Sang Jin Lee – författare

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.

Explores the body's ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body's own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications-from the cell level to applications-in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body''s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body''s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.- Explores the body''s ability to mobilize endogenous stem cells to the site of injury- Details the latest strategies developed for inducing and supporting the body''s own regenerating capacity- Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume- Features chapter authors and editors who are authorities in this emerging field- Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing, Volume Four in the Regenerative and Transplant Medicine series, offers a range of benefits tailored to its diverse audience. For students in biomedical engineering and related fields, the book provides a comprehensive understanding of biofabrication technologies in tissue and organ engineering, preparing them for future careers. Researchers and scientists in tissue engineering will benefit from staying current with the latest advancements, fostering interdisciplinary collaboration, and offering practical insights for experimental design. Clinicians and healthcare professionals will gain a deeper understanding of biofabrication applications, thus improving patient care and staying informed about emerging technologies.Industry professionals in medical devices and biofabrication will find valuable insights for product development and market opportunities, while educators can use the textbook to enrich curricula and provide real-world applications for students. Regulatory affairs specialists will benefit from updates on ethical considerations and compliance in biofabrication, and government officials will gain insights for shaping policies.Provides the latest release in the Regenerative and Transplant Medicine seriesFocuses on biofabrication for tissue and organ engineeringPresents current progress and future prospects on biofabrication technologies for tissue and organ engineeringIncludes regulatory and ethical considerations

The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function.In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years. A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.