G Protein-Coupled Receptors

Xinfeng Zhao is a Professor in the College of Life Sciences at Northwest Univer[1]sity (Xi’an, China) since 2016. He received his B.S. and M.S. in Chemistry from Northwest University in 2001 and Xi’an Jiaotong University in 2005, respectively. He obtained his doctorate in pharmacology in 2009 at Xi’an Jiaotong University and then pursued postdoctoral studies in pharmacology at the University of Cambridge (Cambridge, UK) in 2010. In 2009, he joined Northwest University as a Lecturer and was promoted to Associate Professor in 2013. He has been a Senior Visiting Scholar in the Department of Chemistry at Purdue University (West Lafayette, IN, USA) in 2017. His research interests are in the areas of immobilized GPCRs and applications, GPCR-drug interaction analysis, and bioactive compound screening from herbal medicines.Qian Li received her doctorate in Pharmaceutical Analysis in 2016 and pursued post[1]doctoral studies in biology at Northwest University (Xi’an, China).Her dissertation focused on the establishment and application of chromatographic methods based on immobilized GPCRs. In 2018, she joined Northwest University as a Lecturer and was appointed an Associate Professor in the College of Life Sciences in 2020. In 2018, she moved to the Department of Chemistry at Purdue University (West Lafayette, IN, USA) as a visiting scholar. Her current interests lie in the area of immobilized GPCRs and their applications.Jing Wang joined the faculty as a Lecturer in the College of Life Sciences at Northwest University (Xi’an, China). She received her Ph.D. in Medicinal Chemistry in 2019 from Northwest University under the direction of Professor Xinfeng Zhao. Her research efforts are primarily directed toward the immobilization of GPCRs (e.g. beta2-adrenoceptor and leukotriene receptor) through bioorthogonal reaction and their application in receptor-ligand interaction analysis and lead compound screening from natural products. Qi Liang received his received his B.S. in Life Sciences and M.S. in Pharmacology from Northeast Forestry University (Harbin, China) in 2010 and Xi’an Jiaotong University (Xi’an, China) in 2013, respectively. In 2021, he obtained his Ph.D. in medicinal chemistry from Northwest University (Xi’an, China) under the direction of Prof. Xinfeng Zhao. Afterwards, he was engaged in his postdoctoral work in the same group. His research interests are screening the ligands of GPCR from DNA-encoded library. Jia Quan received his B.S. and Ph.D. from Northwest University (Xi’an, China) in 2015 and Wuhan University (Wuhan, China) in 2021, respectively. In 2022, he joined the group of Prof. Xinfeng Zhao at Northwest University as a postdoctoral fellow. His research project focuses on the virus-encoded GPCRs and the screening for new antivirus drugs.

• G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening.