This book presents peer-reviewed contributions from the 20th jubilee MICCAI 2025 Computational Biomechanics for Medicine Workshop CBM XX. The content focuses on computer-integrated medicine, which includes medical image computing and analysis, computational modelling and evaluation of surgical procedures, and imaging, analysis methods for image guided therapies, intricacies of image-guided surgery in resource-limited settings, inclusive and fair machine learning for medical imaging, computational physiology, and medical robotics.This book details the state-of-the-art and progress in above mentioned scientific fields for researchers, students, and professionals.