Alzheimer, demens

Denna tredje upplaga har bland annat utökats med kapitel om palliativ vård och ledarskapets betydelse för att skapa ett personcentrerat vårdklimat. Boken är omarbetad efter det aktuella kunskapsläget och innehåller flertalet referenser, vilket möjliggör ytterligare fördjupning i ämnet.Omvårdnad för personer med demenssjukdom utgår från det mänskliga mötet och vår förmåga att se in i, och förstå, den andres livsvärld. Boken ger läsaren redskap som underlättar i detta möte. I fokus står personens upplevelse av att drabbas, upplevelsen av att vara anhörig men även olika aspekter av vårdandet är centrala. Innehållet genomsyras av ett personcentrerat och hälsofrämjande förhållningssätt, samt betonar värdegrundens, vårdmiljöns och ledarskapets betydelse. Några kapitel har fokus på existentiella aspekter och vårdfilosofi, medan andra är mer konkreta och praktiska. Sist i boken finns ett kapitel som översiktligt beskriver de olika demenssjukdomarna. Sammantaget kompletterar kapitlen varandra och ger stöd för både varandet och görandet i personalens möte med dessa personer. Kapitlen syftar också till att stimulera till eftertanke och reflektion.Målgruppen är sjuksköterskestudenter på grundnivå och avancerad nivå, men även andra yrkeskategorier som möter personer med demenssjukdom i sitt arbete har nytta av boken.

Boken om demenssjukdomar utgår från en personcentrerad vård och omsorg av personer med demenssjukdom.

Boken beskriver nya diagnoskriterier och riktlinjer för utredning och behandling samt de senaste rönen inom omvårdnadsforskning. Den tar dessutom upp fundamental vård och omsorg, miljöns betydelse, aktiviteter i vardagslivet, gemensam värdegrund och arbetssätt, palliativ vård, vårdens organisation, stöd till närstående, förbättringskunskap och teamarbete samt olika juridiska frågeställningar.

Boken om demenssjukdomar vänder sig till såväl blivande som yrkesverksamma sjuksköterskor, fysioterapeuter, arbetsterapeuter och läkare som vill bedriva en god och personcentrerad vård och omsorg baserad på de senaste rönen inom området. Den lämpar sig även väl för studerande inom yrkeshögskolan och andra utbildningar inom ämnesområdet.

Om författarnaHans Basun, tidigare överläkare och demensforskare vid Akademiska sjukhuset, Uppsala, professor i geriatrik vid Uppsala universitet.

Margareta Skog, leg. sjuksköterska, med.dr med inriktning mot omvårdnad av äldre samt fil.mag. i vårdpedagogik.

Lars-Olof Wahlund, professor i geriatrik vid Karolinska institutet.

Helle Wijk, leg. sjuksköterska, doktor i medicinsk vetenskap, professor och universitetslektor vid Sahlgrenska akademin, Göteborgs universitet/Sahlgrenska universitetssjukhuset.

Faktabok om de vanligaste demensdiagnoserna och vilka behov de olika patientgrupperna har.

Demenssjukdom är ett samlingsnamn för många olika tillstånd som påverkar hjärnan. Numera benämner man dem också som kognitiva sjukdomar. Demenssjukdom är en av de vanligaste folksjukdomarna och ses som en av världens stora hälsoutmaningar. Det krävs ökad kunskap för att möta och vårda den växande gruppen av personer som insjuknar. Därför finns den här boken.

Detta är demenssjukdom – fakta om kognitiva sjukdomar presenterar de fem vanligaste demensdiagnoserna och vilka behov de olika patientgrupperna har. Den beskriver också symtom som ofta misstolkas som demenssjukdom och förklarar BPSD, beteendemässiga och psykiska symtom vid demens.

Boken tar bland annat upp begreppet kognitiv funktionsnedsättning, Alzheimers sjukdom, vaskulär demens, frontallobsdemens, Parkinsons sjukdom, Lewykroppsdemens, PTSD, intellektuell funktionsnedsättning och Downs syndrom.

Budskapet är att en ökad medvetenhet om vad kognitiva sjukdomar innebär ger större möjlighet till en personcentrerad vård och omsorg. Boken kan även användas som uppslagsbok och varje kapitel avslutas med reflektionsfrågor.

Boken vänder sig till yrkesverksamma som möter personer med demenssjukdom och kognitiv svikt. Den kan också läsas av närstående. Denna andra upplaga är uppdaterad med ny forskning, nya begrepp och ett nytt stycke om känslor, både positiva och negativa.

Margareta Skog är leg. sjuksköterska och med.dr i omvårdnad med inriktning mot äldre. Hon har arbetat som omvårdnadsansvarig på Tema Åldrande på Karolinska Universitetssjukhuset och har tidigare varit lektor på Sophiahemmet Högskola, vårdforskningschef Stockholms Borgerskap samt rektor för Silviahemmet.

Personcentrerad omvårdnad handlar om att få individen att känna sig unik och sedd genom hela livet. Den här boken ger djupare insikter i personcentrerad vård av personer med en demenssjukdom. Teoretiska resonemang illustreras och konkretiseras med personliga berättelser från demenssjukas vardag. Författaren diskuterar också hur ledning och organisering av verksamheten påverkar möjligheten att utöva personcentrerad omvårdnad i praktiken.Reflektionsfrågor och förslag på diskussionsämnen stimulerar läsaren till eftertanke över det egna yrkesutövandet och bearbetning av kunskap i vardagen. Bokens primära målgrupp är studerande på sjuksköterske-, arbetsterapeut- och fysioterapeutprogrammen. Den kan även vara aktuell på andra hälso- och sjukvårdsutbildningar samt för vård- och omsorgspersonal i den kommunala hälso- och sjukvården och inom specialistsjukvården.

Samtal mellan vårdpersonal och personer med demenssjukdom kan ofta skapa missförstånd. Därför ger kunskap om kommunikationens betydelse ökad trygghet och samförstånd. Boken ökar förståelsen för den demenssjukas språkförmåga och språksvårigheter. Den förmedlar också hur viktig den ordlösa kommunikationen är. Den tar avstamp i forskning men bygger framför allt på röster från demensvårdens vardag. Kommunikation och demenssjukdom riktar sig till yrkesverksamma som möter personer med demenssjukdom, men är även värdefull för närstående. Observera att innehållet i denna bok är identiskt med föregående upplaga.

En demenssjukdom vänder ofta upp och ned på tillvaron, även för de närmast anhöriga. Symptomen kan variera men blir med tiden alltid fler och starkare och många anhöriga får ta på sig en vårdarroll som knappast någon är förberedd på. Om demenssjukdom för anhöriga tar inte bara upp demenssjukdomens symptom och förlopp. Den ger också konkreta råd kring bemötande, svåra situationer och, inte minst, olika former av stöd till anhöriga. I boken delar personer som levt med en demenssjuk närstående med sig av sina erfarenheter. Det handlar om prövningar och sorg men också om glädje och gemenskap mitt i sjukdomen.

Vad? En djupt personlig, varm och hoppingivande vardagsskildring från en alldeles vanlig demensavdelning. En samling tankar och erfarenheter av att skapa fungerande möten och kärleksfulla relationer till personer med demenssjukdom.

För vem? För alla som jobbar i vården. För alla som är närstående eller på annat sätt kommer i kontakt med någon med demenssjukdom. För beslutsfattare som vill veta något om den verklighet som besluten gäller. För alla som dagligen läser om vårdskandaler och skräckexempel, men som alltför sällan får höra talas om de 99% av vårdens verklighet som handlar om glädje, medmänsklighet, kreativitet, humor och, ja, kärlek helt enkelt.

Av vem? Jannika Häggström är undersköterska, musiker, skribent och levnadskonstnär. I dag arbetar hon med musik och berättarkonst, dels i äldrevården och dels i andra sammanhang: föredrag, visprogram, allsång, samtal om livsfrågor.

Läs mer, eller boka ett program: www.jannika.se

En bok för dig med demenssjukdom vänder sig främst till dig som nyligen har fått en demensdiagnos. Boken innehåller konkreta tips och råd om hur du kan övervinna svårigheter i vardagen och vart du kan vända dig för att få hjälp. Flera personer med demenssjukdom berättar i boken öppenhjärtigt om sin tillvaro. Deras bakgrund, typ av demenssjukdom och tiden de levt med sin sjukdom skiljer sig åt. Vi tror och hoppas att deras erfarenheter kan hjälpa dig som är i en liknande situation. För det går att leva ett meningsfullt liv trots svår sjukdom.

After a whirlwind romance and a marriage that spanned decades, former face of ITV news, John Suchet, revealed on breakfast television that his beloved wife Bonnie was suffering with dementia, eliciting a huge response. Never had anyone spoken so movingly about dementia, the thief that stole his still youthful wife on the eve of their retirement.My Bonnie was the number one bestseller in its category, according to the Sunday Times. Finally, the long awaited paperback edition is published, this time with a poignant new epilogue updating us on Bonnie and John’s journey through the illness. The Mail on Sunday calls My Bonnie ‘remarkable’; ‘an act of living resistance’ says the Observer.My Bonnie is a heart-rending and uplifting read, alternating between Bonnie and John’s intense love story and the progression of the illness. When he first met Bonnie, John was bowled over by her Grace Kelly-esque poise and radiance. An exotic, and married, American beauty, she seemed beyond his reach. He had no idea, however, that his love was returned; even less suspected that the two of them would one day be together, and that for 26 years, every moment would be intense, perfect, and shared. Described by readers as ‘astonishingly honest’ and a ‘personal, beautiful love story’, John’s moving account of how his wife, barely past middle age, was diagnosed out of the blue with dementia, a disease usually associated with the elderly, remains full of joy, despite the tragedy.Finally united, their marriage was passionate and anyone could see that John admired and adored Bonnie and that she loved him right back. They looked forward to their golden years when they could finally be with each other without distractions or obstacles. But the bewildering and gradual seizure of Bonnie’s mind stole away their hopes of growing old together and made each day a struggle. And yet Bonnie’s sense of humour and natural warmth constantly triumphs.

An unforgettable tribute to the unbreakable bond between a father and son When Simon McDermott first noticed his dad Ted’s sudden flares of temper and fits of forgetfulness, he couldn’t have guessed what lay ahead. Then came the devastating, inevitable diagnosis of Alzheimer’s. The dad Simon knew seemed to be drifting further away, and he had no idea how to reach him.Then, one day in the car, Simon hit play on Ted’s favourite song. And just like that, they were simply two mates driving around Blackburn, singing at the top of their lungs. That moment would change the course of their lives forever.Simon filmed their adventure, uploaded the video to YouTube and woke up to messages, tweets and his phone ringing off the hook. Their carpool karaoke had gone viral all the way across the globe.But a record deal, Pride of Britain Awards, over £130,000 raised for The Alzheimer’s Society and a Top 10 single later, Simon was still losing Ted. That’s when he made a decision. His Dad – the storyteller of his childhood and his best friend – couldn’t tell his own story, so Simon would tell it for him. This is that story.Full of poignant moments, the ups and downs of family life and treasured memories, The Songaminute Man is a story of two halves: a celebration of the man Ted was, and a powerful and moving account of caring for a loved one.

A definitive guide to navigating each stage of Alzheimer's and dementia for the recently diagnosed and their caregivers, from international dementia, memory and healthy ageing expert Dr Zaldy Tan.International memory and Alzheimer’s disease specialist Dr Zaldy Tan tackles everything you need to know about living well with Alzheimer’s and dementia, including: Preparing for an initial assessmentUnderstanding phases of cognitive declinePlanning medical careHandling home safety and fall preventionSupporting your loved one at each stageNew treatments and coping modalities everyone should knowHe also shares stories of hope from the remarkable individuals and families he’s treated over the years, describing how they handled both difficult changes and incredible triumphs after diagnosis. Written with warmth and understanding, Dr Tan offers support, guidance and comfort each step of the way.

Emmy-award winning broadcast journalist and leading Alzheimer's advocate Meryl Comer's Slow Dancing With a Stranger is a profoundly personal, unflinching account of her husband's battle with Alzheimer's disease that serves as a much-needed wake-up call to better understand and address a progressive and deadly affliction. When Meryl Comer's husband Harvey Gralnick was diagnosed with early onset Alzheimer's disease in 1996, she watched as the man who headed hematology and oncology research at the National Institutes of Health started to misplace important documents and forget clinical details that had once been cataloged encyclopedically in his mind. With harrowing honesty, she brings readers face to face with this devastating condition and its effects on its victims and those who care for them. Detailing the daily realities and overwhelming responsibilities of caregiving, Comer sheds intensive light on this national health crisis, using her personal experiences-the mistakes and the breakthroughs-to put a face to a misunderstood disease, while revealing the facts everyone needs to know.Pragmatic and relentless, Meryl has dedicated herself to fighting Alzheimer's and raising public awareness. "Nothing I do is really about me; it's all about making sure no one ends up like me," she writes. Deeply personal and illuminating, Slow Dancing With a Stranger offers insight and guidance for navigating Alzheimer's challenges. It is also an urgent call to action for intensive research and a warning that we must prepare for the future, instead of being controlled by a disease and a healthcare system unable to fight it.

A top neuroscientist’s science-driven plan on how to take better care of your brain, and, in doing so, how to enhance your memory, lose excess weight, and increase your energy and vitality. Build your best health and life possible by taking care of your brain.Your brain is the most essential organ in your body.  The brain and spinal cord are intimately connected to every bodily system and organ, so when it is balanced everything in your body and mind will function more efficiently.  It’s vitally important to take proactive steps now, or you risk losing everything, including your ability to think clearly, be creative, remember details, solve problems, and retain your memory.In Biohack Your Brain, leading neuroscientist Dr. Kristen Willeumier reveals how you can change your brain by making simple and easy modifications to your lifestyle. Combining clinical experience with revolutionary science, she details how biohacking your brain can boost your cognitive performance and so much more.Dr. Willeumier’s essential guidebook shows you the most effective techniques to prevent memory loss and neurodegenerative disorders like Alzheimer’s disease—and even how to overcome negative thoughts and stress. Through research and case studies, you’ll learn how to upgrade your nutritional choices along with the effective use of supplements, brain games, and physical activity to overcome cognitive damage, whether it’s from previous injuries, such as a concussion or a bad fall, or from the effects of living in modern day times.Dr. Willeumier shares her own story alongside those from the NFL players and other clients she has worked with to help you leverage the latest research to find personal solutions. Biohack Your Brain is a groundbreaking plan for revitalizing, nourishing, and rejuvenating your most essential asset.

Reveals the hidden connection between many of the diseases of aging—inflammation--and presents a complete program for maintaining good health

Explains the cutting-edge research that reveals inflammation as the culprit behind many diseases related to aging, including heart disease, osteoporosis, Alzheimer’s Disease, and even cancer and asthma.

Outlines a complete program for keeping inflammation to a minimum—what foods to eat, recommended supplements, weight control, and which medications to take and which to avoid. Includes a head-to-toe guide of ways to prevent or reduce inflammation.

Based on its author's four-year study and 15 years of experience in Alzheimer's and dementia-related care, Alzheimer's Activities That Stimulate the Mind is the only book offering exercises appropriate to each of the four stages of the disease. It features hundreds of exercises across an array of areas and disciplines, including arts and crafts, community outings, physical activity, religion and spirituality, grooming, gardening, music, and many more.

The compassionate and practical guide to managing dementia and Alzheimer's, from a clinical psychologist and Sunday Times bestselling author.Dementia is a little understood illness but, while there is currently no cure, much can be done to support wellbeing and maintain quality of life for people living with this condition.In Contented Dementia, clinical psychologist and bestselling author, Oliver James, outlines a groundbreaking and practical method for managing dementia that will allow both sufferer and carer to maintain the highest possible quality of life, throughout every stage of the illness.The SPECAL method (Specialised Early Care for Alzheimer’s) was developed to help carers, families and professionals respond to memory loss and behavioural changes with understanding, confidence, and a personalised approach.The method is based on a simple but powerful principle: although recent memory fades, emotional memory and long-term memories often remain strong. By working with, rather than against, the reality experienced by the person with dementia, SPECAL helps reduce distress, improve communication and create a calmer, more contented daily life.Drawing on real-life examples and user-friendly tried-and-tested methods, Contented Dementia provides essential information and guidance for families, caregivers and healthcare professionals seeking a more positive approach to dementia care.Praise for Contented Dementia:‘A revolutionary new way of treating dementia [that] brings amazing benefits for patients and carers alike’ Guardian‘An indispensable handbook for anyone coping with the effects of dementia and who wants to keep a sufferer as happy as is humanly possible’ Daily Express‘Explains a revolutionary way to care for dementia patients . . . tender techniques that can ease absent minds’ Telegraph‘Anyone who wants help in caring for the condition will find this excellent work a revelation’ Mail on Sunday‘Shows how to minimize distress and manage dementia…I expected this book to be depressing; it is exactly the opposite.’ The Independent

If you drink apple juice with cinnamon, look after your gums, read, dance and take an aspirin a day - you are well on your way to preventing Alzheimer's disease. When bestselling author Jean Carper discovered she had the Alzheimer's gene, she was determined to find out if there was anything she could do to help herself. In this book, she teaches readers how to take simple and effective steps to prevent Alzheimer's disease, providing the scientific rationale behind the tools in the book and detailing instructions on how readers can apply particular steps to their lives.Based on the latest scientific findings and distilled into 100 short chapters, 100 Simple Things You Can do to Prevent Alzheimer's is full of surprising strategies for battling age-related memory loss, including drinking apple juice, taking care of your gums and even simply trying new things.

With recent advances of modern medicine, more people reach the "elderly age� around the globe, and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into the pathogenesis of this devastating group of diseases.

Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area.

Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer's disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer's disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics.

Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer's disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer's Disease and illustrating the paradigm necessary to ensure future research and treatment success.

The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer's Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer's Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders.

Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer's disease research to provide a single, comprehensive, and balanced resource

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline.

It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer's disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

Provides the first volume to link genetic and environmental risk factors for Alzheimer's disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer's disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management.

This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics.

Comprehensive reference detailing neuroprotection in Alzheimer's Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer's Disease

Consequences of Intracellular Amyloid in Alzheimer's Disease addresses one of the more currently unresolved aspects confounding Alzheimer's research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity.

Following up on Dr. D'Andrea's first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer's Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer's Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer's is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer's

Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function is a complete guide to the manifold effects of exercise and physical activity on the aging brain. Cognitive decline and motor impairment, onset of diseases and disorders, and even changes in family structure and social settings that occur as we age can all impact activity levels, yet continued physical activity is crucial for successful neurological functioning.

This book examines the role that exercise and physical activity play in halting or modulating the deleterious effects of these numerous aging concerns by first examining the current state of research into how exercise manifests physical changes in the brain. It then discuss how physical activity combines with other lifestyle factors to benefit the aging brain, including nutrition, computerized brain training, and social engagement. Most significantly, it also covers how physical activity can serve as therapy to help alleviate the symptoms of various neurological diseases impacting aging populations, with particular emphasis on Alzheimer's disease and age-related cognitive decline.

The book provides broad coverage of the effects of exercise and physical activity on the aging brain, its therapeutic effects, and the many factors that influence the aging process.

Presents research scientists with a complete understanding of the role of exercise in healthy brain aging Considers the roles of nutrition, the mind-body connection, and other lifestyle factors Presents a major resource for exercise and physical activity in the neurological health of older adults Provides a synopsis of key ideas associated with the many aspects of physical activity, along with lifestyle factors that can modify neurological diseases and age-related neurological decline

Better Living With Dementia: Implications for Individuals, Families, Communities, and Societies highlights evidence-based best practices for improving the lives of patients with dementia. It presents the local and global challenges of these patients, also coupling foundational knowledge with specific strategies to overcome these challenges. The book examines the trajectory of the disease, offers stage-appropriate practices and strategies to improve quality of life, provides theoretical and practical frameworks that inform on ways to support and care for individuals living with dementia, includes evidence-based recommendations for research, and details global examples of care approaches that work.

Weaves research evidence and theories with practical know-how Identifies support strategies for home, community, and health care settings Provides stage-appropriate strategies relative to dementia severity Summarizes dementia pathology, diagnosis, and progression Considers the changing needs of both the individual with dementia and family and formal caregivers Offers evidence-informed recommendations for research, practice, policy, and how to make things better at home, in the community, in healthcare and service settings, and through national policies Provides local and global exemplars of what works Provides case vignettes to illustrate key points with real examples Contains brief conversations with national and international experts

A Paradigm Shift to Prevent and Treat Alzheimer's Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer's disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years.

These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth.

This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model.

A Paradigm Shift to Prevent and Treat Alzheimer's Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers.

Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer's disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer's disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

EEG-Based Diagnosis of Alzheimer Disease: A Review and Novel Approaches for Feature Extraction and Classification Techniques provides a practical and easy-to-use guide for researchers in EEG signal processing techniques, Alzheimer's disease, and dementia diagnostics. The book examines different features of EEG signals used to properly diagnose Alzheimer's Disease early, presenting new and innovative results in the extraction and classification of Alzheimer's Disease using EEG signals. This book brings together the use of different EEG features, such as linear and nonlinear features, which play a significant role in diagnosing Alzheimer's Disease.

Includes the mathematical models and rigorous analysis of various classifiers and machine learning algorithms from a perspective of clinical deployment Covers the history of EEG signals and their measurement and recording, along with their uses in clinical diagnostics Analyzes spectral, wavelet, complexity and other features of early and efficient Alzheimer's Disease diagnostics Explores support vector machine-based classification to increase accuracy

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia