Yvonne C. Martin - Böcker

Since the publication of the first edition, the field has changed dramatically. Scientists can now explicitly consider 3D features in quantitative structure-activity relationship (QSAR) studies and often have the 3D structure of the macromolecular target to guide the 3D QSAR. Improvements in computer hardware and software have also made the methods more accessible to scientists. Taking these developments into account, Quantitative Drug Design: A Critical Introduction, Second Edition shows scientists how to apply QSAR techniques at a state-of-the-art level.New to the Second Edition A new chapter on methods that identify the 3D conformations to use for 3D QSARNew discussions on partial least squares, multidimensional scaling, clustering, support vector machines, kNN potency prediction, and recursive partitioningExpanded case studies that include the results of data that has been re-analyzed using newer methodsA new case study on the discovery of novel dopaminergics with pharmacophore mapping and CoMFAA new case study on the application of CoMFA to series in which the 3D structure of the ligand-protein complex is known Based on the author’s four decades of experience in all areas of ligand-based computer-assisted drug design, this invaluable book describes how to transform ligand structure-activity relationships into models that predict the potency or activity/inactivity of new molecules. It will help you avoid traps when dealing with quantitative drug design.

This volume, the second in the "3D QSAR in Drug Design" series, aims to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the first volume. It divides into three sections dealing with: ligand-protein interactions; quantum chemical models and molecular dynamics simulations; and pharmacophore modelling and molecular similarity, respectively. Volume 3 "Recent Advances" is also divided into three sections, namely: 3D QSAR methodology - CoMFA and related approaches; receptor models and other 3D QSAR approaches; and 3D QSAR applications. More than 70 scientists have contributed nearly 40 reviews of their work and related research to these two volumes, which present coverage of recent developments in all fields of 3D QSAR.

Volumes 2 and 3 of the "3D QSAR in Drug Design" series aim to review the progress being made since the publication of the first volume. Volume 2 "Ligand-Protein Interactions and Molecular Similarity" divides into three sections dealing with: ligand-protein interactions; quantum chemical models and molecular dynamics simulations; and pharmacophore modelling and molecular similarity, respectively. This volume, Volume 3 "Recent Advances", is also divided into three sections, namely: 3D QSAR methodology - CoMFA and related approaches, receptor models and other 3D QSAR approaches; and 3D QSAR applications. More than 70 scientists have contributed nearly 40 reviews of their work and related research to these two volumes, which present coverage of recent developments in all fields of 3D QSAR.

This is a set comprising the second and third volumes in the series. They review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the first volume. Volume Two, "Ligand-Protein Interactions and Molecular Similarity", is divided into three sections dealing with: ligand-protein interactions, quantum chemical models and molecular dynamics simulations; and pharmacophore modelling and molecular similarity, respectively. Volume Three, "Recent Advances" is also divided into three sections, namely: 3D QSAR methodology - CoMFA and related approaches; receptor models and other 3D QSAR approaches; and 3D QSAR applications. More than 70 scientists have contributed nearly 40 reviews of their work and related research to these two volumes. The works present an up-to-date coverage of the latest developments in all fields of 3D QSAR.

Since the publication of the first edition, the field has changed dramatically. Scientists can now explicitly consider 3D features in quantitative structure-activity relationship (QSAR) studies and often have the 3D structure of the macromolecular target to guide the 3D QSAR. Improvements in computer hardware and software have also made the methods more accessible to scientists. Taking these developments into account, Quantitative Drug Design: A Critical Introduction, Second Edition shows scientists how to apply QSAR techniques at a state-of-the-art level.New to the Second Edition A new chapter on methods that identify the 3D conformations to use for 3D QSARNew discussions on partial least squares, multidimensional scaling, clustering, support vector machines, kNN potency prediction, and recursive partitioningExpanded case studies that include the results of data that has been re-analyzed using newer methodsA new case study on the discovery of novel dopaminergics with pharmacophore mapping and CoMFAA new case study on the application of CoMFA to series in which the 3D structure of the ligand-protein complex is known Based on the author’s four decades of experience in all areas of ligand-based computer-assisted drug design, this invaluable book describes how to transform ligand structure-activity relationships into models that predict the potency or activity/inactivity of new molecules. It will help you avoid traps when dealing with quantitative drug design.

Volumes 2 and 3 of the 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum Chemical Models and Molecular Dynamics Simulations, and Pharmacophore Modelling and Molecular Similarity, respectively. Volume 3 (Recent Advances) is also divided into three sections, namely 3D QSAR Methodology: CoMFA and Related Approaches, Receptor Models and Other 3D QSAR Approaches, and 3D QSAR Applications. More than seventy distinguished scientists have contributed nearly forty reviews of their work and related research to these two volumes which are of outstanding quality and timeliness. These works present an up-to-date coverage of the latest developments in all fields of 3D QSAR.