Lewis Wolpert – författare

Wolpert's Principles of Development, the latest edition of the prize-winning textbook, opens up the fascinating field of developmental biology to undergraduates studying biology, medicine, and veterinary science. By focusing on the underlying processes shared by diverse organisms, the textbook lays the foundation for a deep understanding. Key features - An emphasis throughout on the underlying principles - which underpin the commonalities between different organisms and their development - enables students to get a clear sense of the 'big picture' of the subject. - Custom-drawn artwork and integrated animations and videos help to make the visualisation of processes and mechanisms in this challenging subject as straightforward as possible. - Medical Boxes explore key developmental diseases and explain how developmental biology furthers our understanding human health and disease. Further experimental detail, including Experimental Boxes, from both classic and current research, demonstrates 'how we know what we know'. - Also available as an e-book enhanced with learning objectives, self-assessment interactive quizzes and multi-media content to offer a fully immersive experience and extra learning support. New to this edition - Chapter 7, a new chapter on Embryonic stem cells, embryo models, and regenerative medicine, to ensure the book's coverage stays up to date with this very active area of developmental biology research. - Chapters 3 and 4 on vertebrate development have been restructured and updated, especially in relation to mouse development, to ensure major concepts and principles are explained with recent supporting experimental evidence. - Chapter 10 on the nervous system has been completely revised and updated, with more emphasis on neural tube patterning. - Chapter 14, which covers nematodes and sea urchins, now appears online as part of the ebook. - There are more examples of the use of CRISPR to address problems like sickle cell disease (Ch6), and evolution of limbs from fins (Ch13). - Examples of single-cell RNA sequencing can be found throughout the book (Ch3, Ch6, Ch7, Ch10, Ch11, Ch12). - Smaller revisions, updates, and new figures have been included throughout. Digital formats and resources The seventh edition is available for students and institutions to purchase in a variety of formats: the e-book and Science Trove offer a mobile experience and convenient access along with interactive self-test questions, videos, flashcards, supplementary materials, functionality tools, navigation features and links that offer extra learning support. For more information about e-books, please visit www.oxfordtextbooks.co.uk/ebooks

The popular stereotype of the scientist as mad boffin or weedy nerd has been peddled widely in film and fiction, with the implication that the world of science is far removed from the intellectual and emotional messiness of other human activities. In Passionate Minds, distinguished scientist Lewis Wolpert investigates the style and motivation of some of the most eminent scientists in the world. In this stimulating collection of conversations, scientists in fields as diverse as particle physics and evolutionary biology explore how their backgrounds have shaped their careers and discoveries - how being an outsider or an "innocent" can play an invaluable role in overcoming conventional barriers to new understanding. Being a little crazy does seem to help. As Nobel laureate for physics Sheldon Glashow says, "If you would simply take all the kookiest ideas of the early 1970s and put them together you would have made for yourself the theory which is, in fact, the correct theory of nature, so it was like madness..." These personal explorations with individual scientists are not only accessible and truly fascinating in their insights into the minds of some of the greatest men and women of science, but they also provide a strong case that the life and works of our leading scientists are at least as illuminating and interesting as the personalities of the latest literary prizewinners. A sequel to A Passion for Science, this book will delight and intrigue scientists and non-scientists alike.

Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clearly a significant public health problem. As our knowledge of this illness has expanded in recent years, it has become clear that depression can no longer be viewed as a simple disorder of the brain. It has to be seen as a series of behavioural and biological changes that span mind, brain, genes, and body - indeed affecting both psychological and physical health. This book brings together world leaders in research on depression, to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psychological, genetic and evolutionary models, with a particular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore linking depression to physical health. Opening with a powerful, personal, account of depression, that conveys something of the all-consuming, debilitating, nature of this illness, the book then presents cutting edge research from those at the frontiers of work in this area. The book will be valuable for all psychiatrists, clinical psychologists and neuroscientists seeking a state-of-the-art of this global problem

From a single cell - a fertilized egg - comes an elephant, a fly, or a human. How does this astonishing feat happen? How does the egg 'know' what to become? How does it divide into the different cells, the separate tissues, the brain, the fingernail - every tiniest detail of the growing foetus?These are the questions that the field of developmental biology seeks to answer. It is an area that is closely linked to genetics, evolution, and molecular biology. The processes are deeply rooted in evolutionary history; the information is held in genes whose vital timings in switching on and off is orchestrated by a host of proteins expressed by other genes. Timing is of the essence. Here, the distinguished developmental biologist Lewis Wolpert gives a concise account of what we now know about development, discussing the first vital steps of growth, the patterning created by Hox genes and the development of form, embryonic stem cells, the timing of gene expression and its management, chemical signalling, and growth.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

"Marvelously funny and provocative."-Publishers Weekly

In the tradition of the classic "Lives of a Cell," but with the benefit of the latest research, an internationally acclaimed embryologist demonstrates how human life derives from a single cell and then grows into a body, an incredibly complex society made up of billions of them.

'An excellent book, the most objective short account I know of all the various approaches to depression.' Anthony Storr Several years ago, Lewis Wolpert had a severe episode of depression. Despite a happy marriage and successful scientific career, he could think only of suicide. When he did recover, he became aware of the stigma attached to depression - and just how difficult it was to get reliable information. With characteristic candour and determination he set about writing this book, an acclaimed investigation into the causes and treatments of depression, which formed the basis for a BBC TV series.This paperback edition features a new introduction, in which Wolpert discusses the reaction to his book and BBC series, and recounts his own recurring struggle with depression.

Why does every society around the world have a religious tradition of some sort? Professor Lewis Wolpert investigates the nature of belief and its causes. He looks at belief's psychological basis and its possible evolutionary origins in physical cause and effect. Wolpert explores the different types of belief - including that of animals, of children, of the religious, and of those suffering from psychiatric disorders. And he asks whether it is possible to live without belief at all, or whether it is a necessary component of a functioning society.

Cells are the basis of all life in the universe. Our bodies are made up of billions of them: an incredibly complex society that governs everything, from movement to memory and imagination. When we age, it is because our cells slow down; when we get ill, it is because our cells mutate or stop working.In How We Live and Why we Die, Wolpert provides a clear explanation of the science that underpins our lives. He explains how our bodies function and how we derived from a single cell - the embryo. He examines the science behind the topics that are much discussed but rarely understood - stem-cell research, cloning, DNA - and explains how all life evolved from just one cell. Lively and passionate, How We Live and Why we Die is an accessible guide to understanding the human body and, essentially, life itself.