Milestones in Drug Therapy – serie
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73 produkter
Drugs for HER-2-positive Breast Cancer
Av Maria Sibilia, Christoph C. Zielinski m. fl.
Inbunden, 2011
1692 kr
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Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the …
Gene Therapy for Autoimmune and Inflammatory Diseases
Av Yuti Chernajovsky, Paul D. Robbins
Inbunden, 2010
2253 kr
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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described …
Glutamate-based Therapies for Psychiatric Disorders
Inbunden, 2010
1692 kr
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Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the …
Treatment and Prevention of Malaria
Antimalarial Drug Chemistry, Action and Use
Av Henry M. Staines, Sanjeev Krishna
Inbunden, 2012
1692 kr
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Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the …
Twenty Years of G-CSF
Clinical and Nonclinical Discoveries
Av Graham Molineux, MaryAnn Foote m. fl.
Inbunden, 2012
2253 kr
Lägg i varukorg
Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a …
Gene Therapy for Autoimmune and Inflammatory Diseases
Av Yuti Chernajovsky, Paul D. Robbins
Häftad, 2012
2253 kr
Lägg i varukorg
In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described …
Drugs for HER-2-positive Breast Cancer
Av Maria Sibilia, Christoph C. Zielinski m. fl.
Häftad, 2013
1692 kr
Lägg i varukorg
Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the …
Tamoxifen
Pioneering Medicine in Breast Cancer
Av Philipp Y. Maximov, Russell E. McDaniel m. fl.
Inbunden, 2013
2029 kr
Lägg i varukorg
Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years.This …
Drugs Targeting B-Cells in Autoimmune Diseases
Av Xavier Bosch, Manuel Ramos-Casals m. fl.
Inbunden, 2013
1804 kr
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This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are …
Indacaterol
The First Once-daily Long-acting Beta2 Agonist for COPD
Inbunden, 2013
1128 kr
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Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are …
Influenza Virus Sialidase - A Drug Discovery Target
Häftad, 2014
1692 kr
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Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume …
Tamoxifen
Pioneering Medicine in Breast Cancer
Av Philipp Y. Maximov, Russell E. McDaniel m. fl.
Häftad, 2015
2029 kr
Lägg i varukorg
Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years.This …
Twenty Years of G-CSF
Clinical and Nonclinical Discoveries
Av Graham Molineux, MaryAnn Foote m. fl.
Häftad, 2014
2253 kr
Lägg i varukorg
Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a …
Treatment and Prevention of Malaria
Antimalarial Drug Chemistry, Action and Use
Av Henry M. Staines, Sanjeev Krishna
Häftad, 2014
1692 kr
Lägg i varukorg
Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the …
Treatment of Cystic Fibrosis and Other Rare Lung Diseases
Av Arata Azuma, Michael S. Schechter
Inbunden, 2017
1580 kr
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This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions.It focuses on the treatment of cystic fibrosis …
Inhibitors of Monoamine Oxidase B
Pharmacology and Clinical Use in Neurodegenerative Disorders
Häftad, 2014
531 kr
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ACE Inhibitors
Av Pedro D'Orléans-Juste, G.E. Plante
Häftad, 2012
569 kr
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Angiotensin converting enzyme inhibitors (ACEI) represent the first class of antihypertensive agents that was designed and developed on the basis of a well-defined physiopathological axis of arterial hypertension, a vascular dis order that is now becoming one of the major causes of …
Fluoroquinolone Antibiotics
Av Allan R. Ronald, Donald Low
Häftad, 2012
1128 kr
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Since the introduction of ciprofloxacin in 1987, fluoroquinolones have expanded far beyond their early role in the treatment of urinary tract infections. Clinical applications beyond genitourinary tract infections include upper and lower respiratory infections, gastrointestinal infections, …
Macrolide Antibiotics
Häftad, 2012
1692 kr
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There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin …
HMG-CoA Reductase Inhibitors
Av Gerd Schmitz, Michael Torzewski
Häftad, 2012
1128 kr
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HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book …
Antidepressants
Häftad, 2012
903 kr
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Important clinical issues as the outcome of long term treatment with antidepressants, the time of onset of the antidepressant response and the limitations of the antidepressants currently available are covered in this monograph. Leading researchers in the area of clinical and experimental …
Recombinant Protein Drugs
Av P. Buckel
Häftad, 2012
1692 kr
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Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical …
Glucocorticoids
Av N.J. Goulding, Roderick Flower
Häftad, 2012
569 kr
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Following 50 years of glucocorticoid use in a clinical setting, an international body of expert scientists and physicians presents the most expansive survey of glucocorticoid pharmacology to date. This work traces the history of glucocorticoid biology from the seminal description of glucocorticoid …
Modern Immunosuppressives
Av H.-J. Schuurman, G. Feutren m. fl.
Häftad, 2012
569 kr
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Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine. Immunosuppressants are at the forefront of new treatment modalities. Individual chapters focus on their use not only in prevention or …
Atypical Antipsychotics
Av Bart A. Ellenbroek, Alexander R. Cools
Häftad, 2012
2253 kr
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The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill ness, it allowed, for the first time, to adequately control the severe …
Methotrexate
Av Bruce N. Cronstein, Joseph R. Bertino
Häftad, 2012
569 kr
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Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which …
Anxiolytics
Häftad, 2012
1128 kr
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For over thirty years the benzodiazepines monopolised not only the anxiolytic market but also clinical and animal research in anxiety. Indeed many animal tests developed since the 1960s have been optimised for the benzodiazepines and some programmes have even screened candidates as potential …
Calcium Channel Blockers
Häftad, 2012
1692 kr
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The drugs named calcium channel blockers (CCBs) were initially termed cal cium antagonists (see Chapter 1). They are also designated as calcium entry blockers (CEBs), calcium blockers, calcium channel antagonists, calcium channel inhibitors (and in French anticalciques). As this is reported in …
Cognitive Enhancing Drugs
Häftad, 2012
1128 kr
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During the past decade research into the pharmacology of cognition, particularly regarding learning and memory, has supported the concept that many potential neural targets exist for the development of cognitive-enhancing drugs. Whereas the main impetus for this research has been the ever growing …
Combination Therapy of AIDS
Av Erik De Clercq, Anne-Mieke Vandamme
Häftad, 2012
1692 kr
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HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a …
