Bokus
Sahotra Sarkar - Cut-and-Paste Genetics, Inbunden

Inbunden, Engelska, 2021

Cut-and-Paste Genetics

A CRISPR Revolution

Av Sahotra Sarkar

533 kr

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Beskrivning
The emergence of CRISPR/Cas9 technology has revolutionized gene editing. The Nobel prize for chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna, the scientists responsible for its discovery, in 2020 and it is considered the frontier of sophisticated medical science. This technology contains the promise that both gene therapy and eugenic control of human evolution is possible, even plausible, in our near future. This book looks at these developements in the context of the history of previous social and scientific attempts at genetic editing, and explores the policy and ethical challenges they raise. It presents the case for altering the human germ-line (which contains and controls hereditary genetic information) to eliminate a large number of genetic diseases controlled by a single or few genes, while pointing out that gene therapy is likely to be ineffective for diseases with more complex causes. In parallel it explores the possibility of genetic enhancement in a set of case studies. But it also argues that, in general, genetic enhancement is ethically problematic and should be approached with caution. Given the success of CRISPR/Cas9 gene editing, and the explosion of related techniques, in practice it would be virtually impossible to ban germ-line editing in our future. A more useful goal is to put regulation in place, with oversight that represents the interests of society. That, in turn, requires an informed public discussion of these issues, which is the intention of this book.
Produktinformation
  • Utgivningsdatum: 2021-09-15
  • Mått: 162 x 238 x 18 mm
  • Vikt: 449 g
  • Format: Inbunden
  • Språk: Engelska
  • Antal sidor: 224
  • Förlag: Bloomsbury Publishing PLC
  • ISBN: 9781786614377
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Sahotra Sarkar is professor in the Departments of Philosophy and Integrative Biology at the University of Texas, Austin. He has taught at Boston and McGill Universities and held fellowships at MIT and the Max Planck Institute. He grew up in Darjeeling, India and was educated at Columbia University and the University of Chicago. He is a prolific author, social activist, and environmentalist working at the intersection of biology and society primarily in the American Southwest and in Mexico. A specialist in the history and philosophy of science, he has particular interest in both the philosophy of biology and physics.

Recensioner i media

The molecular gene-editing tool known as CRISPR—named for the DNA sequences it exploits (clustered regularly interspaced short palindromic repeats)—is poised to inspire a new era of eugenic thought and activity. Though the promise of eliminating genetic disorders has been discussed for decades in the context of gene therapy and the Human Genome Project, CRISPR technology has the potential to fulfill such promise. Sarkar's book, a thoughtful, fascinating exploration of this technology as it could enable pursuit of eugenics principles, will help readers frame and discuss the legal, social, and ethical challenges of CRISPR technology as it comes into more widespread use. Exhaustive notes and references round out a highly readable and useful book. Highly recommended. Lower- and upper-division undergraduates. Graduate students, faculty, and professionals. Students in two-year technical programs.

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