Animal Models for Endometriosis

Dr. Sharpe-Timms received her Ph.D. in Reproductive Pathophysiology from the University of Tennessee and completed a postdoctoral fellowship at the University of Kentucky. She served at the Department of Obstetrics, Gynecology and Women’s Health at the University of Missouri (MU) for over 30 years, advancing to Full Professor. Her research has identified proteins synthesized and secreted by endometriotic lesions, first in a rat model and later reproducing these results in women with endometriosis. She has also identified transgenerational subfertility in three generations of offspring using a rat model for endometriosis. Primarily funded by the National Institutes of Health, Dr. Sharpe-Timms’ endometriosis research has led to over 185 publications, abstracts, and invited oral presentations at national and international meetings. She retired from MU in 2019, now serving as Professor Emerita and collaborating with colleagues.

• Chapter 1. Introduction.- Chapter 2. Baboon model.- Chapter 3. Mechanisms of endometriosis-associated subfertility and novel therapeutic approaches discovered using a rat model.- Chapter 4. Animal models for pain or inflammation in endometriosis.- Chapter 5 Environmental endocrine disruptors and risk of endometriosis in mouse models.-Chapter 6. Deciphering the role of miRNAs in endometriosis pathophysiology using experimental endometriosis mouse models.- Chapter 7.Summation and future needs.