Frederic Shapiro – författare

Volume 2 of this comprehensive and state-of-the-art text on pediatric orthopedic deformities focuses on conditions of the lower extremity. Developmental disorders of the hip – developmental dysplasia of the hip (DDH), Legg-Calvé-Perthes disease (LCP), coxa vara including slipped capital femoral epiphysis (SCFE), and femoroacetabular impingement (FAI) – the knee, the ankle and foot, as well as rotational and angular deformities of the lower limb are discussed in detail. Presentation for each deformity includes: definition, detailed review of the pathoanatomy, experimental biological investigations (where applicable), natural history, review of the evolution of diagnostic and treatment techniques, results achieved with the various approaches, and current management approaches with detailed descriptions of surgical technique. Extensive illustrations, figures and photos provide clear visual depictions of the range of deformity for the various disorders, underlying histopathology, imaging findings and treatment approaches. Multiple tables provide concentrated information, especially for the treatment options based on the severity of the particular disorder and deformity.Based on a solid understanding of the underlying pathobiology of deformities of the developing musculoskeletal system, this second volume of Pediatric Orthopedic Deformities provides a penetrating, in-depth presentation on the lower extremity for pediatric orthopedic surgeons, adult orthopedic surgeons seeking a deeper understanding of how deformities developed, and all clinicians caring for pediatric patients with developmental deformities.

Developmental biology of normal bone and cartilage including histogenesis, molecular/gene and biomechanical aspects is updated and expanded. The book outlines the biology of: bone repair with differing mechanical environments; cartilage repair at articular and physeal sites; and distraction osteogenesis. The generously illustrated text provides an in-depth presentation of the interplay between normal developmental biology, abnormal pathologic states and the influence of operative and non-operative orthopedic interventions on childhood orthopedic deformity. Thirty-four principles underlying the development, progression and management of skeletal deformity in the growing child are defined. Orthopedic management including surgical treatment is discussed for: skeletal dysplasias; epiphyseal growth plate fracture-separations; lower extremity length discrepancies; and deformities of joints and epiphyses due to metabolic, inflammatory, infectious, hematologic, and neoplastic disorders. Treatments are related to extent of deformity, remodeling post-surgery and possible recurrence.This 2nd edition of Pediatric Orthopedic Deformities has been expanded to cover more regions and disorders and is being presented in 3 volumes.

​This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.