Bradley P. Carlin – författare

Hierarchical Modeling and Analysis for Spatial Data, Third Edition is the latest edition of this popular and authoritative text on Bayesian modeling and inference for spatial and spatial-temporal data. The text presents a comprehensive and up-to-date treatment of hierarchical and multilevel modeling for spatial and spatio-temporal data within a Bayesian framework. Over the past decade since the second edition, spatial statistics has evolved significantly driven by an explosion in data availability and advances in Bayesian computation. This edition reflects those changes, introducing new methods, expanded applications, and enhanced computational resources to support researchers and practitioners across disciplines, including environmental science, ecology, and public health.Key features of the third edition:A dedicated chapter on state-of-the-art Bayesian modeling of large spatial and spatio-temporal datasetsTwo new chapters on spatial point pattern analysis, covering both foundational and Bayesian perspectivesA new chapter on spatial data fusion, integrating diverse spatial data sources from different probabilistic mechanismsAn accessible introduction to GPS mapping, geodesic distances, and mathematical cartographyAn expanded special topics chapter, including spatial challenges with finite population modeling and spatial directional dataA thoroughly revised chapter on Bayesian inference, featuring an updated review of modern computational techniquesA dedicated GitHub repository providing R programs and solutions to selected exercises, ensuring continued access to evolving software developmentsWith refreshed content throughout, this edition serves as an essential reference for statisticians, data scientists, and researchers working with spatial data. Graduate students and professionals seeking a deep understanding of Bayesian spatial modeling will find this volume an invaluable resource for both theory and practice.

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel.

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel.

Broadening its scope to nonstatisticians, Bayesian Methods for Data Analysis, Third Edition provides an accessible introduction to the foundations and applications of Bayesian analysis. Along with a complete reorganization of the material, this edition concentrates more on hierarchical Bayesian modeling as implemented via Markov chain Monte Carlo (MCMC) methods and related data analytic techniques. New to the Third Edition New data examples, corresponding R and WinBUGS code, and homework problems Explicit descriptions and illustrations of hierarchical modeling—now commonplace in Bayesian data analysisA new chapter on Bayesian design that emphasizes Bayesian clinical trialsA completely revised and expanded section on ranking and histogram estimationA new case study on infectious disease modeling and the 1918 flu epidemicA solutions manual for qualifying instructors that contains solutions, computer code, and associated output for every homework problem—available both electronically and in printIdeal for Anyone Performing Statistical Analyses Focusing on applications from biostatistics, epidemiology, and medicine, this text builds on the popularity of its predecessors by making it suitable for even more practitioners and students.