Christian Streffer - Böcker

This book offers an authoritative analysis of the state-of-the art in energy and climate research and policy.

This book offers an authoritative analysis of the state-of-the art in energy and climate research and policy.

Die menschliche Entwicklung ist seit jeher von einer gesicherten Energieversorgung abhängig, die heute aus Gründen der Machbarkeit und der Umweltbelastungen global betrachtet werden muss. Angesichts eines weltweit steigenden Energiebedarfs kommt der sicheren und preiswerten Bereitstellung von Energie daher eine Schlüsselrolle in der menschlichen Entwicklung zu. Auf der Basis der heutigen und zukünftig möglichen Energietechnologien sowie der Kenntnisse der zur Verfügung stehenden Ressourcen erarbeitet die Studie Beurteilungen der weltweiten Energieversorgung unter Einbeziehung wirtschaftlicher und umweltverträglicher Kriterien. Es werden ferner Aspekte der Langfristigkeit, der Sozialverträglichkeit und der Verteilungsgerechtigkeit in den Diskurs einbezogen.

The setting of limit values for environmental noxae is essentially based on measurements and data from single exposures. To an increasing degree, however, there are demands also to consider combined exposures. Hence, in this study, the necessity and feasability of environmental standards for combined exposures have been examined from the scientific, medical, economic, legal, sociological and philosophical/ethical perspective. Starting from effect mechanisms, criteria have been established which, in spite of the complexity of the issues, enable us to set limit values in order to achieve given environmental quality targets. This study endeavours to reveal and explain gaps in knowledge and to point to possible solutions from the scientific and medical point of view. The results should support efforts to shape a practical legal framework and viable economic procedures for environmental standards on combined exposures, taking into consideration the standards and perceptions existing in our communities.

The setting of limit values for environmental noxae is essentially based on measurements and data from single exposures. To an increasing degree, however, there are demands also to consider combined exposures. Hence, in this study, the necessity and feasability of environmental standards for combined exposures have been examined from the scientific, medical, economic, legal, sociological and philosophical/ethical perspective. Starting from effect mechanisms, criteria have been established which, in spite of the complexity of the issues, enable us to set limit values in order to achieve given environmental quality targets. This study endeavours to reveal and explain gaps in knowledge and to point to possible solutions from the scientific and medical point of view. The results should support efforts to shape a practical legal framework and viable economic procedures for environmental standards on combined exposures, taking into consideration the standards and perceptions existing in our communities.

Radioactive waste (above all highly radioactive wastes from nuclear installations) caused by research, medicine and technology must be disposed of safely. However both the strategies disputed for the disposal of radioactive waste as well as concrete proposals for choosing a location for final waste disposal are highly debatable. An appropriate disposal must conform to both complex, technical requirements and fulfill the radio-biological conditions to appropriately protect man and nature. Ethical, legal and social conditions must also be considered. An interdisciplinary team from various, relevant fields compiled the current status-quo and developed criteria and strategies, which on the one hand meet the requirements of optimal warning and prevention of risk for present and future generations, and additionally on the other hand meet the needs of what current society agrees what is expected to be allowed. This study can be understood as an advanced and continuing contribution to the corresponding scientific specialized debates, due to its interdisciplinary treatment. At the same time it serves as a fundamentally informing contribution to public and political debates, offering an easily comprehensible executive summary and precise content recommendations.

Radioactive waste (above all highly radioactive wastes from nuclear installations) caused by research, medicine and technology must be disposed of safely. However both the strategies disputed for the disposal of radioactive waste as well as concrete proposals for choosing a location for final waste disposal are highly debatable. An appropriate disposal must conform to both complex, technical requirements and fulfill the radio-biological conditions to appropriately protect man and nature. Ethical, legal and social conditions must also be considered. An interdisciplinary team from various, relevant fields compiled the current status-quo and developed criteria and strategies, which on the one hand meet the requirements of optimal warning and prevention of risk for present and future generations, and additionally on the other hand meet the needs of what current society agrees what is expected to be allowed. This study can be understood as an advanced and continuing contribution to the corresponding scientific specialized debates, due to its interdisciplinary treatment. At the same time it serves as a fundamentally informing contribution to public and political debates, offering an easily comprehensible executive summary and precise content recommendations.

Tumour therapy depends essentially on being able to destroy the clonogenic activity of tumour cells while keeping the damage to the normal tissue low. Clinical experience shows that tumour response varies greatly even if tumours with the same localisation, clinical, and histopathological staging are compared. Some tumours appear to be resistant to conventional radiotherapy (X-rays, y-rays or fast electrons) or chemotherapy. In these cases new therapy modalities are necessary. Combined therapy modalities seem to have advan- tages for some resistant tumours; one possibility of such a treatment is to combine radiotherapy or chemotherapy with hyperthermia. This means that the local tumour, the tumour region or even the whole body of the patient has to be heated to temperatures between 40 to 45 C (in case of whole body hyperthermia to 42 C maximal) for a certain time (usually 30-60 min are adequate). Hyperthermia has a long tradition in medicine as a treatment modality for various diseases. Inscriptions of the old Egyptians and texts of the Greeks have pointed out its importance. Usually whole body hyperthermia has been used by the induction of fever.Local hyperthermia began around 1900 when Westermark treated unre- sectable cervix carcinomas with hot water in a metallic coil. By the beginning of this century an increase of radiation effects was hy- pothesised with hypothermia and later observed. However, only in the 1960s and 1970s were systematic investigations started which showed radiosensitisation and chemosensitisation by hyperthermia in cells and tissues including tumours.

The biologic effects of radiation on normal tissues and tumors represent a complex area for investigation. These effects are of far-reaching consequence to the diagnostic radiologist and the radiation oncologist having a significant impact not only in concepts relative to radiation protection but also in concepts relative to tumor biology and its response to radiation injury. The volume edited by SCHERER, STREFFER, and TROTT represents an extension of basic radiation biology data into the effects of radiation in producing pathology in organs and tissues. The data presented by the multiple authors involved in this text cover essentially all tissues in the body with specific definition of radiopathology changes and their impact on clinical care of the patient. This volume represents an important and significant contribution toward a better understanding of these effects and the pathology produced by radiations. L. W. BRADY H.-P. HEILMANN F. HEUCK M. W. DONNER Philadelphia Hamburg Stuttgart Baltimore Preface This book represents an attempt to describe the clinical radiobiology of complications arising in different organs after radiotherapy of cancer patients. Since by their very nature malignant tumors infiltrate the organ in which they have arisen and the neighboring tissues, curative radiotherapy requires the planned irradiation of considerable amounts of healthy but potentially or microscopically involved normal tissues and organs with the full target dose. This may lead to early or late normal tissue radiation injury.