Advances in Anatomy, Embryology and Cell Biology – serie

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275 produkter

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275 produkter

Del 230 - Advances in Anatomy, Embryology and Cell Biology
Origin of a New Progenitor Stem Cell Group in Human Development
An Immunohistochemical-, Light- and Electronmicroscopical Analysis
AvHubert Wartenberg,Andreas Miethingm. fl.
Häftad, Engelska, 2019
1 139 kr
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This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs. The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets. These newly detected stem cells represent a specific developmental step which is found only in humans.
Del 231 - Advances in Anatomy, Embryology and Cell Biology
Cellular and Molecular Basis of Mitochondrial Inheritance
Mitochondrial Disease and Fitness
AvPeter Sutovsky
Häftad, Engelska, 2019
1 252 kr
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
Del 232 - Advances in Anatomy, Embryology and Cell Biology
Animal Models for Endometriosis
Evolution, Utility and Clinical Relevance
AvKathy L. Sharpe-Timms
Häftad, Engelska, 2020
1 252 kr
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility.Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models. The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.
Del 233 - Advances in Anatomy, Embryology and Cell Biology
Pulmonary Neuroepithelial Body Microenvironment
A Multifunctional Unit in the Airway Epithelium
AvInge Brouns,Line Verckistm. fl.
Häftad, Engelska, 2021
1 252 kr
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This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis.Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease.This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors
Del 234 - Advances in Anatomy, Embryology and Cell Biology
Placentation in Mammals
Tribute to E.C. Amoroso’s Lifetime Contributions to Viviparity
AvRodney D. Geisert,Thomas Spencer
Häftad, Engelska, 2021
1 479 kr
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The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta’ protects the fetus from maternal immune rejection and provides oxygen and nutrient flow to support it to term across all the species, structural differentiation of this fetal-maternal interface can vary from simple to very complex. E.C. Amoroso contributed greatly to our early understanding and knowledge of placentation across a great variety ofspecies. His work on placentation provides numerous illustrations and histological sections which are used for teaching and stimulating research today. With this book, we want to pay tribute to his lifetime contributions to the field by reviewing our current understanding of the development of viviparity and placentation in different species. The book is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in placentation and viviparity.
Del 235 - Advances in Anatomy, Embryology and Cell Biology
Centrosome and its Functions and Dysfunctions
AvHeide Schatten
Häftad, Engelska, 2022
969 kr
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The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders.This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
Del 236 - Advances in Anatomy, Embryology and Cell Biology
Roles of Skeletal Muscle in Organ Development
Prenatal Interdependence among Cells, Tissues, and Organs
AvBoris Kablar
Häftad, Engelska, 2023
1 479 kr
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Muscle is the only tissue of the four basic types that make the body that can be completely ablated while allowing fetal survival. This book is a result of 25 years of research employing engineered mouse fetuses with no skeletal muscle, a model system that provides a unique opportunity to study body development holistically.A systematic anatomical analysis of such fetuses have shown that several anatomical locations are affected by the absence of the skeletal muscle. This book contains a summarized description of affected anatomical locations such as the alveolar lung epithelium, motor neurons and giant pyramidal cells in the CNS, cholinergic amacrine cells of the retina, and type I hair cells of the crista ampullaris. Several specific bioinformatics and systems biology interventions are also described. The book provides an update on skeletal muscle development, musculoskeletal developmental interactions, trophic relationships between the skeletal muscle and the motor neurons, mechanics of lung development, functional development of two special senses, eye and ear, and finally, skeletal muscle-related reasons for human fetal akinesia and its consequences.This volume in the Advances in Anatomy, Embryology and Cell Biology series stresses the need to think about the developing body and its organs in terms of their mutual interdependence, and to think about diseases, such as pulmonary hypoplasia, amyotrophic lateral sclerosis, or cleft palate, in terms of that interdependence. Directed to developmental biologists, neuroscientists, tissue engineers and health professionals, this book exposes the ideas of interorgan communication and interdependence in homeostasis and disease.
Del 237 - Advances in Anatomy, Embryology and Cell Biology
Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body
AvNikolai E. Lazarov,Dimitrinka Y. Atanasova
Häftad, Engelska, 2023
1 139 kr
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This new volume of the book series Advances in Anatomy, Embryology and Cell Biology provides a complete and exhaustive overview of the morphofunctional organization of the mammalian carotid body, a polymodal chemosensory organ responsible for the maintenance of blood gas homeostasis. The authors review the state of the art of the neurochemical anatomy of carotid body´s cell populations with a special reference to their structural and neurochemical plasticity. The essential role of this organ in the generation, progression and maintenance of cardiorespiratory and metabolic diseases in humans and other mammals is presented. Finally, the book summarizes current knowledge on the stem cell niche in the mammalian carotid body and discusses its contribution to replacement cell therapy and other potential applications in translational research. This book represents an essential reading for physiologists, anatomists, cell, and developmental biologists, as wellas physicians, veterinarians, and biomedical researchers.
Del 238 - Advances in Anatomy, Embryology and Cell Biology
Molecular Mechanisms Determining Mammalian Oocyte Quality
Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance
AvAhmed Z. Balboula
Häftad, Engelska, 2024
1 479 kr
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As the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms.Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes.This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis.
Del 239 - Advances in Anatomy, Embryology and Cell Biology
Molecular and Cell Biology of Pancreas Development, Function and Regeneration
AvMaria L. Golson
Häftad, Engelska, 2024
1 592 kr
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This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis.The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.
Del 240 - Advances in Anatomy, Embryology and Cell Biology
Abnormal Morphology of Bovine Spermatozoa
AvAlbert Barth,Viv E. A. Perrym. fl.
Häftad, Engelska, 2025
1 592 kr
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This book provides a broad perspective on understanding bovine fertility, focusing on the classification and interpretation of bovine sperm defects.Building upon the success of its first edition published in 1989, this new edition has been significantly updated and expanded to reflect developments over the past three decades. The chapters cover topics such as the normal and abnormal development of bovine sperm, the mechanisms behind sperm defects, and the impact of these defects on fertility. Special attention is drawn at advances in genomic research and the use of sperm quality biomarkers and genetic screening tests in the assessment of bull fertility. In addition to this, the work explores critical periods for sexual development in bulls, such as early gestation and pre-weaning.This monograph is intended for researchers and students in the field of animal reproduction, veterinarians, and animal scientists. It provides a deep understanding of bovine fertility, a topic that is crucial for anyone working in livestock production or related fields. The knowledge gained from this book will be beneficial to those seeking to improve livestock productivity and thus contribute to global food security.
Del 241 - Advances in Anatomy, Embryology and Cell Biology
Extracellular Vesicles in Reproduction
Origin, Functions and Perspective
AvPei-Shiue Tsai
Häftad, Engelska, 2026
1 252 kr
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This book reviews the role of exosomes in both male and female reproduction organs, focusing on the impact of extracellular vesicles on gamete maturation and embryo development.Fertilization is a complex process involving the fusion of two functionally matured gametes. Maturation of spermatozoa and/ or oocyte dependents on sophisticated, but highly regulated events during gamete transit in the reproductive tracts. Sperm maturation occurs within the epididymis, of which segmented regions provide a distinct microenvironment to facilitate stage-wise maturation processes. Although oocyte maturation occurs within the ovary, communication between oocyte and its surrounding granulosa/cumulus cells is vital for the development and the resumption of meiotically arrested oocytes. Once the oocyte is released from the ovary, the oviductal epithelium continues to facilitate sperm-oocyte interaction to achieve fertilization. Increasing evidence suggests that the uterus, the site for embryo development, also carries out epithelia- embryo communication via uterosomes throughout the pregnancy. All above-mentioned processes rely on orchestrated communications between reproductive tract epithelia and gametes.In this book, we aim to summarize the origin of secretory vesicles from the reproductive tract and their functions for gamete and embryo development. It is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in extracellular vesicles research.
Del 242 - Advances in Anatomy, Embryology and Cell Biology
Rise of Anatomical Study in Medicine and Surgery
The Informed Body
AvAndreas K. Demetriades,Hilary S. Morrism. fl.
Häftad, Engelska, 2026
1 479 kr
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Across centuries, the study of human anatomy has stood at the intersection of science, ethics, and culture. This volume offers a critical synthesis of how anatomical knowledge has been pursued, contested, and transformed from Renaissance dissection theatres to today’s virtual reality labs. It examines anatomy not merely as a technical discipline but as a cultural artefact—shaped by artistic representation, political power, and evolving pedagogical norms.Contributors trace the ethical dilemmas of cadaveric dissection, the artistry of wax modelling and medical illustration, and the disruptive potential of digital and AI-driven tools. Case studies explore Vesalius’ revolutionary methods, the illicit economies of 19th-century body procurement, and the colonial legacies embedded in anatomical collections. Contemporary chapters interrogate gender bias in medical imaging, the rise of ultrasound and plastination, and the challenges of decolonising curricula.Bringing together historians, clinicians, educators, and ethicists, this interdisciplinary work situates anatomy within broader debates on professional identity, social justice, and technological innovation. It argues that understanding anatomy’s past—its exclusions, exploitations, and epistemic struggles—is essential for shaping an ethical and inclusive future in medical education.Ideal for scholars and practitioners in history of medicine, medical ethics, surgical education, and cultural studies, this book provides a nuanced framework for rethinking anatomy as both scientific practice and social institution.
Del 215 - Advances in Anatomy, Embryology and Cell Biology
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
AvHeiko Braak,Kelly Del Tredici
Häftad, Engelska, 2014
1 818 kr
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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
Del 216 - Advances in Anatomy, Embryology and Cell Biology
Regulation of Implantation and Establishment of Pregnancy in Mammals
Tribute to 45 Year Anniversary of Roger V. Short's "Maternal Recognition of Pregnancy"
AvRodney D. Geisert,Fuller W. Bazer
Häftad, Engelska, 2015
1 139 kr
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Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.
Del 217 - Advances in Anatomy, Embryology and Cell Biology
Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
AvUdo Rüb,Jean Paul G. Vonsattelm. fl.
Häftad, Engelska, 2015
1 139 kr
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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
Del 218 - Advances in Anatomy, Embryology and Cell Biology
Metallothioneins in Normal and Cancer Cells
AvPiotr Dziegiel,Bartosz Pulam. fl.
Häftad, Engelska, 2016
573 kr
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This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
Del 219 - Advances in Anatomy, Embryology and Cell Biology
Focus on Bio-Image Informatics
AvWinnok H. De Vos,Sebastian Munckm. fl.
Häftad, Engelska, 2016
1 106 kr
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This volume of Advances Anatomy Embryology and Cell Biology focuses on the emerging field of bio-image informatics, presenting novel and exciting ways of handling and interpreting large image data sets. A collection of focused reviews written by key players in the field highlights the major directions and provides an excellent reference work for both young and experienced researchers.
Del 220 - Advances in Anatomy, Embryology and Cell Biology
Sperm Acrosome Biogenesis and Function During Fertilization
AvMariano G. Buffone
Häftad, Engelska, 2016
1 139 kr
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Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reportedin neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
Disordered Vertebral and Rib Morphology in Pudgy Mice
Structural Relationships to Human Congenital Scoliosis
AvFrederic Shapiro
Häftad, Engelska, 2016
1 139 kr
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This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
Del 222 - Advances in Anatomy, Embryology and Cell Biology
Role of Heat Shock Proteins in Reproductive System Development and Function
AvDaniel J. MacPhee
Häftad, Engelska, 2017
1 592 kr
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Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.
Del 224 - Advances in Anatomy, Embryology and Cell Biology
Translational Anatomy and Cell Biology of Autism Spectrum Disorder
AvMichael J. Schmeisser,Tobias M. Boeckers
Häftad, Engelska, 2017
1 592 kr
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Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
Del 223 - Advances in Anatomy, Embryology and Cell Biology
Cell Biology of Herpes Viruses
AvKlaus Osterrieder
Häftad, Engelska, 2017
1 705 kr
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Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences inthe establishment and maintenance of virus persistence will be covered.
Del 227 - Advances in Anatomy, Embryology and Cell Biology
Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy
AvJulita Kulbacka,Saulius Satkauskas
Häftad, Engelska, 2017
1 592 kr
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This book elucidates the mechanisms involved in biological membrane functions.It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics.The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).
Del 226 - Advances in Anatomy, Embryology and Cell Biology
Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia
AvEnnio Pannese
Häftad, Engelska, 2018
1 252 kr
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This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. For a long time since their discovery by Valentin in the first half of the 19th century these cells received only modest attention. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment. Thus, interest in satellite cells has burgeoned. The review is based on the author’s own work as well as on his critical evaluation and systematic arrangement of data scattered through a large number of research papers. The following aspects of perineuronal satellite cells are covered: Shape and structure; molecular characteristics; origin and development; biological and functional properties; relationships with the ganglion sensory neuron; age-related changes; roles under physiological conditions; reactions to experimental and pathological conditions; role in neuropathic pain.
Del 229 - Advances in Anatomy, Embryology and Cell Biology
Chromatin Regulation of Early Embryonic Lineage Specification
AvJason Knott,Keith Latham
Häftad, Engelska, 2017
1 365 kr
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Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
Molecular and Functional Insights Into the Pulmonary Vasculature
AvKaushik Parthasarathi
Häftad, Engelska, 2018
1 252 kr
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This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
Pulvinar Thalamic Nucleus of Non-Human Primates: Architectonic and Functional Subdivisions
AvRicardo Gattass,Juliana G.M. Soaresm. fl.
Häftad, Engelska, 2017
1 216 kr
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This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional and behavioral requirements of each species.The pulvinar, the largest nucleus of the primate thalamus, has extensive and reciprocal connections with several areas of the neocortex. These input-output loops suggest that the pulvinar may regulate the flow of information within and between cortical areas in a highly dynamic fashion. Therefore, understanding the anatomical subdivisions within the pulvinar, and its connectivity with the cortex, is paramount to understanding pulvinar physiological function. However, there is a stark contrast regarding the way that the pulvinar is subdivided depending on the technique employed. Cytoarchitectural and immunohistochemical methods reveal a very similar pattern of pulvinar subdivision across Old- and New-World monkeys. On the other hand, electrophysiological and connectivity studies expose clear discrepancies in pulvinar organization across primate evolution.
Del 169 - Advances in Anatomy, Embryology and Cell Biology
Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head
AvPhilippa H. Francis-West,Lesley Robsonm. fl.
Häftad, Engelska, 2003
1 139 kr
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Craniofacial development is a multistep and intricate process initially involving a number of inductive interactions that control neural and neural crest development, which are followed by a series of epithelial-mesenchymal interactions that control outgrowth, patterning, and skeletal differentiation. Certain aspects of craniofacial development are unique developmental processes in higher vertebrates. First, in higher vertebrates the cranial neural crest, in contrast to the trunk neural crest, gives rise to the skeletal structures. These skeletal elements include those comprising mem brane bone and secondary cartilage, which with the exception of the clavicle are tissue types found exclusively in the head in higher vertebrates. Second, with the exception of the tongue, the origin of the musculature is distinct from other regions of the body. The body and tongue muscles are formed from the segmented epithelial somites whilst the head musculature is formed from unsegmented paraxial and prechordal mesoderm. Furthermore, the signalling cascades that control myogenic differentia tion appear to be distinct as determined by gene expression and the response of myogenic cells to growth factors. Finally, the neurogenic placodes, which give rise to the sensory organs and some cranial ganglia, are only found in the head. Over recent years, there have been significant advances in our knowledge of the molecular proc esses that control craniofacial development in a number of animal models. This has given insight into the genes that control many aspects of head development from the initial induction of the head to the final stages of differentiation.
Del 172 - Advances in Anatomy, Embryology and Cell Biology
Sensory Circumventricular Organs of the Mammalian Brain
Subfornical Organ, OVLT and Area Postrema
AvMichael J. McKinley,Robin M. McAllenm. fl.
Häftad, Engelska, 2003
1 139 kr
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This is the only book entirely devoted to the sensory circumventricular organs. It reviews research into their detailed anatomy, neurochemistry, neural connections, and functions, and provides the reader with many illustrations previously unpublished.

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275 produkter

Del 230 - Advances in Anatomy, Embryology and Cell Biology
Origin of a New Progenitor Stem Cell Group in Human Development
An Immunohistochemical-, Light- and Electronmicroscopical Analysis
AvHubert Wartenberg,Andreas Miethingm. fl.
Häftad, Engelska, 2019
1 139 kr
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This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs. The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets. These newly detected stem cells represent a specific developmental step which is found only in humans.
Del 231 - Advances in Anatomy, Embryology and Cell Biology
Cellular and Molecular Basis of Mitochondrial Inheritance
Mitochondrial Disease and Fitness
AvPeter Sutovsky
Häftad, Engelska, 2019
1 252 kr
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.
Del 232 - Advances in Anatomy, Embryology and Cell Biology
Animal Models for Endometriosis
Evolution, Utility and Clinical Relevance
AvKathy L. Sharpe-Timms
Häftad, Engelska, 2020
1 252 kr
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility.Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models. The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.
Del 233 - Advances in Anatomy, Embryology and Cell Biology
Pulmonary Neuroepithelial Body Microenvironment
A Multifunctional Unit in the Airway Epithelium
AvInge Brouns,Line Verckistm. fl.
Häftad, Engelska, 2021
1 252 kr
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This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis.Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease.This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors
Del 234 - Advances in Anatomy, Embryology and Cell Biology
Placentation in Mammals
Tribute to E.C. Amoroso’s Lifetime Contributions to Viviparity
AvRodney D. Geisert,Thomas Spencer
Häftad, Engelska, 2021
1 479 kr
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The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta’ protects the fetus from maternal immune rejection and provides oxygen and nutrient flow to support it to term across all the species, structural differentiation of this fetal-maternal interface can vary from simple to very complex. E.C. Amoroso contributed greatly to our early understanding and knowledge of placentation across a great variety ofspecies. His work on placentation provides numerous illustrations and histological sections which are used for teaching and stimulating research today. With this book, we want to pay tribute to his lifetime contributions to the field by reviewing our current understanding of the development of viviparity and placentation in different species. The book is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in placentation and viviparity.
Del 235 - Advances in Anatomy, Embryology and Cell Biology
Centrosome and its Functions and Dysfunctions
AvHeide Schatten
Häftad, Engelska, 2022
969 kr
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The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders.This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
Del 236 - Advances in Anatomy, Embryology and Cell Biology
Roles of Skeletal Muscle in Organ Development
Prenatal Interdependence among Cells, Tissues, and Organs
AvBoris Kablar
Häftad, Engelska, 2023
1 479 kr
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Muscle is the only tissue of the four basic types that make the body that can be completely ablated while allowing fetal survival. This book is a result of 25 years of research employing engineered mouse fetuses with no skeletal muscle, a model system that provides a unique opportunity to study body development holistically.A systematic anatomical analysis of such fetuses have shown that several anatomical locations are affected by the absence of the skeletal muscle. This book contains a summarized description of affected anatomical locations such as the alveolar lung epithelium, motor neurons and giant pyramidal cells in the CNS, cholinergic amacrine cells of the retina, and type I hair cells of the crista ampullaris. Several specific bioinformatics and systems biology interventions are also described. The book provides an update on skeletal muscle development, musculoskeletal developmental interactions, trophic relationships between the skeletal muscle and the motor neurons, mechanics of lung development, functional development of two special senses, eye and ear, and finally, skeletal muscle-related reasons for human fetal akinesia and its consequences.This volume in the Advances in Anatomy, Embryology and Cell Biology series stresses the need to think about the developing body and its organs in terms of their mutual interdependence, and to think about diseases, such as pulmonary hypoplasia, amyotrophic lateral sclerosis, or cleft palate, in terms of that interdependence. Directed to developmental biologists, neuroscientists, tissue engineers and health professionals, this book exposes the ideas of interorgan communication and interdependence in homeostasis and disease.
Del 237 - Advances in Anatomy, Embryology and Cell Biology
Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body
AvNikolai E. Lazarov,Dimitrinka Y. Atanasova
Häftad, Engelska, 2023
1 139 kr
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This new volume of the book series Advances in Anatomy, Embryology and Cell Biology provides a complete and exhaustive overview of the morphofunctional organization of the mammalian carotid body, a polymodal chemosensory organ responsible for the maintenance of blood gas homeostasis. The authors review the state of the art of the neurochemical anatomy of carotid body´s cell populations with a special reference to their structural and neurochemical plasticity. The essential role of this organ in the generation, progression and maintenance of cardiorespiratory and metabolic diseases in humans and other mammals is presented. Finally, the book summarizes current knowledge on the stem cell niche in the mammalian carotid body and discusses its contribution to replacement cell therapy and other potential applications in translational research. This book represents an essential reading for physiologists, anatomists, cell, and developmental biologists, as wellas physicians, veterinarians, and biomedical researchers.
Del 238 - Advances in Anatomy, Embryology and Cell Biology
Molecular Mechanisms Determining Mammalian Oocyte Quality
Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance
AvAhmed Z. Balboula
Häftad, Engelska, 2024
1 479 kr
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As the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms.Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes.This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis.
Del 239 - Advances in Anatomy, Embryology and Cell Biology
Molecular and Cell Biology of Pancreas Development, Function and Regeneration
AvMaria L. Golson
Häftad, Engelska, 2024
1 592 kr
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This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis.The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.
Del 240 - Advances in Anatomy, Embryology and Cell Biology
Abnormal Morphology of Bovine Spermatozoa
AvAlbert Barth,Viv E. A. Perrym. fl.
Häftad, Engelska, 2025
1 592 kr
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This book provides a broad perspective on understanding bovine fertility, focusing on the classification and interpretation of bovine sperm defects.Building upon the success of its first edition published in 1989, this new edition has been significantly updated and expanded to reflect developments over the past three decades. The chapters cover topics such as the normal and abnormal development of bovine sperm, the mechanisms behind sperm defects, and the impact of these defects on fertility. Special attention is drawn at advances in genomic research and the use of sperm quality biomarkers and genetic screening tests in the assessment of bull fertility. In addition to this, the work explores critical periods for sexual development in bulls, such as early gestation and pre-weaning.This monograph is intended for researchers and students in the field of animal reproduction, veterinarians, and animal scientists. It provides a deep understanding of bovine fertility, a topic that is crucial for anyone working in livestock production or related fields. The knowledge gained from this book will be beneficial to those seeking to improve livestock productivity and thus contribute to global food security.
Del 241 - Advances in Anatomy, Embryology and Cell Biology
Extracellular Vesicles in Reproduction
Origin, Functions and Perspective
AvPei-Shiue Tsai
Häftad, Engelska, 2026
1 252 kr
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This book reviews the role of exosomes in both male and female reproduction organs, focusing on the impact of extracellular vesicles on gamete maturation and embryo development.Fertilization is a complex process involving the fusion of two functionally matured gametes. Maturation of spermatozoa and/ or oocyte dependents on sophisticated, but highly regulated events during gamete transit in the reproductive tracts. Sperm maturation occurs within the epididymis, of which segmented regions provide a distinct microenvironment to facilitate stage-wise maturation processes. Although oocyte maturation occurs within the ovary, communication between oocyte and its surrounding granulosa/cumulus cells is vital for the development and the resumption of meiotically arrested oocytes. Once the oocyte is released from the ovary, the oviductal epithelium continues to facilitate sperm-oocyte interaction to achieve fertilization. Increasing evidence suggests that the uterus, the site for embryo development, also carries out epithelia- embryo communication via uterosomes throughout the pregnancy. All above-mentioned processes rely on orchestrated communications between reproductive tract epithelia and gametes.In this book, we aim to summarize the origin of secretory vesicles from the reproductive tract and their functions for gamete and embryo development. It is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in extracellular vesicles research.
Del 242 - Advances in Anatomy, Embryology and Cell Biology
Rise of Anatomical Study in Medicine and Surgery
The Informed Body
AvAndreas K. Demetriades,Hilary S. Morrism. fl.
Häftad, Engelska, 2026
1 479 kr
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Across centuries, the study of human anatomy has stood at the intersection of science, ethics, and culture. This volume offers a critical synthesis of how anatomical knowledge has been pursued, contested, and transformed from Renaissance dissection theatres to today’s virtual reality labs. It examines anatomy not merely as a technical discipline but as a cultural artefact—shaped by artistic representation, political power, and evolving pedagogical norms.Contributors trace the ethical dilemmas of cadaveric dissection, the artistry of wax modelling and medical illustration, and the disruptive potential of digital and AI-driven tools. Case studies explore Vesalius’ revolutionary methods, the illicit economies of 19th-century body procurement, and the colonial legacies embedded in anatomical collections. Contemporary chapters interrogate gender bias in medical imaging, the rise of ultrasound and plastination, and the challenges of decolonising curricula.Bringing together historians, clinicians, educators, and ethicists, this interdisciplinary work situates anatomy within broader debates on professional identity, social justice, and technological innovation. It argues that understanding anatomy’s past—its exclusions, exploitations, and epistemic struggles—is essential for shaping an ethical and inclusive future in medical education.Ideal for scholars and practitioners in history of medicine, medical ethics, surgical education, and cultural studies, this book provides a nuanced framework for rethinking anatomy as both scientific practice and social institution.
Del 215 - Advances in Anatomy, Embryology and Cell Biology
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
AvHeiko Braak,Kelly Del Tredici
Häftad, Engelska, 2014
1 818 kr
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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
Del 216 - Advances in Anatomy, Embryology and Cell Biology
Regulation of Implantation and Establishment of Pregnancy in Mammals
Tribute to 45 Year Anniversary of Roger V. Short's "Maternal Recognition of Pregnancy"
AvRodney D. Geisert,Fuller W. Bazer
Häftad, Engelska, 2015
1 139 kr
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Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.
Del 217 - Advances in Anatomy, Embryology and Cell Biology
Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
AvUdo Rüb,Jean Paul G. Vonsattelm. fl.
Häftad, Engelska, 2015
1 139 kr
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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
Del 218 - Advances in Anatomy, Embryology and Cell Biology
Metallothioneins in Normal and Cancer Cells
AvPiotr Dziegiel,Bartosz Pulam. fl.
Häftad, Engelska, 2016
573 kr
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This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
Del 219 - Advances in Anatomy, Embryology and Cell Biology
Focus on Bio-Image Informatics
AvWinnok H. De Vos,Sebastian Munckm. fl.
Häftad, Engelska, 2016
1 106 kr
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This volume of Advances Anatomy Embryology and Cell Biology focuses on the emerging field of bio-image informatics, presenting novel and exciting ways of handling and interpreting large image data sets. A collection of focused reviews written by key players in the field highlights the major directions and provides an excellent reference work for both young and experienced researchers.
Del 220 - Advances in Anatomy, Embryology and Cell Biology
Sperm Acrosome Biogenesis and Function During Fertilization
AvMariano G. Buffone
Häftad, Engelska, 2016
1 139 kr
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Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reportedin neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
Disordered Vertebral and Rib Morphology in Pudgy Mice
Structural Relationships to Human Congenital Scoliosis
AvFrederic Shapiro
Häftad, Engelska, 2016
1 139 kr
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This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
Del 222 - Advances in Anatomy, Embryology and Cell Biology
Role of Heat Shock Proteins in Reproductive System Development and Function
AvDaniel J. MacPhee
Häftad, Engelska, 2017
1 592 kr
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Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.
Del 224 - Advances in Anatomy, Embryology and Cell Biology
Translational Anatomy and Cell Biology of Autism Spectrum Disorder
AvMichael J. Schmeisser,Tobias M. Boeckers
Häftad, Engelska, 2017
1 592 kr
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Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
Del 223 - Advances in Anatomy, Embryology and Cell Biology
Cell Biology of Herpes Viruses
AvKlaus Osterrieder
Häftad, Engelska, 2017
1 705 kr
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Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences inthe establishment and maintenance of virus persistence will be covered.
Del 227 - Advances in Anatomy, Embryology and Cell Biology
Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy
AvJulita Kulbacka,Saulius Satkauskas
Häftad, Engelska, 2017
1 592 kr
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This book elucidates the mechanisms involved in biological membrane functions.It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics.The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).
Del 226 - Advances in Anatomy, Embryology and Cell Biology
Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia
AvEnnio Pannese
Häftad, Engelska, 2018
1 252 kr
Skickas inom 10-15 vardagar
This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. For a long time since their discovery by Valentin in the first half of the 19th century these cells received only modest attention. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment. Thus, interest in satellite cells has burgeoned. The review is based on the author’s own work as well as on his critical evaluation and systematic arrangement of data scattered through a large number of research papers. The following aspects of perineuronal satellite cells are covered: Shape and structure; molecular characteristics; origin and development; biological and functional properties; relationships with the ganglion sensory neuron; age-related changes; roles under physiological conditions; reactions to experimental and pathological conditions; role in neuropathic pain.
Del 229 - Advances in Anatomy, Embryology and Cell Biology
Chromatin Regulation of Early Embryonic Lineage Specification
AvJason Knott,Keith Latham
Häftad, Engelska, 2017
1 365 kr
Skickas inom 10-15 vardagar
Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
Molecular and Functional Insights Into the Pulmonary Vasculature
AvKaushik Parthasarathi
Häftad, Engelska, 2018
1 252 kr
Skickas inom 10-15 vardagar
This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
Pulvinar Thalamic Nucleus of Non-Human Primates: Architectonic and Functional Subdivisions
AvRicardo Gattass,Juliana G.M. Soaresm. fl.
Häftad, Engelska, 2017
1 216 kr
Skickas inom 10-15 vardagar
This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional and behavioral requirements of each species.The pulvinar, the largest nucleus of the primate thalamus, has extensive and reciprocal connections with several areas of the neocortex. These input-output loops suggest that the pulvinar may regulate the flow of information within and between cortical areas in a highly dynamic fashion. Therefore, understanding the anatomical subdivisions within the pulvinar, and its connectivity with the cortex, is paramount to understanding pulvinar physiological function. However, there is a stark contrast regarding the way that the pulvinar is subdivided depending on the technique employed. Cytoarchitectural and immunohistochemical methods reveal a very similar pattern of pulvinar subdivision across Old- and New-World monkeys. On the other hand, electrophysiological and connectivity studies expose clear discrepancies in pulvinar organization across primate evolution.
Del 169 - Advances in Anatomy, Embryology and Cell Biology
Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head
AvPhilippa H. Francis-West,Lesley Robsonm. fl.
Häftad, Engelska, 2003
1 139 kr
Skickas inom 10-15 vardagar
Craniofacial development is a multistep and intricate process initially involving a number of inductive interactions that control neural and neural crest development, which are followed by a series of epithelial-mesenchymal interactions that control outgrowth, patterning, and skeletal differentiation. Certain aspects of craniofacial development are unique developmental processes in higher vertebrates. First, in higher vertebrates the cranial neural crest, in contrast to the trunk neural crest, gives rise to the skeletal structures. These skeletal elements include those comprising mem brane bone and secondary cartilage, which with the exception of the clavicle are tissue types found exclusively in the head in higher vertebrates. Second, with the exception of the tongue, the origin of the musculature is distinct from other regions of the body. The body and tongue muscles are formed from the segmented epithelial somites whilst the head musculature is formed from unsegmented paraxial and prechordal mesoderm. Furthermore, the signalling cascades that control myogenic differentia tion appear to be distinct as determined by gene expression and the response of myogenic cells to growth factors. Finally, the neurogenic placodes, which give rise to the sensory organs and some cranial ganglia, are only found in the head. Over recent years, there have been significant advances in our knowledge of the molecular proc esses that control craniofacial development in a number of animal models. This has given insight into the genes that control many aspects of head development from the initial induction of the head to the final stages of differentiation.
Del 172 - Advances in Anatomy, Embryology and Cell Biology
Sensory Circumventricular Organs of the Mammalian Brain
Subfornical Organ, OVLT and Area Postrema
AvMichael J. McKinley,Robin M. McAllenm. fl.
Häftad, Engelska, 2003
1 139 kr
Skickas inom 10-15 vardagar
This is the only book entirely devoted to the sensory circumventricular organs. It reviews research into their detailed anatomy, neurochemistry, neural connections, and functions, and provides the reader with many illustrations previously unpublished.

Advances in Anatomy, Embryology and Cell Biology – serie

Origin of a New Progenitor Stem Cell Group in Human Development

Cellular and Molecular Basis of Mitochondrial Inheritance

Animal Models for Endometriosis

Pulmonary Neuroepithelial Body Microenvironment

Placentation in Mammals

Centrosome and its Functions and Dysfunctions

Roles of Skeletal Muscle in Organ Development

Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body

Molecular Mechanisms Determining Mammalian Oocyte Quality

Molecular and Cell Biology of Pancreas Development, Function and Regeneration

Abnormal Morphology of Bovine Spermatozoa

Extracellular Vesicles in Reproduction

Rise of Anatomical Study in Medicine and Surgery

Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

Regulation of Implantation and Establishment of Pregnancy in Mammals

Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

Metallothioneins in Normal and Cancer Cells

Focus on Bio-Image Informatics

Sperm Acrosome Biogenesis and Function During Fertilization

Disordered Vertebral and Rib Morphology in Pudgy Mice

Role of Heat Shock Proteins in Reproductive System Development and Function

Translational Anatomy and Cell Biology of Autism Spectrum Disorder

Cell Biology of Herpes Viruses

Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy

Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia

Chromatin Regulation of Early Embryonic Lineage Specification

Molecular and Functional Insights Into the Pulmonary Vasculature

Pulvinar Thalamic Nucleus of Non-Human Primates: Architectonic and Functional Subdivisions

Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head

Sensory Circumventricular Organs of the Mammalian Brain

Advances in Anatomy, Embryology and Cell Biology – serie

Origin of a New Progenitor Stem Cell Group in Human Development

Cellular and Molecular Basis of Mitochondrial Inheritance

Animal Models for Endometriosis

Pulmonary Neuroepithelial Body Microenvironment

Placentation in Mammals

Centrosome and its Functions and Dysfunctions

Roles of Skeletal Muscle in Organ Development

Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body

Molecular Mechanisms Determining Mammalian Oocyte Quality

Molecular and Cell Biology of Pancreas Development, Function and Regeneration

Abnormal Morphology of Bovine Spermatozoa

Extracellular Vesicles in Reproduction

Rise of Anatomical Study in Medicine and Surgery

Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

Regulation of Implantation and Establishment of Pregnancy in Mammals

Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

Metallothioneins in Normal and Cancer Cells

Focus on Bio-Image Informatics

Sperm Acrosome Biogenesis and Function During Fertilization

Disordered Vertebral and Rib Morphology in Pudgy Mice

Role of Heat Shock Proteins in Reproductive System Development and Function

Translational Anatomy and Cell Biology of Autism Spectrum Disorder

Cell Biology of Herpes Viruses

Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy

Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia

Chromatin Regulation of Early Embryonic Lineage Specification

Molecular and Functional Insights Into the Pulmonary Vasculature

Pulvinar Thalamic Nucleus of Non-Human Primates: Architectonic and Functional Subdivisions

Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head

Sensory Circumventricular Organs of the Mammalian Brain