Gene Therapy for Autoimmune and Inflammatory Diseases

"The information is quite extensive and useful. Each chapter is well referenced. This monograph is highly specialized but is easily understandable. It is recommended for all researchers - both clinical and non-clinical, particularly those working in the fields of gene therapy, immunology, rheumatology, pharmacology and molecular medicine. It will also be a useful reference source for the libraries of all advanced academic centers and research institutions." (S. S. Agarwal, Indian Journal of Medical Research, Vol. 135, April, 2012) "This monograph contains new and valuable information regarding relevant topics ranging from disease entities to vectors and engineered cells. The authors, all of them international experts, take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long term genetic interventions. ... The present volume is of an exceptional value for clinicians and scientists interested in introducing gene therapy into clinical use." (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

• Gene therapy for arthritis.- Gene therapy for the treatment of inflammatory bowel disease.- Gene therapy for diabetes.- Gene therapy for cystic fibrosis lung disease.- Gene therapy of multiple sclerosis.- Gene therapy for myositis.- Gene therapy for osteoarthritis.- Gene therapy: Sjögren’s syndrome.- Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease.- Regulated promoters.- Development of AAV vectors for the therapy of autoimmune and inflammatory diseases.- Delivery and application of plasmid DNA in arthritis gene therapy.- Helper-dependent adenoviral vectors.- Cells as carriers of gene therapy.- Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy.