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Wolpert's Principles of Development, the latest edition of the prize-winning textbook, opens up the fascinating field of developmental biology to undergraduates studying biology, medicine, and veterinary science. By focusing on the underlying processes shared by diverse organisms, the textbook lays the foundation for a deep understanding. Key features - An emphasis throughout on the underlying principles - which underpin the commonalities between different organisms and their development - enables students to get a clear sense of the 'big picture' of the subject. - Custom-drawn artwork and integrated animations and videos help to make the visualisation of processes and mechanisms in this challenging subject as straightforward as possible. - Medical Boxes explore key developmental diseases and explain how developmental biology furthers our understanding human health and disease. Further experimental detail, including Experimental Boxes, from both classic and current research, demonstrates 'how we know what we know'. - Also available as an e-book enhanced with learning objectives, self-assessment interactive quizzes and multi-media content to offer a fully immersive experience and extra learning support. New to this edition - Chapter 7, a new chapter on Embryonic stem cells, embryo models, and regenerative medicine, to ensure the book's coverage stays up to date with this very active area of developmental biology research. - Chapters 3 and 4 on vertebrate development have been restructured and updated, especially in relation to mouse development, to ensure major concepts and principles are explained with recent supporting experimental evidence. - Chapter 10 on the nervous system has been completely revised and updated, with more emphasis on neural tube patterning. - Chapter 14, which covers nematodes and sea urchins, now appears online as part of the ebook. - There are more examples of the use of CRISPR to address problems like sickle cell disease (Ch6), and evolution of limbs from fins (Ch13). - Examples of single-cell RNA sequencing can be found throughout the book (Ch3, Ch6, Ch7, Ch10, Ch11, Ch12). - Smaller revisions, updates, and new figures have been included throughout. Digital formats and resources The seventh edition is available for students and institutions to purchase in a variety of formats: the e-book and Science Trove offer a mobile experience and convenient access along with interactive self-test questions, videos, flashcards, supplementary materials, functionality tools, navigation features and links that offer extra learning support. For more information about e-books, please visit www.oxfordtextbooks.co.uk/ebooks

One of the most fascinating problems in biology is how a single cell, the fertilised egg, gives rise to a new individual. The fertilised egg divides many times to form an embryo. This volume in the Frontiers in Molecular Biology series discusses the methods by which cells in distinct regions of an embryo become different, a process known as patterning. Patterning is fundamental to establishing the spatial organisation of the developing embryo. It ensures that all the parts of the body are generated and that they form in exactly the right places. The ultimate in patterning is the formation of precise arrangements of specialised cells and tissues within each organ. Understanding the process of patterning during the embryonic development of vertebrates is a particular challenge for developmental biologists because vertebrates have an intricate and complex anatomy and histology. The first two chapters of Patterning in Vertebrate Development are introductory, explaining to the reader the general principles of vertebrate patterning and early embryology. The subsequent chapters address patterning in both nervous system and specific parts of the body.Each chapter provides a detailed review of current research in a specific area of interest. These include topics such as neural specification, antero-posterior patterning of the neural tube, and molecular basis of vertebrate limb development. Throughout the volume, examples are drawn from a number of species, and particular emphasis is placed on recent discoveries about the molecular basis of patterning in vertebrates. The book concludes with a chapter which revisits many of the regions of the embryo previously discussed from an evolutionary perspective.