J.F. Goodwin – författare
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550 kr
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The international symposium organized by the Italian Study Group on Cardiomyopathies (SPIC) and planned by the organiz- ing and scientific committees opened with a review of the history of cardiomyopathy over the last 30 years by Goodwin, London (UK) and continued with presentations on all aspects of hyper- trophic and dilated cardiomyopathy by a wide spectrum of inter- national experts. This book includes mainly the invited contributions, but there are also many original oral presentations. Hypertrophic cardiomyopathy is well addressed by papers on natural history, ventricular function, ischaemia and arrhythmia. Of particular interest is the note by Bonow, National Heart Lung and Blood Institute (NHLBI; USA), on the effect of beta-adrenergic stimulation with isoprenalin in increasing the rate and extent of left ventricular relaxation, beta-adrenergic blocking agents having no such effect. In contrast, verapamil improves ventricular relaxation as would be expected.These results challenge accepted belief in some ways and indicate that multiple factors - both passive and active - acting on the left ventricle, such as ischaemia, asynchrony, altered left ventricu- lar loading and intracellular levels of calcium ions, are all oper- ating. These aspects are the more interesting in view of the recent reports of an increase in calcium-channel receptors, but not in beta-adrenergic receptors, in hypertrophic cardiomyo- pathy.
550 kr
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Twenty five years ago, cardiomyopathies or myocardopathies as they were sometimes called, were in very small print, and often the terms myocarditis and cardiomyopathy were used interchangeably. Now definition and classifi cation can be precise and terminology has been refined. Although a great deal still has to be learnt about the heart muscle diseases, they have now achieved the status of an important group of cardiovascular disorders. Their importance is out of proportion to their frequency because the cardiomyopathies so often attack young otherwise active and healthy people, and are notable for sudden unexpected death, and for intractable congestive heart failure. They are especially a meance in age groups younger than those most commonly effected by coronary heart disease. This book presents an analysis and review by many experts of the present knowledge about heart muscle diseases and employs the approach to classi fication and terminology now generally, though not universally, agreed. It will be apparent that much fundamental research must be done now that the clinical problems have been defined. In the future, the collaboration of molecular biologists and other basic scientists will be needed to illuminate the dark places of our ignorance.