GM3 Signaling

Prof. Cheorl-Ho KimMolecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University

• 1. History of sialic acids, gangliosides and GM3.- 2. Synthesis of GM3.- 3. Molecular localization of GM3 in cells.- 4. Basic function of GM3 as an interacting molecule.- 5. GD3 mimetics with a neurite forming capacity.- 6. GM3 as a pathogenic infection receptor.- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis.- 8. GM3 has an anti-tumor capacity.- 9. GM3 suppresses tumor angiogenesis.- 10. Interaction between EGFR and GM3.- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling.- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase.- 13. VEGFR-GM3 interaction in angiogenesis.- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis.- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation.- 16. Galectin-1 promotes tumor growth and escapes immune surveillance.- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing.- 18. GM3, caveolin-1 and insulin receptor in insulin resistance.- 19. GM3 suppresses arthritis.- 20. GM3 protects cochlear hair cells and hearing from corti degeneration.- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1.- 22. GM3 in leukemic cells into terminal differentiation.- 23. α2,3-Sialyllactose (3SL) or α2,6-sialyllactose (6SL) of GM3 glycan in innate immunity.