High Throughput Screening

"…a valuable reference."-Journal of Pharmacy and Pharmacology"…a well-referenced, highly professional, comprehensive, and in-depth treatment of a relatively complex approach to the discovery of bioactive substances….…a recommended book for most private libraries of both academic and industrial pharmaceutical and agricultural chemists and biologists and a must acquisition for applicable and industrial libraries."-Journal of Medicinal Chemistry"…an excellent compendium…covering the breath of current HTS. It will serve as a standard text in the field."-Journal of Natural ProductsThis recommendable book should be of great value for the entry in high throughput screening systems in industry and research. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design.- European Journal of Pharmaceutics and Biopharmaceutics, 2000

• Natural Products as a Discovery Resource, edited by John P. DevlinChemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. DevlinMicrocollection of Plants for Biochemical Profiling, John P. DevlinEnzymes and Microbes as a Source of Chemical Diversity, Saul L. NeidlemanThe Marine Environment as a Discovery Resource, Gregg R. DietzmanCompound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. PaviaIntroduction, Michael R. PaviaRapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dörner, John M. Ostresh, Colette Dooley, and Richard A. HoughtenSynthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian HendersonParallel Organic Synthesis Using Parke-Davis' Diversomer® Method, Sheila Hobbs DeWitt and Anthony W. CzarnikRapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. ToyonagaCMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and László KovácsDesign of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. PetersonAutomating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. SmietanaCombi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen FelderAssay Technologies and Detection Methods, edited by Alfred J. KolbIntroduction, Alfred J. KoinBioassay Design and Implementation, Robert W. Wallace and Mark E. GoldmanScintillation Proximity Assays, Martino Picardo and Kelvin T. HughesFlashPlate™ Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, and Simon NgAssays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors, Maureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, and Wai Lee T. WongA Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery, Alfred J. Kolb, Jocelyn W. Burke, and Gerard MathisTime-Resolved Fluorometry: Advantages and Potentials, Ilkka HemmiläAdaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats, Janet M. Kolb, Greg Yamanaka, and Susan P. ManlyFluorescence Polarization, J. Richard Sportsman, Sandra K. Lee, Hara Dilley, and Robert BukarReporter Gene Assay Applications, Winfried ScheirerDevelopment of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction, D. K. H. Lee, E. T. Wilkinson, S. Cheifetz, and S. A. De GrandisHigh-Performance Microphysiometry in Drug Discovery, M. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D. H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, and Jana WilliamsBioanalytical Applications of BIAcore, an Optical Biosensor, Francois Legay, Patrick Albientz, and Rüdiger RidderAutomation and Robotics, edited by Alfred J. KolbIntroduction, Alfred J. KolbManagement and Service Issues of a Centralized Robotic HTS Core, John BabiakFlexible Use of People and Machines, Mark Beggs and John S. MajorBar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program, Elizabeth A. Kunysz, Melissa Lukes, and Douglas W. BonhausFactors for the Successful Integration of Assays, Equipment, Robotics, and Software, Dejan Bojanic, Wilma W. Keighley, Mike J. Russell, and Terry P. WoodAccelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?, Richard K. Brown and Andree ProulxPerspectives on Scheduling, Alain Donzel, Jorge Carmona, and L. Andrew CorkanData Retrieval, Handling, and Integration, edited by John P. DevlinIntroduction, John P. DevlinDatabase Systems, Barr E. BauerSystems Integration, Chip AlleeData Management and Tracking for Natural Product Programs, Gregg R. DietzmanLaboratory Design and Management, edited by Matthew A. SillsIntroduction, Matthew A. SillsPlanning and Implementing an HTS Program, Matthew A. Sills and Mark CrawfordEstablishing an HTS Program in a Start-up Biotechnology Company, Michael D. Boisclair, James Schultz, and Dan Maloney