Biokemisk teknik

För första gången i mänsklighetens historia kan vi nu gå in i våra gener och ändra i deras sammansättning. För sin upptäckt av gensaxen CRISPR belönades biokemiforskaren Jennifer Doudna med Nobelpriset. Genredigeringen innebär stora möjligheter för oss att kunna bota svåra sjukdomar, bekämpa pandemier och få friskare barn. Men samtidigt måste vi sätta gränser för hur långt vi kan gå med denna revolutionerande teknik. Hamnar tekniken i fel händer och utnyttjas för tvivelaktiga syften kan det få förödande konsekvenser för oss alla.

I Livets kod berättar den internationellt bästsäljande biografen Walter Isaacson om hur vårt liv förändras i grunden genom tillgången till denna revolutionerande teknik – och om den kvinna som knäckte koden.

Den nya genteknikens framväxt har gått i rasande fart. När de första genmodifierade barnen föddes i Kina 2018 blev det tydligt att mänskligheten stod inför möjligheter som vi förut bara fantiserat om. Med gensaxen crispr kan vi troligen bestämma våra barns egenskaper och slippa sjukdom och åldrande. Men det finns också risker. Hur ska vi hantera de nya verktygen som kan förändra vår arvsmassa?

Vetenskapsjournalisten Torill Kornfeldt har rest över hela världen för att träffa människorna som driver utvecklingen. Hon har besökt exklusiva fertilitetskliniker i Sydkorea, cancerläkare i Kina som experimenterar på obotligt sjuka patienter och bio-hackers i amerikanska storstäder som vill göra den nya tekniken tillgänglig för alla. I Människan i provröret undersöker hon vilka konsekvenser de senaste årens framsteg har fått och vad som väntar runt hörnet. 

Den nya genteknikens framväxt har gått i rasande fart. När de första genmodifierade barnen föddes i Kina 2018 blev det tydligt att mänskligheten stod inför möjligheter som vi förut bara fantiserat om. Med gensaxen crispr kan vi troligen bestämma våra barns egenskaper och slippa sjukdom och åldrande. Men det finns också risker. Hur ska vi hantera de nya verktygen som kan förändra vår arvsmassa?

Vetenskapsjournalisten Torill Kornfeldt har rest över hela världen för att träffa människorna som driver utvecklingen. Hon har besökt exklusiva fertilitetskliniker i Sydkorea, cancerläkare i Kina som experimenterar på obotligt sjuka patienter och bio-hackers i amerikanska storstäder som vill göra den nya tekniken tillgänglig för alla. I Människan i provröret undersöker hon vilka konsekvenser de senaste årens framsteg har fått och vad som väntar runt hörnet. 

Nobelpriset i kemi 2020, för upptäckten av ett av genteknikens skarpaste verktyg: gensaxen CRISPR/Cas9.

"En vetenskaplig thriller och fängslande läsning" Venki Ramakrishnan, ordförande för The Royal Society och tidigare mottagare av Nobelpriset i kemi

En upptäckt med potential att rädda liv men också ödelägga dem.

Inte sedan atomkraften har en ny teknologi haft så oöverskådliga konsekvenser att upphovsmännen känt sig tvungna att varna för sin upptäckt. I den här välskrivna vetenskapliga thrillern får vi följa Nobelprisvinnande Jennifer Doudna på jakt efter den stora upptäckten, en jakt som leder till svåra vägval och större makt än vi kunnat ana.

Resultatet: gensaxen CRISPR, som gör det möjligt att redigera biologisk arvsmassa nästan lika enkelt som att klippa och klistra i en text. Tekniken kan komma att användas för att stoppa hiv, bota vissa cancersorter och förebygga genetiska sjukdomar. Men också för att tillföra nya, ärftliga egenskaper hos människan -- en möjlighet som leder till oerhörda etiska utmaningar.

Den världsledande forskaren Jennifer Doudna, som tilldelades Nobelpriset i kemi 2020, berättar i Sprickan i skapelsen tillsammans med Samuel Sternberg om en av den moderna vetenskapens största upptäckter.

"Det finns en enorm kraft i gensaxen, som angår oss alla." Claes Gustafsson, ordförande i Nobelkommittén för kemi.

"Ett ovärderligt vittnesmål ... vi står i Doudnas skuld många gånger om" The Guardian

"Obligatorisk läsning för varje engagerad medborgare" New York Review of Books

"Sprickan i skapelsen, skriven av en av de främsta kvinnliga pionjärerna inom naturvetenskapen, är både olidligt spännande och skrämmande ... den här boken är en vägvisare till framtiden" Arianna Huffington

"Framtiden är i våra händer som aldrig förr, och den här boken förklarar vad som står på spel som ingen annan" George Lucas

The Definitive Guide to Chemical Reaction Engineering Problem-Solving -- With Updated Content and More Active Learning

For decades, H. Scott Fogler's Elements of Chemical Reaction Engineering has been the world's dominant chemical reaction engineering text. This Sixth Edition and integrated Web site deliver a more compelling active learning experience than ever before. Using sliders and interactive examples in Wolfram, Python, POLYMATH, and MATLAB, students can explore reactions and reactors by running realistic simulation experiments.

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About the Companion Web Site (umich.edu/~elements/6e/index.html)

Register your book for convenient access to downloads, updates, and/or corrections as they become available. See inside book for details.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

You'll welcome the rigorous project evaluation, design and operation guidelines this valuable guide puts at your disposal. Industry veteran John Cookson delivers job-tested insights into the most effective methods and provides the step-by-step details you need to put them to work.

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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

Expertly analyze failures in common materials with Failure Analysis of Engineering Materials. This investigatory/analytical tool by Charles R. Brooks and Ashok Choudhury is a time-saving, one-stop reference for engineers. A soundly written introduction to principals and practices, it’s invaluable for failure inquiries involving metals, ceramics, plastics, composites, and electronic materials. You get:

* Practical, hands-on help with selecting and justifying analytic methods* Numerous case studies that illustrate the use of analytical tools to determine the condition of the material* Comparative fractographs to help you pinpoint fracture type.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

DISCOVER all the RED-HOT areas of biotechnology!

Encompassing everything from promising new drug therapies and experimental treatment of genetic disorders to potential pandemics and bioterrorist threats, biotechnology is one of the most talked-about and exciting branches of science. And there is no faster or more effective way to master all the essential subtopics within this emerging area.

Biotechnology Demystified lets you learn at your own comfortable pace. Coverage advances logically and smoothly, from the basics of molecular and cellular biology to more complex topics. In this unique guide, learning is continually reinforced and achievement demonstrated. Multiple-choice quizzes at the ends of chapters and a final exam help guide you to topic mastery -- without stress or anxiety.

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Simple enough for a beginner, but challenging enough for an advanced student, Biotechnology Demystified is a lively and entertaining guide to understanding a science that's making the news daily!

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The latest in organic electronics-based sensing and biotechnology

Develop high-performance, field-deployable organic semiconductor-based biological, chemical, and physical sensor arrays using the comprehensive information contained in this definitive volume. Organic Electronics in Sensors and Biotechnology presents state-of-the-art technology alongside real-world applications and ongoing R & D.

Learn about light, temperature, and pressure monitors, integrated flexible pyroelectric sensors, sensing of organic and inorganic compounds, and design of compact photoluminescent sensors. You will also get full details on organic lasers, organic electronics in memory elements, disease and pathogen detection, and conjugated polymers for advancing cellular biology.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY

Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation.

A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications.

Coverage includes:

“Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). …His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. …The ample illustrations and tables also break up the text and make reading the book easier on the eyes. …concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014

“This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. …The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. …I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.