Ganji Purnachandra Nagaraju – författare

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy.

Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer.

Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer< Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines.

This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer for their research work or clinical setting.

Provides an updated literature review and detailed understanding of liver cancer tumor biology Discusses abnormal changes in the liver caused, resulting from, or associated with hepatocellular carcinoma from a holistic view Presents the content with fully colored images and summarizing tables for easy understanding of complex topics

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume Two: Diagnosis, Therapeutic Targets and Molecular Mechanisms for Hepatocellular Carcinoma Progression provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The volume discusses topics such as computational approaches for identification of biomarkers, enzymes and pathways of HCC, circulating and epigenetic biomarkers, drug resistance, metabolic pathways, and small molecule-target therapies. In addition, it discusses immunotherapies, immune check point inhibitors and nanotechnology-based therapies.

This book is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.

Provides detailed information on traditional and novel diagnostic tools for hepatocellular carcinoma Discusses promising targeted therapies, both available and in development, explaining the best option to use for specific cases Brings recent findings in immunotherapies, immune checkpoint inhibitors and nanotechnology-based therapeutic approaches for treatment of HCC

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma: Translational and Clinical Outcomes, Volume Three provides comprehensive information about ongoing research and clinical data on liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This updated volume discusses topics such as clinical and safety assessment of HCC patients, liver transplantation as a therapeutic option, immunotherapy interventions, and image-based surveillance. In addition, it discusses immunohistology of HCC-enabled precision medicine and artificial intelligence for hepatocellular carcinomas.

This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.

Provides best practices for the management of hepatocellular carcinoma in the clinical setting Discusses emerging treatment approaches based on artificial intelligence and precision medicine tools and techniques Brings updated information on international clinical trials for the treatment of HCC

Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability.

The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others.

This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients.

Discusses in silico remodeling of effective phytochemical compounds for discovering improved anticancer agents for substantial/significant cancer therapy Covers potential tools of bioinformatics that are applied toward discovering new targets by drug repurposing and strategies to cure different types of cancers Demonstrates the significance of computational and artificial intelligence approaches in anticancer drug discovery Explores how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Immune Landscape of Pancreatic Cancer Development and Drug Resistance explores advances in immune-based therapies aimed at harnessing the power of the immune system against pancreatic cancer and rewiring tumor microenvironments to eradicate pancreatic cells. With a strong focus on the development of therapeutic methods to improve the survival rates of pancreatic cancer, this book also shows the latest trends in immune targeted approaches for pancreatic cancer treatment. In 12 chapters, the book discusses our current understanding of PC development and its various mutational and immune features and explore some of the new immune-based therapies aimed at targeting pancreatic cancer. This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of advances in immunotherapy in pancreatic cancer.

Summarizes the potential combination strategies and latest clinical trials in pancreatic cancerProvides an in-depth overview of our current understanding of pancreatic cancer development, including its mutational and immune features Explores some of the new immune-based therapies aimed at targeting PCShows pancreatic cancer progression and basic elements in tumor microenvironments and their role in PC progression, also covering immunotherapy strategies

Immune Therapy for Pancreatic and Colon Cancer expands the knowledge on pathways, immune modulators, immune check points, and monoclonal antibodies that can lead to appropriate cancer treatment. With a strong focus on the development of immune therapies to improve the survival rates of pancreatic and colon cancer, this book also shows the latest trends in immune targeted approaches for cancer treatment. Sections describe the role of and the immune response to pancreatic and colon cancer, gives insights to past and current immunotherapies, including metabolic reprogramming, immune blockade therapy and immune modulation.This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of the advances in immunotherapy in pancreatic and colon cancer, inspire them and guide their design of novel experimental projects and translational studies.Aims to incorporate diverse and novel immunotherapeutic strategies, targeting a wide array of tumor-induced immune escape mechanismsElucidates both past and current differences in immunotherapies, while also including strategies based on monoclonal antibodies' vaccine, and oncolytic virus-related immunotherapiesProvides an updated understanding of the how resistance breaks with immunotherapy in both pancreatic and colon cancer

Epigenetic Regulations in Gastrointestinal Cancers offers a comprehensive exploration of the genomic and epigenomic alterations that underpin the aggressive nature of gastrointestinal (GI) cancers. . By synthesizing the latest research and insights into the role of the tumor microenvironment and cellular signaling pathways, this book aims to elucidate the multifaceted nature of GI cancer neoplasia and propose innovative therapeutic strategies. Addressing critical challenges in GI cancer research and treatment, this book serves as a vital resource for researchers and clinicians striving to bridge the gap between basic research and clinical application. It tackles the complexities of GI cancer mechanisms by integrating knowledge from diverse fields, thereby providing a holistic understanding essential for effective therapeutic development. Through real-world case studies and expert contributions, the book highlights successful treatment regimens that leverage epigenetic insights, thereby fostering dialogue among multidisciplinary teams and promoting collaborative approaches to cancer care. Moreover, the book emphasizes the importance of staying abreast of rapid advancements in the field of cancer research. With contributions from leading experts and an accompanying online platform featuring interactive resources, readers will have access to the latest insights and developments in GI cancer research. By identifying specific epigenetic targets and innovative strategies for overcoming treatment resistance, this book aspires to enhance patient outcomes in GI cancers and contribute to the ongoing evolution of personalized medicine in oncology.Provides an in-depth analysis of the various epigenetic changeds that contribute to the aggressiveness of gastrointestinal cancersBridges the gap between fundamental research findings and their clinical implications, offering case studies and expert insights that illustrate successful therapeutic strategiesEmphasizes the importance of multidisciplinary collaboration in cancer research and treatment, presenting contributions from experts across various subfields

Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment provides a comprehensive exploration of the complex mechanisms underlying gastrointestinal (GI) cancers, including colorectal, gastric, liver, and pancreatic malignancies. The book addresses the urgent need for innovative therapeutic strategies by synthesizing current research on DNA repair, tumor genetics, and cellular signaling pathways critical to cancer progression and treatment. It examines the roles of DNA repair mechanisms and the influence of genetic factors on personalized medicine while also discussing the potential of combining targeted therapies to enhance treatment efficacy. Featuring real-world case studies and insights from leading experts, the book bridges the gap between basic research and clinical application. For an academic audience, this resource promotes a holistic understanding of GI cancer biology, addresses treatment resistance, and fosters collaboration among researchers and clinicians, ultimately improving patient outcomes in this rapidly evolving field.Provides a thorough examination of the complex mechanisms underlying gastrointestinal cancers, including DNA repair pathways, tumor genetics, and cellular signalingBridges the gap between basic research findings and their clinical applications, featuring real-world case studies and expert insightsHighlights novel therapeutic approaches, including combination therapies and personalized medicineAddresses treatment resistance and promotes collaborative strategies

Artificial Intelligence in Gastrointestinal Cancers examines the transformative impact of AI technologies on diagnosing and treating gastrointestinal malignancies. This book explores how advanced algorithms, particularly deep learning models, enhance the analysis of medical imaging, including endoscopic, MRI, and CT scans, facilitating earlier and more accurate identification of cancers such as esophageal, stomach, colorectal, and pancreatic cancers. The content covers AI's multifaceted applications, from improving diagnostic accuracy to personalizing treatment strategies based on genomic and clinical data. It discusses how machine learning predicts patient outcomes and optimizes treatment plans while also addressing AI's role in accelerating drug discovery and clinical trials. For an academic audience, this book provides crucial insights into AI's current and future applications in GI oncology. Readers gain a comprehensive understanding of AI diagnostic tools and personalized treatment strategies, equipping researchers and clinicians with the knowledge to leverage these advancements for improved patient care and outcomes in gastrointestinal cancers.Provides a comprehensive overview of how AI algorithms are applied in the early detection and diagnosis of gastrointestinal cancersHighlights the role of machine learning in analyzing large datasets to predict treatment responses and patient outcomesOutlines how AI accelerates the process of drug discovery and optimizes clinical trial design

The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells.

Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment.

Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment.

Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment.

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy.Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents.Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents.Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers.

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers.

This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery.