Chromatin Regulation of Early Embryonic Lineage Specification

Häftad, Engelska, 2017

Del 229 i serien Advances in Anatomy, Embryology and Cell Biology

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Beskrivning

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

Produktinformation

Utgivningsdatum:2017-12-08
Mått:155 x 235 x 5 mm
Vikt:165 g
Format:Häftad
Språk:Engelska
Serie:Advances in Anatomy, Embryology and Cell Biology
Antal sidor:78
Upplaga:17001
Förlag:Springer International Publishing AG
ISBN:9783319631868

Utforska kategorier

Fysiologi inom Medicin
Cellbiologi inom Naturvetenskap och teknik
Medicinsk genetik inom Medicin

Mer om författaren

Dr. Jason Knott is a reproductive and developmental biologist with fifteen years of experience in mammalian embryology and stem cell biology. His research program is focused on elucidating chromatin based mechanisms that regulate gene expression programs and cell-fate determination in preimplantation embryos and embryonic stem cells. His current research focus is on understanding transcriptional and epigenetic mechanisms that govern cell polarity, pluripotency, trophoblast lineage formation, and trophoblast lineage differentiation in mice, humans, and cattle. Dr. Keith Latham is a developmental biologist with nearly three decades of experience in mammalian embryology. His research encompasses epigenetics and imprinting in the early embryo, transcriptional control, translational control, determinants of oocyte quality, and mechanisms underlying meiotic spindle formation and function. His research combines the use of diverse mouse strains, molecular assays applicable to the single cell level, and embryo micromanipulation including different forms of nuclear transfer.

Innehållsförteckning

CHD1 controls cell lineage specification through zygotic genome activation.- Chromatin remodelling proteins and cell fate decisions in mammalian preimplantation development.- Transcriptional regulation and genes involved in first lineage specification during preimplantation development.- ROCK and RHO playlist for preimplantation development: Streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation.- XEN and the art of stem cell maintenance - molecular mechanisms maintaining cell fate and self-renewal in extraembryonic endoderm stem (XEN) cell lines.