M. Clynes – författare
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2 produkter
2 produkter
Inbunden, Engelska, 1994
894 kr
Skickas inom 10-15 vardagar
This text is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the MDR genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a combination of approaches to this serious clinical problem. This book covers a wide range of topics relating to the cellular and molecular biology, as well as clinical aspects, of the problem of multiple drug resistance. Specific mechanisms discussed in detail include P-Glycoprotein and other drug transport proteins; Topoisomerases I and II; Phase I and Phase II enzymes of xenobiotic metabolism.Cellular models for MDR in solid tumours and in haemopoietic cells are discussed in detection of expression of MDR-related genes, and approaches to circumvent MDR.
Inbunden, Engelska, 1999
2 224 kr
Skickas inom 10-15 vardagar
Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.