Treatment and Prevention of Malaria

Antimalarial Drug Chemistry, Action and Use

AvHenry M. Staines,Sanjeev Krishna

Inbunden, Engelska, 2012

Del i serien Milestones in Drug Therapy

1 637 kr

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Beskrivning

Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.

Produktinformation

Utgivningsdatum:2012-01-06
Mått:155 x 235 x 22 mm
Vikt:624 g
Format:Inbunden
Språk:Engelska
Serie:Milestones in Drug Therapy
Antal sidor:318
Upplaga:2012
Förlag:Birkhauser Verlag AG
ISBN:9783034604796

Utforska kategorier

Infektionssjukdomar och smittsamma sjukdomar inom Medicin
Patologi inom Medicin
Onkologi inom Medicin

Recensioner i media

From the reviews: "Staines and Krishna successfully captures the essence of what we know about antimalarials at the beginning of the second decade of the 21st century. ... the book is a welcome and highly valuable documentation on where we stand and offers valuable food for thought in the search for the way forward." (Martin P. Grobusch, Trends in Parasitology, September, 2012)

Innehållsförteckning

Antimalarial drugs and the control and elimination of malaria.- 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues.- Cinchona alkaloids: quinine and quinidine.- 8-Aminoquinolines: primaquine and tafenoquine.- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine.- Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone.- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions.- Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin.- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate.- Second generation peroxides: the OZs and artemisone.- Combination therapy in light of emerging artemisinin resistance.- New medicines to combat malaria: an overview of the global pipeline of therapeutics.- Molecular markers of Plasmodium resistance to antimalarials.- Prevention of malaria.- Malaria diagnostics: lighting the path.