In Situ Tissue Regeneration

Dr. Lee has extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. His research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. Dr. Lee’s research team also demonstrated the principle of “in situ tissue regeneration” that is to take advantage of the body’s own regenerating capacity by using the host's ability to mobilize endogenous stem cells to the site of injury. Currently, his research has focused on development of strategies for in situ tissue regeneration in terms of mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system from the perspective of regenerative medicine and tissue engineering. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society. Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

• 1. Fundamentals of In Situ Tissue RegenerationSang Jin Lee, James J. Yoo and Antony Atala2. Stem Cell HomingMariusz Z. Ratajczak and Ahmed A. Ismail3. Immunology – Host Responses to BiomaterialsJohn D. Jackson4. Foreign Body Reaction and Stem Cell ResponsesAshwin Nair and Liping Tang5.  Roles of endogenous growth factors and small peptides in in situ tissue regenerationSuna Kim, Hyun Sook Hong and Youngsook Son6. Small molecules: Controlling cell fate and functionBaisong Lu and Anthony Atala7. Small RNA Delivery for In Situ Tissue RegenerationNaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee8. Micro and Nano Topographical cues guiding biomaterial host responseDeepak M. Kalaskar and Feras Alshomer9. Mechanobiology and Mechanotherapy in Tissue EngineeringRei Ogawa10. A biomimetic strategy to design biomaterials for in situ tissue regenerationJi Hyun Kim and Sang Jin Lee11. Impact of Matrix Dynamic Properties on Stem Cell ViabilityMarc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu12. Cell-free Scaffolds for In situ Tissue RegenerationSeung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial DesignT. Konrad Rajab and Harald Ott14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous CellsSolaiman Tarafder and Chang H. Lee15. Bioengineered strategies for tendon regenerationAna I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes16. Volumetric Muscle Repair In SituLindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee,  James J. Yoo and Anthony Atalaa17. Mending The Heart Through In Situ Cardiac RegenerationJeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou18. Skin Wound Healing – Skin Regeneration with Pharmacological Mobilized Stem CellsZhaoli Sun and George Melville Williams19. In situ renal regenerationHung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo20. Regulatory Aspects: regulation aspects of cell-free biomaterial implantsNan Zhang, Alexander Baume, Richard Payne, Julie Allickson21. Business Perspective – case study:  commercialized cell-free cardiovascular implantAlexander Sheehy, Byron Lambert and Richard Rapoza