Molecular and Cellular Mechanobiology

Häftad, Engelska, 2018

Del i serien Physiology in Health and Disease

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Beskrivning

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease.

Produktinformation

Utgivningsdatum:2018-06-09
Mått:155 x 235 x 18 mm
Vikt:482 g
Format:Häftad
Språk:Engelska
Serie:Physiology in Health and Disease
Antal sidor:302
Förlag:Springer-Verlag New York Inc.
ISBN:9781493981663

Utforska kategorier

Fysiologi inom Medicin
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Innehållsförteckning

Part 1. Mechanosensors.- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane.- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress.- Cadherins in Mechanotransduction.- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus.- Part 2. Transducers.- Emerging Roles of YAP/TAZ in Mechanobiology.- Role of Rho GTPases in Mechanobiology.- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions.- Part 3. Epigenetic and Genetic Regulations in the Nucleus.- Mechanotransduction to Epigenetic Remodeling.- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration.- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression.- Part 4. Applications.- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine.- Heart Valve Mechanobiology in Development and Disease.- Molecular and Cellular Mechanobiology of Cancer.