Huzefa Rangwala - Böcker

A look at the methods and algorithms used to predict protein structureA thorough knowledge of the function and structure of proteins is critical for the advancement of biology and the life sciences as well as the development of better drugs, higher-yield crops, and even synthetic bio-fuels. To that end, this reference sheds light on the methods used for protein structure prediction and reveals the key applications of modeled structures. This indispensable book covers the applications of modeled protein structures and unravels the relationship between pure sequence information and three-dimensional structure, which continues to be one of the greatest challenges in molecular biology.With this resource, readers will find an all-encompassing examination of the problems, methods, tools, servers, databases, and applications of protein structure prediction and they will acquire unique insight into the future applications of the modeled protein structures. The book begins with a thorough introduction to the protein structure prediction problem and is divided into four themes: a background on structure prediction, the prediction of structural elements, tertiary structure prediction, and functional insights. Within those four sections, the following topics are covered: Databases and resources that are commonly used for protein structure predictionThe structure prediction flagship assessment (CASP) and the protein structure initiative (PSI)Definitions of recurring substructures and the computational approaches used for solving sequence problemsDifficulties with contact map prediction and how sophisticated machine learning methods can solve those problemsStructure prediction methods that rely on homology modeling, threading, and fragment assemblyHybrid methods that achieve high-resolution protein structuresParts of the protein structure that may be conserved and used to interact with other biomoleculesHow the loop prediction problem can be used for refinement of the modeled structuresThe computational model that detects the differences between protein structure and its modeled mutantWhether working in the field of bioinformatics or molecular biology research or taking courses in protein modeling, readers will find the content in this book invaluable.

Learning Analytics in Higher Education provides a foundational understanding of how learning analytics is defined, what barriers and opportunities exist, and how it can be used to improve practice, including strategic planning, course development, teaching pedagogy, and student assessment. Well-known contributors provide empirical, theoretical, and practical perspectives on the current use and future potential of learning analytics for student learning and data-driven decision-making, ways to effectively evaluate and research learning analytics, integration of learning analytics into practice, organizational barriers and opportunities for harnessing Big Data to create and support use of these tools, and ethical considerations related to privacy and consent. Designed to give readers a practical and theoretical foundation in learning analytics and how data can support student success in higher education, this book is a valuable resource for scholars and administrators.

Learning Analytics in Higher Education provides a foundational understanding of how learning analytics is defined, what barriers and opportunities exist, and how it can be used to improve practice, including strategic planning, course development, teaching pedagogy, and student assessment. Well-known contributors provide empirical, theoretical, and practical perspectives on the current use and future potential of learning analytics for student learning and data-driven decision-making, ways to effectively evaluate and research learning analytics, integration of learning analytics into practice, organizational barriers and opportunities for harnessing Big Data to create and support use of these tools, and ethical considerations related to privacy and consent. Designed to give readers a practical and theoretical foundation in learning analytics and how data can support student success in higher education, this book is a valuable resource for scholars and administrators.

This SpringerBrief covers the technical material related to large scale hierarchical classification (LSHC). HC is an important machine learning problem that has been researched and explored extensively in the past few years. In this book, the authors provide a comprehensive overview of various state-of-the-art existing methods and algorithms that were developed to solve the HC problem in large scale domains. Several challenges faced by LSHC is discussed in detail such as: 1. High imbalance between classes at different levels of the hierarchy2. Incorporating relationships during model learning leads to optimization issues 3. Feature selection 4. Scalability due to large number of examples, features and classes 5. Hierarchical inconsistencies 6. Error propagation due to multiple decisions involved in making predictions for top-down methodsThe brief also demonstrates how multiple hierarchies can be leveraged forimproving the HC performance using different Multi-Task Learning (MTL) frameworks.The purpose of this book is two-fold:1. Help novice researchers/beginners to get up to speed by providing a comprehensive overview of several existing techniques. 2. Provide several research directions that have not yet been explored extensively to advance the research boundaries in HC.New approaches discussed in this book include detailed information corresponding to the hierarchical inconsistencies, multi-task learning and feature selection for HC. Its results are highly competitive with the state-of-the-art approaches in the literature.