Harold Gainer – författare
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2 produkter
2 produkter
1 492 kr
Skickas inom 11-20 vardagar
Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems.The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers• Both print and enhanced e-book versions are available• Illustrated in full colour throughoutThis is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA
942 kr
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Elucidation of the important roles played by peptides as hypothalamic-adenohypo- physeal releasing factors, or regulatory hormones, has in recent years led to the recognition that peptides may also be of significance as intercellular messengers in other regions of the nervous system. In this regard, it is interesting that Sub- stance P, which has been proposed as a putative neurotransmitter in the spinal cord, was rediscovered by Leeman and her co-workers during their search for the corticotropin-releasing factor in the hypothalamus. Indeed, with the wide- spread availability and use of radioimmunoassay techniques, it has become ap- parent that various "hypothalamic releasing factors" are localized in extrahypo- thalamic areas of the central nervous system as well. This book represents an expression of the belief that the impact on neurobiology of research into neuro- peptides will be comparable to, if not greater than, the recent achievements obtained with the biogenic amines. As already appears to be the case, future inves- tigations on brain pep tides will undoubtedly uncover a host of new transmitter candidates, with obvious implications for neuropharmacology.Perhaps the most dramatic developments in this field have been the discoveries of the endogenous opiate peptides (enkephalin and endorphin), and the profound physiological and behavioral effects of specific peptides.