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This is the first textbook dedicated to CEST imaging and covers the fundamental principles of saturation transfer, key features of CEST agents that enable the production of imaging contrast, and practical aspects of preparing image-acquisition and post-processing schemes suited for in vivo applications. CEST is a powerful MRI contrast mechanism with unique features, and the rapid expansion it has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical, translational, and clinical CEST imaging. The book provides an illustrated historical perspective by leaders at the five key sites who developed CEST imaging, from the initial saturation transfer NMR experiments performed in the 1960s in Stockholm, Sweden, described by Sture Forsén, to the work on integrating the basic principles of CEST into imaging by Robert Balaban, Dean Sherry, Silvio Aime, and Peter van Zijl in the United States and Italy.The editors, Drs. Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte, and Peter C. M. van Zijl, have been pioneers developing this field at the Johns Hopkins University School of Medicine and the Kennedy Krieger Institute including contributions to Nature Medicine, Nature Biotechnology, Nature Materials, and the Proceedings of the National Academy of Sciences. As recognition for their initial development of the field, Drs. van Zijl and Balaban were awarded the Laukien Prize in April 2016, established in 1999 to honor the memory of Professor Gunther Laukien, a co-founder of Bruker Biospin GmbH.

The field of C-nanoparticles toxicity is, at present, fragmented and contradictory, oscillating between enthusiastic raptures and bitter disappointments. This important book presents an overall, unitary view of the carbon nanoparticle world, in which both the positive and negative aspects of these recently discovered nanomaterials are critically described and elucidated.The book provides an exhaustive account of C-nanotubes toxicity, mechanisms of toxicity and biocompatibility towards human and animal organisms as well as the entire biological environment. The detailed description of the physicochemical properties of these nano-objects will help facilitate discussion on their future applications in the biomedical field.This book is unique in its understanding, interpretation and analysis of the mechanisms related to the physicochemical behavior of C-nanotubes, as its aims is to let readers be in contact with C-nanoparticles in order for them to benefit from the many advantages these nanostructures can offer in the aforesaid field. Contributors include experts in the study of materials biocompatibility and toxicity, mainly because the book concerns carbon-nanoparticles toxicity.

This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g., diabetes, cancer, inflammation) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. From this concise book, readers will gain an insight into the basics of nanoparticle preparation and find a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Nanotechnology is one of the most important growth areas of this century. Nanoscience, the science underpinning nanotechnology, is a multidisciplinary subject covering atomic, molecular and solid state physics, and much of chemistry. Nanostructures are known to exhibit novel and improved material properties, fundamentally because the physical and chemical properties are very different when dimensions are reduced to the nanometer range. Suitable for undergraduate students or advanced high school students, this book introduces the basic principles and knowledge needed for students to understand science at the nanoscale. Many ideas proposed in nanotechnology are frontier and futuristic, although some have immediate technological applications. The core scientific principles of all nanotechnology applications, however, are grounded in physics and chemistry. This practical, student-friendly introduction helps students recognize the connections among these various disciplines and how they play a part in nanoscience and technology.

In recent decades, dendrimers — free-shaped synthetic macromolecules — have garnered a great deal of scientific interest because of their unique molecular nanostructure. Used in a variety of scientific applications, dendrimers are now widely regarded as a safer, more precise and more effective way to practice medicine.This book compiles and details cutting-edge research in science and medicine from the interdisciplinary team of the Michigan Nanotechnology Institute for Medicine and Biological Sciences, which is currently revolutionizing drug delivery techniques through the development of engineered nanodevices. Edited by Istvan J. Majoros and James R. Baker Jr, two prominent nanotechnology researchers, this book will appeal to anyone involved in nanotechnology, macromolecular science, cancer therapy or drug delivery research.

This book highlights state-of-the-art qubit implementations in semiconductors and provides an extensive overview of this newly emerging field. Semiconductor nanostructures have huge potential as future quantum information devices as they provide various ways of qubit implementation (electron spin, electronic excitation) as well as a way to transfer quantum information from stationary qubits to flying qubits (photons). Therefore, this book unites contributions from leading experts in the field, reporting cutting-edge results on spin qubit preparation, read-out and transfer. The latest theoretical as well as experimental studies of decoherence in these quantum information systems are also provided. Novel demonstrations of complex flying qubit states and first applications of semiconductor-based quantum information devices are given, too.

This book presents the material necessary for understanding the physics, operation, design, and performance of modern MOSFETs with nanometer dimensions. It offers a brief introduction to the field and a thorough overview of MOSFET physics, detailing the relevant basics. The authors apply presented models to calculate and demonstrate transistor characteristics, and they include required input data (e.g., dimensions, doping) enabling readers to repeat the calculations and compare their results. The book introduces conventional and novel advanced MOSFET concepts, such as multiple-gate structures or alternative channel materials. Other topics covered include high-k dielectrics and mobility enhancement techniques, MOSFETs for RF (radio frequency) applications, MOSFET fabrication technology.

This book provides a broad overview of nanotechnology as applied to contemporary electronics and photonics. The areas of application described are typical of what originally set off the nanotechnology revolution. An account of original research contributions from researchers all over the world, the book is extremely valuable for gaining an understanding of the latest developments in applied nanotechnology. Clearly structured and readable, the book is useful for both students and researchers alike: students can learn about the various aspects of nanotechnology, and professional researchers can update themselves on the new developments in this dynamic field.The book covers nanoscale materials and devices for both electronics and optical technologies. The emphasis throughout is on experimental methods rather than theoretical modeling. The material will provide food for thought for researchers and research students keen to develop new technologies at the ultra-small scale and to open up new avenues for research.

Nanoscale materials are showing great promise in various optoelectronics applications, especially the fast-developing fields of optical communication and optical computers. With silicon as the leading material for microelectronics, the integration of optical functions into silicon technology is a very important challenge. This book concentrates on the optoelectronic properties of silicon nanocrystals, associated phenomena and related topics, from basic principles to the most recent discoveries. The areas of focus include silicon-based light-emitting devices, light modulators, optical wavevguides and interconnectors, optical amplifiers and memory elements. The book comprises theoretical and experimental analyses of various properties of silicon nanocrystals, research methods and preparation techniques, and some promising applications.

This book provides a comprehensive overview of the computational physics for nanoscience and nanotechnology. Based on MATLAB and the C++ distributed computing paradigm, the book gives instructive explanations of the underlying physics for mesoscopic systems with many listed programs that readily compute physical properties into nanoscales. Many generated graphical pictures demonstrate not only the principles of physics, but also the methodology of computing.

The book investigates QDs and SWCNTs using quantum-chemical calculations that describe intricate details of excited-state phenomena and provides information about the mechanisms that occur on the atomic level and that are extremely difficult, if not impossible, to probe experimentally. It delivers, consistently and coherently, a novel approach to nanomaterials which is promising for today's technologies as well as their future. This approach elegantly overcomes computational difficulties known in the field and shares ways to reach top performance in the description of combined quantum effects of molecular vibrations and exciton formation on realistic-size numerical models. The reader will acquire an understanding of the pioneering methodology supported by most recent original results, prospectively applicable to the design of new nano-devices.

In this book, the authors concentrate on the surface Plasmon (SP) waveguide configurations ensuring nanoscale confinement and review the current status of this rapidly emerging field, considering different configurations being developed for nanoscale plasmonic guides and circuits. Both fundamental physics and application aspects of plasmonics are reviewed in detail by the world's leading experts. A unique feature of this book is its strong focus on a particular subfield of plasmonics dealing with subwavelength (nanoscale) waveguiding, an area which is especially important in view of the explosively growing interest in plasmonic interconnects and nanocircuits.

This book offers a fundamental and comprehensive overview of nanomedicine from a systems engineering perspective, making it the first book in the field of quantitative nanomedicine based on systems theory. The book starts by introducing the concept of nanomedicine and provides basic mathematical modeling techniques that can be used to model nanoscale biomedical and biological systems. It then demonstrates how this idea can be used to model and analyze the central dogma of molecular biology, tumor growth and the immune system. Broad applications of the idea are further illustrated by Bayesian networks, multiscale and multiparadigm modeling and AFM engineering.

Over the past decade biophotonics has appeared as a new department within the academic structure across the globe. With experimental work going back for more than a century, application of the scientific method has shown the importance of biophotonics within biological and medical practice. At the same time, a new mathematical description of physics and biophysics has emerged. Self-Field Theory (SFT) describes the role of photon as a binding agent between an electron and a proton within atomic structures. SFT is being rapidly accepted by the physics community as a distinct physical theory. This is now an alternative view, in addition to classical electromagnetics and the quantum theories, that forms the basis of a chemical bond. Atomic chemistry underpins biochemistry, the pharmaceutical approach to medical therapy, and has been a staple of biological and medical knowledge over the 20th century. The biophoton within SFT provides another layer of structural organization that sits underneath atomic chemistry. This book is the first to describe SFTs role within biophotonics and as such provides a theory of biophotonics capable of describing a wide range of experimental biophotonic phenomena. Inside the Photon: A Journey towards Health describes the newly discovered layer of biophotonics underlying all atomic chemistry and biochemistry. As with the variety of snowflakes, the range in biological species within flora for instance is dependent on this biophotonic layer of interaction within atomic and biomolecular structures. A new range of energies that can be balanced only within the biophotonic states are responsible for these innumerable varieties of biological species. The phonon, the quantum of acoustic, or vibrational, energy is also described and given status alongside the photon. Hence the ‘biophonon’ sits aside the biophoton as an element within biological structures. Sounds can create structure in the same way biophotons can use structure to communicate. Therapies such as homeopathy, acupuncture, traditional Chinese medicines are given fresh impetus including putative understanding of mechanism. Mitosis is understood via the cell cycle and how electric, acoustic, and magnetic fields can induce changes at the biophotonic level. The possibility arises of medical therapy without invasive surgery and without the side effects of drug-based therapies.

The challenge of providing adequate power on an indefinite basis without causing long-term damage to the environment requires a versatile means of energy conversion and storage. As such, electrical energy storage is becoming more vital today than at any time in human history. Electrochemical systems, such as batteries, supercapacitors, fuel cells, and photoelectrochemical cells, can help meet this objective. Future generations of rechargeable lithium batteries will be required to power portable electronic devices, store electricity from renewable sources, and serve as a vital component to pursuing electric mobility in the future to reduce fossil fuel demand and mitigate environmental issues. In this context, engineering of new materials, especially at the nanoscale, has become imperative to achieve enhanced energy and power density to meet the future challenges of energy storage. This book outlines the state of the art of nanoscale aspects of advanced energy storage devices, such as lithium-ion batteries, including microbatteries and electrochemical supercapacitors. It focuses on various fundamental issues related to device performance of various positive and negative electrode materials, with special reference to their nanoscale advantages. It also includes fundamentals and processing techniques with regard to synthesis, characterization, physical, and electrochemical properties, and applications of nanoscale materials pertaining to advanced electrochemical power sources. A variety of advanced nanomaterials, such as transition metal oxides, phosphates, silicates, and conversion electrodes, together with some special nanomaterials such as carbon nanotubes, nanorods, and mesoporous carbons are discussed by many notable authorities in the field.

This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

This book serves as a guide for practicing engineers, researchers, and students interested in MEMS devices that use biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials.Biomaterials for MEMS highlights important features and issues of biomaterials that have been used in MEMS and biomedical areas. Hence this book is an essential guide for MEMS engineers or researchers who are trained in engineering institutes that do not provide the background or knowledge in biomaterials. The topics include fabrication of devices using biomaterials; biocompatible coatings and issues; thin-film biomaterials and MEMS for tissue engineering; and applications involving MEMS and biomaterials.

Nanoparticles and nano-sized materials created by nanotechnology (NT) have been considered unique and sole solutions to overcome the limitations of other technologies and widen their applications. Although these materials have been widely used in environmental technology (ET), most environmental applications of nanoparticles were limited to the fabrication of nano-sensors for the detection of volatile organic compounds (VOC) and as nano-sized catalysts for air purification systems. As a result, the use of nanoparticles for the direct removal of pollutants from contaminated soil and wastewater has seldom been reported. However, environmental processes for soil remediation, wastewater treatment, and air purification strongly need innovative new materials to highly improve their performance and efficiency. So, demands for materials created by NT in ET are stronger than ever. Advances in Nanotechnology and the Environment presents the possible applications of nano-sized materials in all environmental processes, providing the most reliable guideline for the selection of nanomaterials to improve the efficiency of environmental processes. It focuses on the design of specific nanomaterials for environmental processes and pollutants. It presents the impact and influence of nanomaterials on the environment and discusses how to avoid causing secondary contamination by the use of nanomaterials. The book provides proper information about nanomaterials for potential users who will use and apply nanomaterials in ET.

As the elderly population increases, the importance of creating sophisticated information support to humans with limited sensing performance has also grown. This book discusses human and artificial sensing in conjunction with human perception capabilities (auditory, taste, smell, vision, and touch). It also discusses the fusion of this sensing information to find answers to questions such as how we can increase our human "fuzzy" decision capability (perception). The book presents intelligent new technologies that can enhance the natural sensing, perception, and mobility abilities of humans, allowing them to have healthier, more productive, safer lives.

Biophysics is a new way of looking at living matter. It uses quantitative experimental and theoretical methods to open a new window for studying and understanding life processes.This textbook gives compact introductions to the basics of the field, including molecular cell biology and statistical physics. It then presents in-depth discussions of more advanced biophysics subjects, progressing to state-of-the-art experiments and their theoretical interpretations.The book is unique by offering a general introduction to biophysics, yet at the same time restricting itself to processes that occur inside the cell nucleus and that involve biopolymers (DNA, RNA, and proteins). This allows for an accessible read for beginners and a springboard for specialists who wish to continue their study in more detail.

This book provides an actual overview of structure, function, and application of carbohydrate-modifying biocatalysts. Unlike amino acids and nucleic acids, carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure and a lack of suited experimental methods for structure determination. Meanwhile, the situation changed with increasing knowledge about carbohydrates, glycoconjugates, and carbohydrate-modifying enzymes together with the key roles they play in biological processes such as recognition, signal transduction, and immune responses. An outcome of research activities in glycoscience, which, at the same time, is of great general interest, is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases.

This textbook links characteristic features of atomic and electronic structures of disordered semiconductors to the device design process. It begins with a description of general concepts of disordered semiconductors, their atomic structures, the structure of energy bands, and their defects, as well as their electrical, optical, and photovoltaic properties. Since weak sensitivity to impurities is a distinguishing feature of disordered semiconductors, methods of property control and thin-film preparation methods are the areas of focus. Finally, applications of disordered semiconductors in various devices are considered.

This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotube; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensor; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction: nanoparticle-induced catalysis for DNA biosensing; basic terms regarding electrochemical DNA (nucleic acids) biosensors; screen-printed electrodes for electrochemical DNA detection: application of field-effect transistors to label free electrical DNA biosensor arrays; and electrochemical detection of nucleic acids using branched DNA amplifiers.

This book describes the fundamentals and principles of energy harvesting and provides the necessary theory and background to develop energy harvesting power supplies. It explains the overall system design and gives quantitative assumptions on environmental energy. It explains different system blocks for an energy harvesting power supply and the trade-offs. The text covers in detail different energy transducer technologies such as piezoelectric, electrodynamic, and thermoelectric generators and solar cells from the material to the component level and explains the appropriate power management circuits required in these systems. Furthermore, it describes and compares storage elements such as secondary batteries and supercapacitors to select the most appropriate one for the application. Besides power supplies that use ambient energy, the book presents systems that use electromagnetic fields in the radio frequency range. Finally, it discusses different application fields and presents examples of self-powered electronic systems to illustrate the content of the preceding chapters.

Nanoindentation is ideal for the characterization of inhomogeneous biological materials. However, the use of nanoindentation techniques in biological systems is associated with some distinctively different techniques and challenges. The book presents the basic science of nanoindentation, including the background of contact mechanics underlying indentation technique and the instrumentation used to gather mechanical data. It provides perspectives that are optimized for biological applications, including discussions on hydrated materials and adaptations for low-stiffness materials. The book also covers the applications of nanoindentation technique in biological materials. Highlighting current challenges, it concludes with an insightful forecast of the future.

This book overviews the current status of research and development activities of CNTs in nanodevices, nanomaterials, or nanofabrication. This book presents 15 state-of-the-art review articles that cover CNT synthesis technologies for growing highly orientated CNTs, chirality-pure CNTs and CNTs at a large throughput and low cost, CNT assembly techniques, CNT sorting and separation processes, CNT functionalization engineering for more functionalities, CNT fundamental properties and their practical/potential electrical, electronic, optical, mechanical, chemical and biological applications.

This book examines single-electron circuits as an introduction to the rapidly expanding field of nanoelectronics. It discusses both the analysis and synthesis of circuits with the nanoelectronic metallic single-electron tunneling (SET) junction device. The basic physical phenomena under consideration are the quantum mechanical tunneling of electrons through a small insulating gap between two metal leads, the Coulomb blockade and Coulomb oscillations — the last two resulting from the quantization of charge. The author employs an unconventional approach in explaining the operation and design of single-electron circuits.

The book covers a broad multidisciplinary arena including applications for energy conservation, materials performance enhancement, electronic circuitry, video displays, lighting, photovoltaics, quantum computing, memory, chemo- and biosensors, pharmaceuticals and medical diagnostics inter alia. It presents a comprehensive introductory overview of the photophysics, instrumentation and experimental methodology of nanomaterial luminescence. Invited experts highlight more specific advanced research areas that have either shown potential for, or have already realized, significant impact on the day-to-day aspects of modern life and the world economy.

This book concentrates on both understanding and development of nanocrystalline materials. The original relation which connects grain size and strength known as the Hall-Petch relation is studied in the nanometer grain size region. The breakdown of such a relation is a challenge. Why and how to overcome? Is the dislocation mechanism still operating when the grain size is very small approaching the amorphous limit? How do we go from the microstructure information to the continuum description of the mechanical properties.