Multicomponent Reactions

Applications in Organic Synthesis and Drug Discovery

Inbunden, Engelska, 2026

3 368 kr

Kommande

Beskrivning

Comprehensive coverage of sustainable multicomponent reactions across multiple disciplines Multicomponent reactions (MCRs) enable the combination of three or more starting materials in a single vessel to afford diverse and complex products while aligning with green chemistry principles. Multicomponent Reactions: Applications in Organic Synthesis and Drug Discovery summarizes the most recent MCR applications and emerging trends, providing expert knowledge on current advancements across organic chemistry, medicinal chemistry, polymer and analytical chemistry. The book explores sustainable chemical approaches, such as electrochemistry, photochemistry, mechanochemistry, and flow chemistry. It also covers biocatalytic MCRs, reactions in non-conventional solvents, isotope labeling, and late-stage functionalization. Additional topics include: Artificial intelligence and automated synthesis (HTS) enhancing MCRs workflows in research laboratoriesDrug discovery applications demonstrating how MCRs rapidly generate diverse chemical libraries of heterocycles and bioactive compounds, including protein degradersReactive intermediates and reaction mechanisms in multicomponent processesInnovative approaches for designing advanced materials with specific functional propertiesMCRs in chemical educationMulticomponent Reactions: Applications in Organic Synthesis and Drug Discovery will benefit organic chemists, medicinal chemists, materials scientists, and chemical engineers, providing them with practical knowledge of sustainable synthetic methods from expert contributors across various research fields.

Produktinformation

Utgivningsdatum:2026-10-07
Mått:170 x 244 x undefined mm
Format:Inbunden
Språk:Engelska
Antal sidor:864
Förlag:Wiley-VCH Verlag GmbH
ISBN:9783527355617

Utforska kategorier

Farmakologi inom Medicin
Fysikalisk kemi inom Naturvetenskap och teknik
Biokemisk teknik inom Naturvetenskap och teknik

Mer om författaren

Mariateresa Giustiniano is an associate professor at the University of Naples Federico II in Italy. She has co-authored over 60 peer-reviewed publications and four book chapters, with research interests spanning multicomponent reactions, visible-light photocatalysis, and their application in medicinal chemistry for discovering new anticancer agents.

Innehållsförteckning

Preface xi1 Multicomponent Reactions for a Sustainable Organic Synthesis 1Elena Cassera, Davide Ravelli, Mariateresa Giustiniano, and Maurizio Fagnoni2 Light-triggered Multicomponent Reactions 33Lorenzo Di Terlizzi and Stefano Protti3 Multicomponent Electrochemical Strategies for Modern Organic Synthesis 55Rajesh Kumar, Vinay Thatikonda, and Upendra K. Sharma4 Mechanochemical Multicomponent Reactions 79Francesco Basoccu, Dipak J. Fartade, and Andrea Porcheddu5 The Use of Microwave-assisted Multicomponent Reactions for the Synthesis of Heterocycles Containing Isatin or Organophosphorus Moiety 119Dániel Steinsits and Erika Bálint6 Biocatalytic Multicomponent Reactions 141Camilla Russo, Flora Antoniou, and Daniele Castagnolo7 Isocyanide-based Multicomponent Reactions in Aqueous Media 185Mohammad Taghi Nazeri, Tahereh Nasiriani, Nuhaa Shaheed, and Ahmad Shaabani8 Non-isocyanide-based Multicomponent Reactions in Aqueous Media 243Mohammad Taghi Nazeri, Tahereh Nasiriani, Nuhaa Shaheed, and Ahmad Shaabani9 The Use of Nonconventional Solvents in Multicomponent Reactions 301Yavar Ahmadi and Ali Ramazani10 Nanoreactors Technology in Multicomponent Reactions 325Seyedmohammad Hosseininezhad, Melika Seydi, and Ali Ramazani11 Multicomponent Reactions in Automated Synthetic Chemistry 375Imma Capriello and Alexander Domling12 Scale-up and Automation of Multicomponent Reactions via Continuous Flow 405Johannes Bingold, Andreas Brunschweiger, and Norbert Kockmann13 Investigating Multicomponent Reactions Mechanisms 435Brenno A. D. Neto, Giovanni W. Amarante, and Alexandre A. M. Lapis14 Reactive Intermediates in Isocyanide-based Multicomponent Reactions 457Ana G. Neo and Carlos F. Marcos15 Heterocycle-based Multicomponent Reactions 489Pau Nadal-Rodríguez, Ouldouz Ghashghaei, and Rodolfo Lavilla16 Multicomponent Synthesis of Functional Chromophores 513Larissa Brandner and Thomas J. J. Müller17 Atropisomers and Molecular Balances via Multicomponent Reactions 543Michael Fragkiadakis, Michael Kapsalis, and Constantinos Neochoritis18 Multicomponent Synthesis of Organoselenium Compounds 565Paola S. Hellwig, Thiago A. Ribeiro, Mateus W. Rambo, Kethelyn M. Rosa, Nicole M. N. Washio, Ricardo F. Schumacher, Eder J. Lenardão, and Filipe Penteado19 Multicomponent Reactions in Isotope Labeling 613Kevin Schofield, Aidan McMahon, Vishal Kaleeswaran, Sean Ginn, and Christopher Hulme20 Harnessing Multicomponent Reactions for the Functionalization of Drugs and Bioactive Natural Products via Innate Reactivity 637Hélène Beucher and Tatiana Besset21 Multicomponent Reactions for the Synthesis of Protein Degraders 659Laura Gioiello, Tracey Pirali and Rita Maria Concetta Di Martino22 Synthesis of Natural Compounds via Multicomponent Reactions 689Ana Barbero-Moreno, Miriam Ruiz, and J. Carlos Menéndez23 Multicomponent Reactions in the Total Synthesis of Biologically Active Natural Products– Part I: Reactions Based on the Use of Isocyanides, Transition Metal Catalysis, and Tandem Conjugate Addition/Electrophilic Enolate Trapping on α , β -Unsaturated Carbonyls 711Enrique L. Larghi, Andrea B. J. Bracca, Sebastián O. Simonetti, and Teodoro S. Kaufman24 Multicomponent Reactions in the Total Synthesis of Biologically Active Natural Products– Part II: MCRs Initiated by Nucleophilic Addition to Carbonyl Compounds, Mannich and Related Reactions, Anion Relay Chemistry, [4+2]-Cycloadditions and Other Transformations 741Enrique L. Larghi, Andrea B. J. Bracca, Sebastián O. Simonetti, and Teodoro S. Kaufman25 Multicomponent Reactions in Polymer Chemistry 767Siamak Javanbakht, Reza Mohammadi, and Ahmad Shaabani26 Multicomponent Derivatization for Advanced Gas and Liquid Chromatographic Methods 785Serban C. Moldoveanu and Victor David27 Multicomponent Reactions in Chemical Education 809Cristina Martini and Andrea BassoIndex 831