Design of Studies for Medical Research

Häftad, Engelska, 2005

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Beskrivning

The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such as trials conducted at earlier stages of drug development. With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design. This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy.Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.

Produktinformation

Utgivningsdatum:2005-02-11
Mått:170 x 245 x 17 mm
Vikt:539 g
Format:Häftad
Språk:Engelska
Antal sidor:288
Förlag:John Wiley & Sons Inc
ISBN:9780470844953

Utforska kategorier

Medicinsk utrustning och medicinska tekniker inom Medicin

Mer om författaren

David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore and UK Children's Cancer Study Group, University of Leicester, UK and Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK Michael J. Campbell, Medical Statistics Group, Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK

Recensioner i media

"…a thorough but concise introduction to study design and data analysis." (E-STREAMS, June 2006) "…a very good attempt to discuss various aspects of clinical research…" (Journal of Biopharmaceutical Statistics, July/August 2006)"This is a well researched, well written, thoughtful, and…easy to read primer…a valuable addition to books for research physicians, medical students, and others…" (Doody's Health Services)"…this book is surprisingly refreshing…could be used in any number of situations with equality utility…" (Canadian Journal of Medical Laboratory Science, 2005)

Innehållsförteckning

Preface ixChapter 1 What is Evidence? 1Chapter 2 Measurement, Forms and Questionnaires 18Chapter 3 Principles of Study Size Calculation 37Chapter 4 Randomisation 59Chapter 5 Cross-sectional and Longitudinal Studies 78Chapter 6 Surveys, Cohort and Case–Control Studies 109Chapter 7 Clinical Trials–General Issues 139Chapter 8 Early Clinical Trials 160Chapter 9 Phase III Trials 188Chapter 10 Diagnosis 209Chapter 11 Prognostic Factor Studies 227References 246Tables 255Index 267