Kenneth Douglas – författare

Of the 121,000 people on donor lists in the U.S., over 100,000 need kidney transplants and thousands die each year while waiting. Bioprinting aspires to build healthy kidney tissue from a patient's own cells and transplant this to boost failing kidneys without fear of rejection...As the 21st century dawned, a handful of inspired scientists tried to use 3D printing to create living human tissue. Their vision was to restore the health of people with intractable injuries, such as worn out cartilage, severed nerves, ailing kidneys, failing hearts—the gamut of human frailties. Their modest success energized others to join the quest. Now, after two decades of ingenious effort and hard work, they have carved out a vibrant new discipline: bioprinting.In Bioprinting: To Make Ourselves Anew, physicist Kenneth Douglas casts an eye over the achievements and future of bioprinting. He explains the science with rigor but with a minimum of technical baggage. This is the first book on the subject written expressly for the lay audience: accessible and even entertaining. Douglas interviewed two dozen bioprinting researchers from around the world, and he enriches the narrative by sharing stories from the scientists behind the science. These contemporary vignettes are complemented by historical accounts of the women and men whose prescient contributions were foundational to the development of bioprinting.The book describes the challenges and accomplishments in the bioprinting of blood vessels, cartilage, skin, bone, skeletal muscle, neuromuscular junctions, liver, heart, lung, kidney, and so-called organs-on-a-chip, as well as the challenges of providing a blood supply and nerves to bioprinted tissues. This is a compelling tale of a work in progress: to imitate nature and help heal people with debilitating afflictions.

Of the 121,000 people on donor lists in the U.S., over 100,000 need kidney transplants and thousands die each year while waiting. Bioprinting aspires to build healthy kidney tissue from a patient''s own cells and transplant this to boost failing kidneys without fear of rejection...As the 21st century dawned, a handful of inspired scientists tried to use 3D printing to create living human tissue. Their vision was to restore the health of people with intractable injuries, such as worn out cartilage, severed nerves, ailing kidneys, failing heartsthe gamut of human frailties. Their modest success energized others to join the quest. Now, after two decades of ingenious effort and hard work, they have carved out a vibrant new discipline: bioprinting.In Bioprinting: To Make Ourselves Anew, physicist Kenneth Douglas casts an eye over the achievements and future of bioprinting. He explains the science with rigor but with a minimum of technical baggage. This is the first book on the subject written expressly for the lay audience: accessible and even entertaining. Douglas interviewed two dozen bioprinting researchers from around the world, and he enriches the narrative by sharing stories from the scientists behind the science. These contemporary vignettes are complemented by historical accounts of the women and men whose prescient contributions were foundational to the development of bioprinting.The book describes the challenges and accomplishments in the bioprinting of blood vessels, cartilage, skin, bone, skeletal muscle, neuromuscular junctions, liver, heart, lung, kidney, and so-called organs-on-a-chip, as well as the challenges of providing a blood supply and nerves to bioprinted tissues. This is a compelling tale of a work in progress: to imitate nature and help heal people with debilitating afflictions.

Of the 121,000 people on donor lists in the U.S., over 100,000 need kidney transplants and thousands die each year while waiting. Bioprinting aspires to build healthy kidney tissue from a patient''s own cells and transplant this to boost failing kidneys without fear of rejection...As the 21st century dawned, a handful of inspired scientists tried to use 3D printing to create living human tissue. Their vision was to restore the health of people with intractable injuries, such as worn out cartilage, severed nerves, ailing kidneys, failing heartsthe gamut of human frailties. Their modest success energized others to join the quest. Now, after two decades of ingenious effort and hard work, they have carved out a vibrant new discipline: bioprinting.In Bioprinting: To Make Ourselves Anew, physicist Kenneth Douglas casts an eye over the achievements and future of bioprinting. He explains the science with rigor but with a minimum of technical baggage. This is the first book on the subject written expressly for the lay audience: accessible and even entertaining. Douglas interviewed two dozen bioprinting researchers from around the world, and he enriches the narrative by sharing stories from the scientists behind the science. These contemporary vignettes are complemented by historical accounts of the women and men whose prescient contributions were foundational to the development of bioprinting.The book describes the challenges and accomplishments in the bioprinting of blood vessels, cartilage, skin, bone, skeletal muscle, neuromuscular junctions, liver, heart, lung, kidney, and so-called organs-on-a-chip, as well as the challenges of providing a blood supply and nerves to bioprinted tissues. This is a compelling tale of a work in progress: to imitate nature and help heal people with debilitating afflictions.

What are the neural circuits that underpin behavior, both in psychiatric illness and in health? Can we understand what is going on in the brain of a person suffering depression, or who has an anxiety disorder, or is addicted to drugs? And what of our fundamental functions and survival drives: what are the connections between neurons that enable us to form, store, and retrieve memories, to feel empathy, to act as parents to our children? In the early years of the twenty-first century, a new technology in neuroscience has emerged to unveil the causal relationship between the activity of specific neurons and the behaviors they control. That technology is called optogenetics. Optogenetics is a combination of optics and genetics to control well-defined events within specific cells of living tissue, the better to understand the mechanistic origins of those events. The technique includes the insertion into cells of genes that bestow light responsiveness to the proteins they produce, the means for delivering light deep into living, freely moving mammals, the targeting of light-sensitivity only to cells of interest, and ways for evaluating the effects of this optical control on behavior.Optogenetics enables scientists to both “read” and “write” the neural code. Optogenetics empowers the control of well-defined events in neurons in real time by employing genes that confer light responsiveness. Most importantly, it is a transformational step toward causal neuroscience. Moving beyond a history of mostly observation and correlation, optogenetics now provides neuroscientists with the ability to switch neural function on and off with cell-specificity and millisecond accuracy. Because of conserved brain structure among species, optogenetic study of animal models has yielded invaluable insights into human problems such as anxiety, depression, addiction, autism, Alzheimer's disease and Parkinson's disease. It has revealed the brain circuits responsible for parenting behavior, how memory works (and malfunctions), how percepts are formed from our visual experience, and other feats not previously possible.

Acclaimed upon its initial American release, Black Poets of the United Statescontinued to spark comment and analysis for years afterward. Jean Wagner's masterpiece delves into the vital union of racial and religious feeling in the Black poets who emerged from 1890 to 1940. Beginning with an analysis of slavery's impact on the Black psyche and religious feeling, Wagner examines the evolution of Black lyrical expression to the end of the nineteenth century. He then moves into a focused study of Paul Laurence Dunbar and his contemporaries, emphasizing their struggle against prevalent stereotypes that stemmed from minstrelsy, popular song, and southern white writing. His look at the twentieth-century Black Renaissance explores the works, themes, concerns, and experiences of poets Claude McKay, Jean Toomer, Countee Cullen, James Weldon Johnson, Sterling Brown, and Langston Hughes. Deeply sensitive and remarkably comprehensive Black Poets of the United States combines encyclopedic knowledge with a broad perspective to provide a pioneering examination of major African American poets and their works.

DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology melds two tales of DNA. One is a look at the first 35 years of DNA nanotechnology to better appreciate what lies ahead in this emerging field. The other story looks back 4 billion years to the possible origins of DNA which are shrouded in mystery. The book is divided into three parts comprised of 15 chapters and two Brief Interludes. Part I includes subjects underpinning the book such as a primer on DNA, the broader discipline of nanoscience, and experimental tools used by the principals in the narrative. Part II examines the field of structural DNA nanotechnology, founded by biochemist/crystallographer Nadrian Seeman, that uses DNA as a construction material for nanoscale structures and devices, rather than as a genetic material. Part III looks at the work of physicists Noel Clark and Tommaso Bellini who found that short DNA (nanoDNA) forms liquid crystals that act as a structural gatekeeper, orchestrating a series of self-assembly processes using nanoDNA. This led to an explanation of the polymeric structure of DNA and of how life may have emerged from the prebiotic clutter.

DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology melds two tales of DNA. One is a look at the first 35 years of DNA nanotechnology to better appreciate what lies ahead in this emerging field. The other story looks back 4 billion years to the possible origins of DNA which are shrouded in mystery. The book is divided into three parts comprised of 15 chapters and two Brief Interludes.Part I includes subjects underpinning the book such as a primer on DNA, the broader discipline of nanoscience, and experimental tools used by the principals in the narrative. Part II examines the field of structural DNA nanotechnology, founded by biochemist/crystallographer Nadrian Seeman, that uses DNA as a construction material for nanoscale structures and devices, rather than as a genetic material. Part III looks at the work of physicists Noel Clark and Tommaso Bellini who found that short DNA (nanoDNA) forms liquid crystals that act as a structural gatekeeper, orchestrating a series of self-assembly processes using nanoDNA. This led to an explanation of the polymeric structure of DNA and of how life may have emerged from the prebiotic clutter.