Bradley P. Carlin - Böcker

Hierarchical Modeling and Analysis for Spatial Data, Third Edition is the latest edition of this popular and authoritative text on Bayesian modeling and inference for spatial and spatial-temporal data. The text presents a comprehensive and up-to-date treatment of hierarchical and multilevel modeling for spatial and spatio-temporal data within a Bayesian framework. Over the past decade since the second edition, spatial statistics has evolved significantly driven by an explosion in data availability and advances in Bayesian computation. This edition reflects those changes, introducing new methods, expanded applications, and enhanced computational resources to support researchers and practitioners across disciplines, including environmental science, ecology, and public health.Key features of the third edition:A dedicated chapter on state-of-the-art Bayesian modeling of large spatial and spatio-temporal datasetsTwo new chapters on spatial point pattern analysis, covering both foundational and Bayesian perspectivesA new chapter on spatial data fusion, integrating diverse spatial data sources from different probabilistic mechanismsAn accessible introduction to GPS mapping, geodesic distances, and mathematical cartographyAn expanded special topics chapter, including spatial challenges with finite population modeling and spatial directional dataA thoroughly revised chapter on Bayesian inference, featuring an updated review of modern computational techniquesA dedicated GitHub repository providing R programs and solutions to selected exercises, ensuring continued access to evolving software developmentsWith refreshed content throughout, this edition serves as an essential reference for statisticians, data scientists, and researchers working with spatial data. Graduate students and professionals seeking a deep understanding of Bayesian spatial modeling will find this volume an invaluable resource for both theory and practice.

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel.

Keep Up to Date with the Evolving Landscape of Space and Space-Time Data Analysis and ModelingSince the publication of the first edition, the statistical landscape has substantially changed for analyzing space and space-time data. More than twice the size of its predecessor, Hierarchical Modeling and Analysis for Spatial Data, Second Edition reflects the major growth in spatial statistics as both a research area and an area of application.New to the Second Edition New chapter on spatial point patterns developed primarily from a modeling perspectiveNew chapter on big data that shows how the predictive process handles reasonably large datasetsNew chapter on spatial and spatiotemporal gradient modeling that incorporates recent developments in spatial boundary analysis and womblingNew chapter on the theoretical aspects of geostatistical (point-referenced) modeling Greatly expanded chapters on methods for multivariate and spatiotemporal modelingNew special topics sections on data fusion/assimilation and spatial analysis for data on extremesDouble the number of exercises Many more color figures integrated throughout the textUpdated computational aspects, including the latest version of WinBUGS, the new flexible spBayes software, and assorted R packagesThe Only Comprehensive Treatment of the Theory, Methods, and SoftwareThis second edition continues to provide a complete treatment of the theory, methods, and application of hierarchical modeling for spatial and spatiotemporal data. It tackles current challenges in handling this type of data, with increased emphasis on observational data, big data, and the upsurge of associated software tools. The authors also explore important application domains, including environmental science, forestry, public health, and real estate.

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel.