Advances in Anatomy, Embryology and Cell Biology – serie
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275 produkter
275 produkter
Del 230 - Advances in Anatomy, Embryology and Cell Biology
Origin of a New Progenitor Stem Cell Group in Human Development
An Immunohistochemical-, Light- and Electronmicroscopical Analysis
Häftad, Engelska, 2019
1 114 kr
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This book presents an overview of a new group of progenitor stem cells. From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues.
Del 231 - Advances in Anatomy, Embryology and Cell Biology
Cellular and Molecular Basis of Mitochondrial Inheritance
Mitochondrial Disease and Fitness
Häftad, Engelska, 2019
1 224 kr
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C.
Del 232 - Advances in Anatomy, Embryology and Cell Biology
Animal Models for Endometriosis
Evolution, Utility and Clinical Relevance
Häftad, Engelska, 2020
1 224 kr
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This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis.
Del 233 - Advances in Anatomy, Embryology and Cell Biology
Pulmonary Neuroepithelial Body Microenvironment
A Multifunctional Unit in the Airway Epithelium
Häftad, Engelska, 2021
1 224 kr
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This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis.Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease.This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors
Placentation in Mammals
Tribute to E.C. Amoroso’s Lifetime Contributions to Viviparity
Häftad, Engelska, 2021
1 446 kr
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The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy.
Del 235 - Advances in Anatomy, Embryology and Cell Biology
Centrosome and its Functions and Dysfunctions
Häftad, Engelska, 2022
948 kr
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The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases.
Del 236 - Advances in Anatomy, Embryology and Cell Biology
Roles of Skeletal Muscle in Organ Development
Prenatal Interdependence among Cells, Tissues, and Organs
Häftad, Engelska, 2023
1 446 kr
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Muscle is the only tissue of the four basic types that make the body that can be completely ablated while allowing fetal survival. This book is a result of 25 years of research employing engineered mouse fetuses with no skeletal muscle, a model system that provides a unique opportunity to study body development holistically.A systematic anatomical analysis of such fetuses have shown that several anatomical locations are affected by the absence of the skeletal muscle. This book contains a summarized description of affected anatomical locations such as the alveolar lung epithelium, motor neurons and giant pyramidal cells in the CNS, cholinergic amacrine cells of the retina, and type I hair cells of the crista ampullaris. Several specific bioinformatics and systems biology interventions are also described. The book provides an update on skeletal muscle development, musculoskeletal developmental interactions, trophic relationships between the skeletal muscle and the motor neurons, mechanics of lung development, functional development of two special senses, eye and ear, and finally, skeletal muscle-related reasons for human fetal akinesia and its consequences.This volume in the Advances in Anatomy, Embryology and Cell Biology series stresses the need to think about the developing body and its organs in terms of their mutual interdependence, and to think about diseases, such as pulmonary hypoplasia, amyotrophic lateral sclerosis, or cleft palate, in terms of that interdependence. Directed to developmental biologists, neuroscientists, tissue engineers and health professionals, this book exposes the ideas of interorgan communication and interdependence in homeostasis and disease.
Del 237 - Advances in Anatomy, Embryology and Cell Biology
Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body
Häftad, Engelska, 2023
1 114 kr
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This new volume of the book series Advances in Anatomy, Embryology and Cell Biology provides a complete and exhaustive overview of the morphofunctional organization of the mammalian carotid body, a polymodal chemosensory organ responsible for the maintenance of blood gas homeostasis.
Del 238 - Advances in Anatomy, Embryology and Cell Biology
Molecular Mechanisms Determining Mammalian Oocyte Quality
Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance
Häftad, Engelska, 2024
1 446 kr
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Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I.
Del 239 - Advances in Anatomy, Embryology and Cell Biology
Molecular and Cell Biology of Pancreas Development, Function and Regeneration
Häftad, Engelska, 2024
1 556 kr
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This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis.The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.
Del 240 - Advances in Anatomy, Embryology and Cell Biology
Abnormal Morphology of Bovine Spermatozoa
Häftad, Engelska, 2025
1 556 kr
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This book provides a broad perspective on understanding bovine fertility, focusing on the classification and interpretation of bovine sperm defects. Building upon the success of its first edition published in 1989, this new edition has been significantly updated and expanded to reflect developments over the past three decades.
1 224 kr
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1 446 kr
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Across centuries, the study of human anatomy has stood at the intersection of science, ethics, and culture. This volume offers a critical synthesis of how anatomical knowledge has been pursued, contested, and transformed from Renaissance dissection theatres to today’s virtual reality labs. It examines anatomy not merely as a technical discipline but as a cultural artefact—shaped by artistic representation, political power, and evolving pedagogical norms.Contributors trace the ethical dilemmas of cadaveric dissection, the artistry of wax modelling and medical illustration, and the disruptive potential of digital and AI-driven tools. Case studies explore Vesalius’ revolutionary methods, the illicit economies of 19th-century body procurement, and the colonial legacies embedded in anatomical collections. Contemporary chapters interrogate gender bias in medical imaging, the rise of ultrasound and plastination, and the challenges of decolonising curricula.Bringing together historians, clinicians, educators, and ethicists, this interdisciplinary work situates anatomy within broader debates on professional identity, social justice, and technological innovation. It argues that understanding anatomy’s past—its exclusions, exploitations, and epistemic struggles—is essential for shaping an ethical and inclusive future in medical education.Ideal for scholars and practitioners in history of medicine, medical ethics, surgical education, and cultural studies, this book provides a nuanced framework for rethinking anatomy as both scientific practice and social institution.
Del 215 - Advances in Anatomy, Embryology and Cell Biology
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
Häftad, Engelska, 2014
1 778 kr
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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase.
Del 216 - Advances in Anatomy, Embryology and Cell Biology
Regulation of Implantation and Establishment of Pregnancy in Mammals
Tribute to 45 Year Anniversary of Roger V. Short's "Maternal Recognition of Pregnancy"
Häftad, Engelska, 2015
1 114 kr
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Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.
Del 217 - Advances in Anatomy, Embryology and Cell Biology
Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
Häftad, Engelska, 2015
1 114 kr
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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
Del 218 - Advances in Anatomy, Embryology and Cell Biology
Metallothioneins in Normal and Cancer Cells
Häftad, Engelska, 2016
560 kr
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This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
Del 219 - Advances in Anatomy, Embryology and Cell Biology
Focus on Bio-Image Informatics
Häftad, Engelska, 2016
1 081 kr
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This volume of Advances Anatomy Embryology and Cell Biology focuses on the emerging field of bio-image informatics, presenting novel and exciting ways of handling and interpreting large image data sets.
Del 220 - Advances in Anatomy, Embryology and Cell Biology
Sperm Acrosome Biogenesis and Function During Fertilization
Häftad, Engelska, 2016
1 114 kr
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Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reportedin neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
Disordered Vertebral and Rib Morphology in Pudgy Mice
Structural Relationships to Human Congenital Scoliosis
Häftad, Engelska, 2016
1 114 kr
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This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
1 556 kr
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Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.
1 556 kr
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Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
1 667 kr
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Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences inthe establishment and maintenance of virus persistence will be covered.
Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy
Häftad, Engelska, 2017
1 556 kr
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This book elucidates the mechanisms involved in biological membrane functions.It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics.The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).
Del 226 - Advances in Anatomy, Embryology and Cell Biology
Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia
Häftad, Engelska, 2018
1 224 kr
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This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment.
Del 229 - Advances in Anatomy, Embryology and Cell Biology
Chromatin Regulation of Early Embryonic Lineage Specification
Häftad, Engelska, 2017
1 335 kr
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Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.
1 224 kr
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This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
Pulvinar Thalamic Nucleus of Non-Human Primates: Architectonic and Functional Subdivisions
Häftad, Engelska, 2017
1 189 kr
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This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional and behavioral requirements of each species.The pulvinar, the largest nucleus of the primate thalamus, has extensive and reciprocal connections with several areas of the neocortex. These input-output loops suggest that the pulvinar may regulate the flow of information within and between cortical areas in a highly dynamic fashion. Therefore, understanding the anatomical subdivisions within the pulvinar, and its connectivity with the cortex, is paramount to understanding pulvinar physiological function. However, there is a stark contrast regarding the way that the pulvinar is subdivided depending on the technique employed. Cytoarchitectural and immunohistochemical methods reveal a very similar pattern of pulvinar subdivision across Old- and New-World monkeys. On the other hand, electrophysiological and connectivity studies expose clear discrepancies in pulvinar organization across primate evolution.
Del 169 - Advances in Anatomy, Embryology and Cell Biology
Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head
Häftad, Engelska, 2003
1 114 kr
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The molecular cascades that control craniofacial development have until recently been little understood. The paucity of data that exists has in part been due to the complexity of the head, which is a unique, and possibly one of the most intricate regions of the body. However, the generation of mouse mutants, the identification of gene mutations that cause human craniofacial syndromes, together with classical embryological approaches in other species has now given significant insight how the head develops.
Del 172 - Advances in Anatomy, Embryology and Cell Biology
Sensory Circumventricular Organs of the Mammalian Brain
Subfornical Organ, OVLT and Area Postrema
Häftad, Engelska, 2003
1 114 kr
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This is the only book entirely devoted to the sensory circumventricular organs. It reviews research into their detailed anatomy, neurochemistry, neural connections, and functions, and provides the reader with many illustrations previously unpublished.