Martin Clynes – författare
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4 produkter
4 produkter
Multiple Drug Resistance in Cancer 2
Molecular, Cellular and Clinical Aspects
Inbunden, Engelska, 1999
2 183 kr
Skickas inom 10-15 vardagar
This multi-author volume brings together a wide range of reviews on different aspects of our knowledge of drug-resistance mechanisms. Particular attention is paid to mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularization of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book should be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
1 486 kr
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Cell culture techniques allow a variety of molecular and cellular biological questions to be addressed, offering physiological conditions whilst avoiding the use of laboratory animals. In addition to basic techniques, a range of specialised practical protocols covering the following areas are included: cell proliferation and death; in-vitro models models for cell differentiation; in-vitro models for toxicology and pharmacology; industrial application of animal cell culture; and genetic manipulation and analysis of human and animal cells in culture.
2 183 kr
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Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
551 kr
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This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.