Manfred Clynes – författare

This text is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the MDR genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a combination of approaches to this serious clinical problem. This book covers a wide range of topics relating to the cellular and molecular biology, as well as clinical aspects, of the problem of multiple drug resistance. Specific mechanisms discussed in detail include P-Glycoprotein and other drug transport proteins; Topoisomerases I and II; Phase I and Phase II enzymes of xenobiotic metabolism.Cellular models for MDR in solid tumours and in haemopoietic cells are discussed in detection of expression of MDR-related genes, and approaches to circumvent MDR.

There is much music in our lives -yet we know little about its function. Music is one of man''s most remarkable inventions - though possibly it may not be his invention at all: like his capacity for language his capacity for music may be a naturally evolved biologic .function. All cultures and societies have music. Music differs from the sounds of speech and from other sounds, but only now do we find ourselves at the threshold of being able to find out how our brain processes musical sounds differently from other sounds. We are going through an exciting time when these questions and the question of how music moves us are being seriously investigated for the first time from the perspective of the co-ordinated functioning of the organism: the perspective of brain function, motor function as well as perception and experience. There is so much we do not yet know. But the roads to that knowledge are being opened, and the coming years are likely to see much progress towards providing answers and raising new questions. These questions are different from those music theorists have asked themselves: they deal not with the structure of a musical score (although that knowledge is important and necessary) but with music in the flesh: music not outside of man to be looked at from written symbols, but music-man as a living entity or system.

There is much music in our lives -yet we know little about its function. Music is one of man's most remarkable inventions - though possibly it may not be his invention at all: like his capacity for language his capacity for music may be a naturally evolved biologic .function. All cultures and societies have music. Music differs from the sounds of speech and from other sounds, but only now do we find ourselves at the threshold of being able to find out how our brain processes musical sounds differently from other sounds. We are going through an exciting time when these questions and the question of how music moves us are being seriously investigated for the first time from the perspective of the co-ordinated functioning of the organism: the perspective of brain function, motor function as well as perception and experience. There is so much we do not yet know. But the roads to that knowledge are being opened, and the coming years are likely to see much progress towards providing answers and raising new questions. These questions are different from those music theorists have asked themselves: they deal not with the structure of a musical score (although that knowledge is important and necessary) but with music in the flesh: music not outside of man to be looked at from written symbols, but music-man as a living entity or system.

This book summarises the proceedings of a symposium on "Emotions and Psychopathology" which was held by the Department of Psychology of Bowling Green State University from September 26-27, 1986. It is coming to be realized that to understand the underlying structure and dynamics of many psychopathologies, it is essential to understand the nature of emotions. The aim of this symposium was to gather a group of investigators and thinkers who would have valuable and unique perspectives on the nature of emotions and on their relationship to psychic disorders. The main participants were Manfred Clynes, Helen Block Lewis, Michael Liebowitz, Marvin Minsky, Robert Plutchik, John Paul Scott and Jaak Panksepp. Ted Melnechuk chaired the half-day of round table discussion on the day following the symposium, and Gail Zivin and Larry Stettner presented informal position statements on ethologi­ during the round table. On the evening before the symposium, Elliot cal approaches Valenstein of The University of Michigan presented a pre-symposium colloquium entitled "Great and Desperate Cures" which summarized his most recent contribu­ tion to the Psychosurgery debate. We should like to refer you to his excellent book on the subject, with the same title, (Basic Books,1986), which can help forewarn us of possible future worries in the application of biological technologies. Paul Byers who did not attend the meeting was invited to write a chapter summarizing cultural and societal issues which were not formally covered at the meeting.