Drug Development and Pharmaceutical Science – serie

Vaccine development is a complex and time consuming process that differs from the development of conventional pharmaceuticals. Primarily, vaccines are intended for use in healthy individuals as a preventative measure, requiring a long and rigorous process of research and many years of testing and development prior to clinical trials and regulatory approval. The average time for the development of vaccines to clinical is 12 to 15 years. Vaccine Development: From Concept to Clinic is a detailed overview of the development of new vaccines, covering the entire process and addresses all classes of vaccines from a processing, development and regulatory viewpoint. Utilising successful case studies the book will provide insight to the issues scientists face when producing a vaccine, the steps involved and will serve as an ideal reference tool regarding state-of-the-art vaccine development. This book is an ideal companion for any researchers working in vaccine discovery and development or with an interest in the field.

Targeted radiopharmaceutical therapy (RPT) is emerging as an innovative approach for treating a wide range of cancers.Almost all radionuclides used in RPT emit photons that can be imaged, enabling non-invasive visualization of the therapeutic agent's biodistribution. The remarkable potential of radiopharmaceutical therapy is now being recognized with recent FDA approval of several RPT drugs and a significant number of drug candidates in clinical development.This book offers a comprehensive perspective on the different technologies and addresses the critical challenges in developing and commercializing radiopharmaceuticals. It covers various topics, from clinical applications to specific radiopharmaceutical biodistribution, dosimetry, and novel targets in oncology. The chapters provide a cohesive picture of the advances in SPECT/CT and PET/CT imaging, clinical trends in targeted therapies utilizing radioisotopes for cancer imaging, and clinical applications of radiotracers within oncology areas. It also delves into the manufacturing technologies and regulatory and supply logistics required to support the development of the next wave of targeted alpha therapies.This resource is ideal for postgraduates and researchers in drug discovery and development in radionuclide therapy and imaging in cancer, as well as medical professionals engaged in nuclear medicine and radiology.

Despite remarkable advances in synthetic pharmaceuticals, natural products remain an invaluable yet underutilized resource of bioactive compounds with therapeutic potential.Rapid innovations in cultivation techniques, separation science, spectroscopic characterization, and elucidation of biosynthesis offer new promise for overcoming historic challenges in natural product research.This book makes a compelling case for researchers to continue investment in bioprospecting efforts. Through fascinating case studies, it demonstrates how emerging technologies can be used to tap into nature’s molecular diversity to meet pressing medical needs.Both students and researchers will find inspiration in this comprehensive guide to realizing the full pharmaceutical promise of natural products.

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety, and stability of the final medicinal product. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field.Following on from Pharmaceutical Formulation, which covered traditional dosage forms such as tablets and capsules, this volume expands upon those formulations to cover a more diverse range of less common dosage forms. Novel routes of administration are covered from inhalational, dermal and transdermal formulations to ocular, oral suspensions, vaccines and nanoparticle drug delivery. The methods through which these formulations are processed and manufactured is also covered, providing essential knowledge to ensure quality, efficiency, and acceptable costing. Specialised Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry and will equip readers with the ability to effectively and reliably produce products which can be approved, manufactured and made available to administer to patients.

Implantable technologies allow for a sustained control over the release of pharmaceuticals into the bloodstream thereby achieving a controlled concentration with the potential to minimise side-effects while increasing patient compliance. Significant progress has been made in various alternative implantable delivery technologies, notably in intraocular and subcutaneous devices. Despite success in research and clinical studies, long-term clinical efficacy may be more limited and different aspects related to drug development and commercialization using these technologies are not well understood or practiced in the commercial setting. This book provides a comprehensive and cohesive picture of the latest in the field while also outlining the opportunities and challenges in implantable technology. Implantable Technologies: Pepties and Biologic Drug Development is an ideal reference for any postgraduate or researcher interested in utilising implantable technologies and novel routes of drug administration. The book will also be of interest to those involved in formulation and clinical application for a wide array of disease areas in addition to more established paradigms such as diabetes and pain management.

Pharmaceutical Processing: The Science and Technology of Dosage Forms is an essential source of information on how formulations of pharmaceutical dosage forms are processed into products. Additionally, the book provides a review of related technologies and techniques used in dosage form manufacture, taking into account recent changes in regulatory and quality demands. This book is an ideal companion to pharmaceutical scientists and technologists, particularly in manufacturing and research and development, as well as trainees and new graduates interested in formulation technologies and processes. Whether in academia or industry, in a large- or small-scale company, this volume provides a wealth of detail and guidance.