Glycoimmunology in Xenotransplantation

AvCheorl-Ho Kim

Häftad, Engelska, 2025

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Beskrivning

Modification or deletion of the specific gene locus for immune rejection on genome of donor animalsdisrupts the immunological recognition ligands of the donor organs, consequently preventing the immune rejection of the human recipient and xenograft rejection.

Produktinformation

Utgivningsdatum:2025-02-22
Mått:155 x 235 x 21 mm
Vikt:587 g
Format:Häftad
Språk:Engelska
Antal sidor:365
Förlag:Springer Verlag, Singapore
ISBN:9789819976935

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik

Mer om författaren

Prof. Cheorl-Ho KimMolecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University

Innehållsförteckning

Preface.- Table of Contents.- Keywords.- Chapter 1 Origin of Life and Diversity of Glycan.- Chapter 2 Current State of Xenotransplantation.- Chapter 3 Pig as Best Source for Clinical Xenotransplantation.- Chapter 4 Glycan Antigens of Pig Interfering with Xenotransplantation: Three Immune Responses from the Glycans.- Chapter 5 Glycosylation in Eukaryotes.- Chapter 6 Human Red Blood Cell (RBC) Blood Groups System.- Chapter 7 Non-ABO Blood Group Systems.- Chapter 8 Conceptual Aspect of Xenotransplantation from ABO Blood Type-incompatible Organ Allotransplantation.- Chapter 9 Classification of Rejection in Host Recipients in Xenotransplantation.- Chapter 10 Hyper Acute Rejection (HAR).- Chapter 11 Non-α1,3Gal Carbohydrate Antigenic Epitopes.- Chapter 12. Other non-a1,3Gal Antigens.- Chapter 13 Blood Mediated Inflammatory Reaction (IBMIR) and Prevention of IBMIR.- Chapter 14 Protection of Cellular Antigens from Xenoreactive Responses as Overcoming Strategies.- Chapter 15 Delayed Rejection of Xenograft (DRX).- Chapter 16 Blood Coagulation as Coagulation Dysregulation.- Chapter 17 Xenogeneic and Allogenic Cellular Rejection (CR).- Chapter 18 Induction of Xenograft Tolerance and Chimerism as an Alternative Prevention of Xenograft Rejection.- Chapter 19 Genome Editing and Transgenes in Pigs.- Chapter 20 Solid Xenoorgan Xenotransplantation.- Chapter 21 Infectious Risk and Protection.- Chapter 22 Concept of Chimeric Organisms such as Human-non-human chimera (HNH-chimera).- Chapter 23 Intra-bone Bone Marrow Transplantation.- Chapter 24 The Future of Pig Organ and Cell Xenotransplantation.- Chapter 25 Conclusions.