Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological and Neuroimaging Parallels

The title “Sepsis-Associated Encephalopathy: Clinical, Metabolomic, Neurophysiological, and Neuroimaging Parallels” represents a knowledge-based book that includes questions of modern conception about the pathogenesis of sepsis-associated encephalopathy, pathophysiological and pathomorphological aspects of sepsis-associated encephalopathy, clinical and neurophysiological assessment of acute cerebral damage in sepsis, neuroradiological patterns of cerebral injury in sepsis, features of laboratory diagnostics based on biomarker verification and the assessment of the role of microbiota and microbial metabolites in sepsis-associated encephalopathy. Peculiarities of neurological and radiological diagnosis, the role of neurophysiological monitoring in the early detection of sepsis-associated brain dysfunction, and present and prospects in therapeutic tactics in sepsis-associated encephalopathy are the important topics of the discussion. A special chapter is devoted to the features of sepsis-associated encephalopathy in children. Finally, a very interesting chapter regarding molecular genetic aspects of diagnosis and clinical approaches to sepsis-associated encephalopathy completes the book. This book was written by anesthesiologists and intensive care, functional diagnostics specialists, neurologists, neuroradiologists, neurosurgeons, pathologists, laboratory diagnosticians, and microbiologists – 23 authors from the most reputable medical research centers and university clinics of Russia, whose daily work is to manage and treat patients of various profiles with infection and sepsis.