Eberhard Scherer – författare

Die vierte, völlig überarbeitete Auflage dieses Standardwerkes berücksichtigt neue strahlenbiologische Erkenntnisse und neue Einsatzgebiete für die Strahlentherapie. Alle Kapitel wurden entsprechend dem aktuellen interdisziplinären Stand der Onkologie überarbeitet. Zahlreiche Autoren wurden für diese Auflage hinzugewonnen. Durch die Einbeziehung neuer Gesichtspunkte zur zeitlichen Dosisverteilung, der intraoperativen Strahlentherapie, der Strahlentherapie mit schweren Teilchen, der Thermoradiotherapie und der Brachytherapie wird auch die vierte Auflage ein unentbehrliches, verläßliches Nachschlagewerk für den Radioonkologen.

Die vierte, völlig überarbeitete Auflage dieses Standardwerkes berücksichtigt neue strahlenbiologische Erkenntnisse und neue Einsatzgebiete für die Strahlentherapie. Alle Kapitel wurden entsprechend dem aktuellen interdisziplinären Stand der Onkologie überarbeitet. Zahlreiche Autoren wurden für diese Auflage hinzugewonnen. Durch die Einbeziehung neuer Gesichtspunkte zur zeitlichen Dosisverteilung, der intraoperativen Strahlentherapie, der Strahlentherapie mit schweren Teilchen, der Thermoradiotherapie und der Brachytherapie wird auch die vierte Auflage ein unentbehrliches, verläßliches Nachschlagewerk für den Radioonkologen.

The biologic effects of radiation on normal tissues and tumors represent a complex area for investigation. These effects are of far-reaching consequence to the diagnostic radiologist and the radiation oncologist having a significant impact not only in concepts relative to radiation protection but also in concepts relative to tumor biology and its response to radiation injury. The volume edited by SCHERER, STREFFER, and TROTT represents an extension of basic radiation biology data into the effects of radiation in producing pathology in organs and tissues. The data presented by the multiple authors involved in this text cover essentially all tissues in the body with specific definition of radiopathology changes and their impact on clinical care of the patient. This volume represents an important and significant contribution toward a better understanding of these effects and the pathology produced by radiations. L. W. BRADY H.-P. HEILMANN F. HEUCK M. W. DONNER Philadelphia Hamburg Stuttgart Baltimore Preface This book represents an attempt to describe the clinical radiobiology of complications arising in different organs after radiotherapy of cancer patients. Since by their very nature malignant tumors infiltrate the organ in which they have arisen and the neighboring tissues, curative radiotherapy requires the planned irradiation of considerable amounts of healthy but potentially or microscopically involved normal tissues and organs with the full target dose. This may lead to early or late normal tissue radiation injury.

The aim of radiation protection standards is to make the radiation workplace as safe as is humanly possible. The gradual evolution over the last 20 years has been towards a more precise definition of the limits for occupational exposure. These have been created not only in terms of short-term effects but also more importantly in terms of long-term risks involving such problems as the potential for carcinogenesis and genetic change. In the United States the National Committee for Radiation Protection has recom­ mended that 5 rems (50 mSv) should remain as the maximum permissible dose equiva­ lent for total body exposure. This would represent the sum of internal and external ex­ posure and should be regarded as the upper limit allowed. The community of radiation users is required to conduct its operations in such a man­ ner that the absolute value of the individual''s dose equivalent in rems does not exceed his age in years. There should be additional limits for tissues and organs based on short­ term effects. Therefore, individual organs are limited to dose equivalents low enough to ensure that the dose threshold values are not exceeded.

The aim of radiation protection standards is to make the radiation workplace as safe as is humanly possible. The gradual evolution over the last 20 years has been towards a more precise definition of the limits for occupational exposure. These have been created not only in terms of short-term effects but also more importantly in terms of long-term risks involving such problems as the potential for carcinogenesis and genetic change. In the United States the National Committee for Radiation Protection has recom­ mended that 5 rems (50 mSv) should remain as the maximum permissible dose equiva­ lent for total body exposure. This would represent the sum of internal and external ex­ posure and should be regarded as the upper limit allowed. The community of radiation users is required to conduct its operations in such a man­ ner that the absolute value of the individual's dose equivalent in rems does not exceed his age in years. There should be additional limits for tissues and organs based on short­ term effects. Therefore, individual organs are limited to dose equivalents low enough to ensure that the dose threshold values are not exceeded.