Michael J. Campbell – författare

The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such as trials conducted at earlier stages of drug development.  With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design. This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy.Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.

An authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studiesNow in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studiesincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed.This revised fourth edition: Offers the only text available to include sample size software for use in designing and planning clinical studiesPresents new and extended chapters with many additional and refreshed examplesIncludes clear explanations of the principles and methodologies involved with relevant practical examplesMakes clear a complex but vital topic that is designed to ensure valid methodology and publishable results Contains guidance from an internationally recognised team of medical statistics expertsWritten for medical researchers from all specialities and medical statisticians, Sample Sizes for Clinical, Laboratory and EpidemiologyStudies offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.

STATISTICS AT SQUARE ONE The new edition of the popular introduction to the world of statistics for health care professionals and medical studentsFirst published nearly three decades ago, Statistics at Square One remains one of the most popular introductions to medical statistics. Now in its twelfth edition, this international bestseller continues to be a must-have resource for anyone in need of a thorough introduction to statistics in the health sciences. Clear and accessible chapters help students with no previous background in the subject understand fundamental topics including summary statistics for quantitative and binary data, diagnostic and screening tests, populations and samples, survival analysis, correlation and regression, study design, computer modeling, and more.This edition reflects contemporary understanding of medical statistics and emphasizes the importance of statistics in public health, including extensively updated coverage of diagnostic tests and new COVID-related examples. All figures and examples now include code to reproduce them in the R statistical software. New chapters cover the basics for understanding numbers and introduce the use of models in medical statistical analysis. Based on the author’s many years of experience teaching medical and health science students, the latest edition of this classic textbook:Highlights the connections between different medical statistics methodsEmphasizes the proper use of p-values in testingFeatures practical examples from recent literatureContains end-of-chapter exercises with answers, some of which are based on the Royal College of General Practitioners (RCGP) Advanced Knowledge TestStatistics at Square One is required reading for all medical and health care practitioners and students wanting to understand the use and value of statistical analysis in the health sciences.

STATISTICS AT SQUARE TWO An easy-to-follow exploration of intermediate statistical techniques used in medical research In the newly revised third edition of Statistics at Square Two: Understanding Modern Statistical Applications in Medicine, a team of distinguished statisticians delivers an accessible and intuitive discussion of advanced statistical methods for readers and users of scientific medical literature. This will allow readers to engage critically with modern research as the authors explain the correct interpretation of results in the medical literature. The book includes two brand new chapters covering meta-analysis and time-series analysis as well as new references to the many checklists that have appeared in recent years to enable better reporting of contemporary research. Most examples have been updated as well, and each chapter contains practice exercises and answers. Readers will also find sample code (in R) for many of the analyses, in addition to: A thorough introduction to models and data, including the different types of data, statistical models, and computer-intensive methodsComprehensive explorations of multiple linear regression, including the interpretation of computer output, diagnostic statistics such as influential points, and many uses of multiple regressionPractical discussions of multiple logistic regression, survival analysis, Poisson regression and random effects models including their uses, examples in the medical literature, and strategies for interpreting computer outputPerfect for anyone hoping to better understand the statistics presented in contemporary medical research, Statistics at Square Two: Understanding Modern Statistical Applications in Medicine will also benefit postgraduate students studying statistics and medicine.

The 5th Edition of this popular introduction to statistics for the medical and health sciences has undergone a significant revision, with several new chapters added and examples refreshed throughout the book. Yet it retains its central philosophy to explain medical statistics with as little technical detail as possible, making it accessible to a wide audience.Helpful multi-choice exercises are included at the end of each chapter, with answers provided at the end of the book.  Each analysis technique is carefully explained and the mathematics kept to minimum. Written in a style suitable for statisticians and clinicians alike, this edition features many real and original examples, taken from the authors' combined many years' experience of designing and analysing clinical trials and teaching statistics.Students of the health sciences, such as medicine, nursing, dentistry, physiotherapy, occupational therapy, and radiography should find the book useful, with examples relevant to their disciplines. The aim of training courses in medical statistics pertinent to these areas is not to turn the students into medical statisticians but rather to help them interpret the published scientific literature and appreciate how to design studies and analyse data arising from their own projects.  However, the reader who is about to design their own study and collect, analyse and report on their own data will benefit from a clearly written book on the subject which provides practical guidance to such issues.The practical guidance provided by this book will be of use to professionals working in and/or managing clinical trials, in academic, public health, government and industry settings, particularly medical statisticians, clinicians, trial co-ordinators. Its practical approach will appeal to applied statisticians and biomedical researchers, in particular those in the biopharmaceutical industry, medical and public health organisations.

A complete guide to understanding cluster randomised trials Written by two researchers with extensive experience in the field, this book presents a complete guide to the design, analysis and reporting of cluster randomised trials. It spans a wide range of applications: trials in developing countries, trials in primary care, trials in the health services. A key feature is the use of R code and code from other popular packages to plan and analyse cluster trials, using data from actual trials.  The book contains clear technical descriptions of the models used, and considers in detail the ethics involved in such trials and the problems in planning them. For readers and students who do not intend to run a trial but wish to be a critical reader of the literature, there are sections on the CONSORT statement, and exercises in reading published trials. Written in a clear, accessible styleFeatures real examples taken from the authors’ extensive practitioner experience of designing and analysing clinical trialsDemonstrates the use of R, Stata and SPSS for statistical analysisIncludes computer code so the reader can replicate all the analysesDiscusses neglected areas such as ethics and practical issues in running cluster randomised trialsHow to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research provides an excellent reference tool and can be read with profit by statisticians, health services researchers, systematic reviewers and critical readers of cluster randomised trials.