Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy – serie

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.

Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward.The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics.This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping.

Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy.

Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients.

Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective.

Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

Principles of Immunotherapy in Breast and Gastrointestinal Cancers: Activity, Mechanisms of Resistance, and New Sensitization Strategies presents updated research findings on immunotherapy, with a special focus on the mechanisms of resistance of those cancer types and how to overcome them.The book discusses topics such as tumor cell-intrinsic and -extrinsic mechanisms of cancer resistance to immunotherapy; the role of currently available biomarkers; strategies to overcome therapeutic resistance; sensitizing agents for cancer resistance to cell-mediated immunotherapy; and immunotherapeutic approaches, mechanisms of resistance, and sensitizing strategies in gastroesophageal and biliopancreatic tumors and colorectal cancer.It is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about resistance to immunotherapy and how to overcome it.

Presents relevant findings on immunotherapy for breast and GI cancer types in a synthetic and didactic way for easy consultDescribes resistance mechanisms of those cancer types and how to overcome them to improve immunotherapy outcomesEncompasses several diagrams and figures to help readers get a clearer picture of the research findings and how they can be applied to the clinical setting

T Cell Metabolism and Cancer Immunotherapy delves into the intricate regulation of T-cell immunity and tolerance. As research advances in cell-based therapies, the potential of engineered immune cells to treat cancers and other diseases is becoming increasingly evident due to their powerful capabilities. Additionally, the book offers valuable insights into developing and optimizing strategies for bacterium-based immunotherapies. Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy. By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity. Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy.

Provides a summary of the current state-of-the-art, creating a valuable foundation for both established researchers and newcomers/students in the field in cancer immunotherapies Focuses on the investigation of cellular regulation of T-cell immunity and toleranceDefines the precise role and mechanism of T cell metabolism in modulating T cells and T cell-mediated immunity

?? T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical ?? T cell immunotherapy landscape.In five chapters, field experts discuss the challenges facing ?? T cell oncoimmunotherapy, propose solutions, and map next steps.Particular attention is given to summarizing our understanding of the complex, translationally relevant human ?? T cell biology, the evidence basis for designing ?? T cell combination trials and data-driven perspectives on what is known-and what isn’t-about ?? T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering.A chapter is dedicated to the systematic review of all ?? T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of ?? T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering.?? T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of ??T cell immunotherapy, which is of interest to existing translational ?? T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter ?? T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

Summarizes the cutting edge of oncology-relevant ?? T cell immunobiologyLays out clinical successes and failures to dateAddresses the possible advantage of combining ?? T cell-based immunotherapy with conventional chemotherapy or checkpoint blockersProvides an up-to-date and well-rounded discussion of a translationally, commercially, and scientifically relevant field

Gammadelta T cells in Cancer Immunotherapy shows how the potential of ?d T-cells can effectively be translated into clinical benefit in cancer immunotherapies. With a strong focus on finding alternatives to current T cell mediated cancer immunotherapies, the book can also be used as a baseline initial introduction to the field of gamma delta immunotherapy. In 13 chapters Gammadelta T cells in cancer immunotherapy describes different approaches to a specific model of gammadelta immunotherapy including ‘delta one T’ (DOT) and Allogeneic CAR. It describes the rationale for the use of gamma delta cells in immunotherapy, strategies, therapies, and cancer treatment. Gammadelta T cells in Cancer Immunotherapy answers the growing interest in the scientific and medical community in general immunotherapy and familiarizes end users with the basic biology of gammadelta T cells, the pre-clinical studies implying their utility in immunotherapy, and with the studies of clinical applications of different forms of gammadelta T cell immunotherapeutic. modalities. Contents will help both basic scientists and clinicians understand how to overcome hurdles inherent to current forms of CAR T cell immunotherapy

The Resistance of Cervical Cancer to Chemotherapy and its Reversal provides a holistic understanding of cervical cancer development, immune-evading mechanisms of HPV, immunotherapies available, methods to study cervical cancer and the development of newer drugs. Content shows the involvement of signaling pathways during chemoresistance in cervical cancer, the involvement of genes in drug resistance, and introduces long noncoding RNAs as novel biomarkers.In 10 chapters, this book first provides an introduction and history of cervical cancer; next, it discusses the influence of viruses on cervical cancer and finally, it describes therapies to overcome chemotherapy resistance in cervical cancer. This is the perfect reference to provide the fundamental base of knowledge needed for oncologists, pharmacologists, translational investigators, immunotherapists, scientists, and clinicians interested in building a comprehensive understanding of the field.

Focuses on the aspects of cervical cancer resistance towards therapies such as chemoresistance and radioresistanceDiscusses the sensitizing agents that are being developed for the improvement of current therapies and better management of cervical cancerIdentifies the molecular mechanism of HPV integration and cervical cancer development