area of investigation.

The principles of stratigraphic paleobiology can be readily applied to the nonmarine fossil record. Consistent spatial and temporal patterns of accommodation and sedimentation in sedimentary basins are an important control on stratigraphic architecture. Temperature and precipitation covary with elevation, causing significant variation in community composition, and changes in base level cause elevation to undergo predictable changes. These principles lead to eight sets of hypotheses about the nonmarine fossil record. Three relate to long-term and cyclical patterns in the preservation of major fossil groups and their taphonomy, as well as the occurrence of fossil concentrations. The remaining hypotheses relate to the widespread occurrence of elevation-correlated gradients in community composition, long-term and cyclical trends in these communities, and the stratigraphic position of abrupt changes in community composition. Testing of these hypotheses makes the stratigraphic paleobiology of nonmarine systems a promising area of investigation.