In Situ Tissue Regeneration

Dr. Lee has extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. His research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. Dr. Lee’s research team also demonstrated the principle of “in situ tissue regeneration” that is to take advantage of the body’s own regenerating capacity by using the host's ability to mobilize endogenous stem cells to the site of injury. Currently, his research has focused on development of strategies for in situ tissue regeneration in terms of mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system from the perspective of regenerative medicine and tissue engineering. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

• 1. Fundamentals of In Situ Tissue RegenerationSang Jin Lee, James J. Yoo and Antony Atala2. Stem Cell HomingMariusz Z. Ratajczak and Ahmed A. Ismail3. Immunology – Host Responses to BiomaterialsJohn D. Jackson4. Foreign Body Reaction and Stem Cell ResponsesAshwin Nair and Liping Tang5.  Roles of endogenous growth factors and small peptides in in situ tissue regenerationSuna Kim, Hyun Sook Hong and Youngsook Son6. Small molecules: Controlling cell fate and functionBaisong Lu and Anthony Atala7. Small RNA Delivery for In Situ Tissue RegenerationNaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee8. Micro and Nano Topographical cues guiding biomaterial host responseDeepak M. Kalaskar and Feras Alshomer9. Mechanobiology and Mechanotherapy in Tissue EngineeringRei Ogawa10. A biomimetic strategy to design biomaterials for in situ tissue regenerationJi Hyun Kim and Sang Jin Lee11. Impact of Matrix Dynamic Properties on Stem Cell ViabilityMarc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu12. Cell-free Scaffolds for In situ Tissue RegenerationSeung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial DesignT. Konrad Rajab and Harald Ott14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous CellsSolaiman Tarafder and Chang H. Lee15. Bioengineered strategies for tendon regenerationAna I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes16. Volumetric Muscle Repair In SituLindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee,  James J. Yoo and Anthony Atalaa17. Mending The Heart Through In Situ Cardiac RegenerationJeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou18. Skin Wound Healing – Skin Regeneration with Pharmacological Mobilized Stem CellsZhaoli Sun and George Melville Williams19. In situ renal regenerationHung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo20. Regulatory Aspects: regulation aspects of cell-free biomaterial implantsNan Zhang, Alexander Baume, Richard Payne, Julie Allickson21. Business Perspective – case study:  commercialized cell-free cardiovascular implantAlexander Sheehy, Byron Lambert and Richard Rapoza