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35 produkter
35 produkter
Inbunden, Engelska, 2015
1 021 kr
Skickas inom 10-15 vardagar
The Linguistic Cerebellum provides a comprehensive analysis of this unique part of the brain that has the most number of neurons, each operating in distinct networks to perform diverse functions.
This book outlines how those distinct networks operate in relation to non-motor language skills. Coverage includes cerebellar anatomy and function in relation to speech perception, speech planning, verbal fluency, grammar processing, and reading and writing, along with a discussion of language disorders.
Discusses the neurobiology of cerebellar language functions, encompassing both normal language function and language disorders Includes speech perception, processing, and planning Contains cerebellar function in reading and writing Explores how language networks give insight to function elsewhere in the brain
E-bok
Engelska, 20151 083 kr
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The Linguistic Cerebellum provides a comprehensive analysis of this unique part of the brain that has the most number of neurons, each operating in distinct networks to perform diverse functions.This book outlines how those distinct networks operate in relation to non-motor language skills. Coverage includes cerebellar anatomy and function in relation to speech perception, speech planning, verbal fluency, grammar processing, and reading and writing, along with a discussion of language disorders.- Discusses the neurobiology of cerebellar language functions, encompassing both normal language function and language disorders- Includes speech perception, processing, and planning- Contains cerebellar function in reading and writing- Explores how language networks give insight to function elsewhere in the brain
Häftad, Engelska, 2027
1 517 kr
Kommande
Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease.From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.Offers a diverse perspective on cerebellar motor control and its implications across disciplinesExplores real-world case studies and clinical vignettes to illustrate the practical application of cerebellar research in diagnosing, treating, and managing motor disordersProvides valuable insights into emerging areas of research and potential future developments in cerebellar neuroscience and rehabilitationCaters to a wide audience, including students, researchers, clinicians, and educators to help facilitate learning and understanding across various levels of expertise
E-bok
PDF, Engelska, 20122 105 kr
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Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
Häftad, Engelska, 2014
2 133 kr
Skickas inom 5-8 vardagar
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
E-bok
Engelska, 20194 066 kr
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A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Häftad, Engelska, 2020
3 590 kr
Skickas inom 5-8 vardagar
A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Inbunden, Engelska, 2021
2 000 kr
Skickas inom 10-15 vardagar
This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.
E-bok
Engelska, 20212 517 kr
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This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.
Häftad, Engelska, 2022
2 000 kr
Skickas inom 10-15 vardagar
This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.
Del 1378 - Advances in Experimental Medicine and Biology
Emotional Cerebellum
Inbunden, Engelska, 2022
2 157 kr
Skickas inom 10-15 vardagar
Emotions represent a critical aspect of daily life in humans. Our understanding of the mechanisms of regulation of emotions has increased exponentially these last two decades. This book evaluates the contribution of the cerebellum to emotion. It outlines the current clinical, imaging and neurophysiological findings on the role of the cerebellum in key aspects of emotional processing and its influence on motor and cognitive function and social behavior.In the first section, the reader is introduced to the contributions of the cerebellum to various emotion domains, from emotion perception and recognition to transmission and encoding. Subsequent chapters provide a comprehensive picture of the neurophysiology and topography of emotion in the cerebellum and illustrate the convergence of theoretical and empirical research. Additional chapters address the cerebellum's involvement in emotional learning, emotional pain, emotional aspects of body language and perception, and its relationsto social cognition including morality, music, and art. Finally, neuropsychiatric aspects of the cerebellum's influence on mood disorders and the current state of therapeutic options, including noninvasive stimulation approaches, complete the overview. This is the first book summarizing the current state of knowledge on the contribution of the cerebellum to important aspects of emotion. It is an essential reference for students, trainees, neuroscientists, researchers, and clinicians in neuroscience, neurology, neurosurgery and psychology involved in the study of emotions. The authors are renowned scientists in the field of cerebellar research.
E-bok
Engelska, 20222 833 kr
Läs direkt efter köp
Emotions represent a critical aspect of daily life in humans. Our understanding of the mechanisms of regulation of emotions has increased exponentially these last two decades. This book evaluates the contribution of the cerebellum to emotion. It outlines the current clinical, imaging and neurophysiological findings on the role of the cerebellum in key aspects of emotional processing and its influence on motor and cognitive function and social behavior.
In the first section, the reader is introduced to the contributions of the cerebellum to various emotion domains, from emotion perception and recognition to transmission and encoding. Subsequent chapters provide a comprehensive picture of the neurophysiology and topography of emotion in the cerebellum and illustrate the convergence of theoretical and empirical research. Additional chapters address the cerebellum''s involvement in emotional learning, emotional pain, emotional aspects of body language and perception, and its relationsto social cognition including morality, music, and art. Finally, neuropsychiatric aspects of the cerebellum''s influence on mood disorders and the current state of therapeutic options, including noninvasive stimulation approaches, complete the overview.
This is the first book summarizing the current state of knowledge on the contribution of the cerebellum to important aspects of emotion. It is an essential reference for students, trainees, neuroscientists, researchers, and clinicians in neuroscience, neurology, neurosurgery and psychology involved in the study of emotions. The authors are renowned scientists in the field of cerebellar research.
Del 1378 - Advances in Experimental Medicine and Biology
Emotional Cerebellum
Häftad, Engelska, 2023
2 157 kr
Skickas inom 10-15 vardagar
Emotions represent a critical aspect of daily life in humans. Our understanding of the mechanisms of regulation of emotions has increased exponentially these last two decades. This book evaluates the contribution of the cerebellum to emotion. It outlines the current clinical, imaging and neurophysiological findings on the role of the cerebellum in key aspects of emotional processing and its influence on motor and cognitive function and social behavior.In the first section, the reader is introduced to the contributions of the cerebellum to various emotion domains, from emotion perception and recognition to transmission and encoding. Subsequent chapters provide a comprehensive picture of the neurophysiology and topography of emotion in the cerebellum and illustrate the convergence of theoretical and empirical research. Additional chapters address the cerebellum's involvement in emotional learning, emotional pain, emotional aspects of body language and perception, and its relationsto social cognition including morality, music, and art. Finally, neuropsychiatric aspects of the cerebellum's influence on mood disorders and the current state of therapeutic options, including noninvasive stimulation approaches, complete the overview. This is the first book summarizing the current state of knowledge on the contribution of the cerebellum to important aspects of emotion. It is an essential reference for students, trainees, neuroscientists, researchers, and clinicians in neuroscience, neurology, neurosurgery and psychology involved in the study of emotions. The authors are renowned scientists in the field of cerebellar research.
Häftad, Engelska, 2008
395 kr
Skickas inom 10-15 vardagar
Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained. This book has been written for biomedical engineering students, engineers, researchers, medical students, biologists, neurologists, and biomedical professionals of any discipline looking for an updated and multidisciplinary overview of tremor. It can be used for biomedical courses. Table of Contents: Introduction / Anatomical Overview of the Central and Peripheral Nervous System / Physiology of the Nervous System / Characterization of Tremor / Prinipal Disorders Associated with Tremor / Quantification of Tremor / Mechanisms of Tremor / Treatments
E-bok
PDF, Engelska, 2022489 kr
Läs direkt efter köp
Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained. This book has been written for biomedical engineering students, engineers, researchers, medical students, biologists, neurologists, and biomedical professionals of any discipline looking for an updated and multidisciplinary overview of tremor. It can be used for biomedical courses. Table of Contents: Introduction / Anatomical Overview of the Central and Peripheral Nervous System / Physiology of the Nervous System / Characterization of Tremor / Prinipal Disorders Associated with Tremor / Quantification of Tremor / Mechanisms of Tremor / Treatments
Inbunden, Engelska, 2022
974 kr
Skickas inom 10-15 vardagar
Historically researchers of neuroscience and psychology have believed that the cerebral cortex produces the unique mental capacities of human beings. However, a prevalence of brain-imaging evidence now shows that the cerebral cortex, while the seat of our everyday experience (notably in working memory), is not predominant in actually formulating our amazing capabilities. Rather, the achievements that mark humans as “Homo sapiens” originate in the cerebellum which increased three- to fourfold in size and acquired massive cognitive and social optimization capabilities over the last million years. Thus, through its optimization of experience and skill of the cerebral cortex, it was the cerebellum that was and is predominant in producing culture, language, mathematics, creativity, and extreme levels of skill in all areas from sports to computer science and art. These optimizing functions of the cerebellum are shown in the cases of Albert Einstein, Wolfgang Amadeus Mozart, Maryam Mirzakhani, and the predictive powers of Stonehenge.This book fills a critical role in bringing courses up-to-date with the profound, basic changes this newly understood predominant role of the cerebellum provides for understanding the mechanisms related to all topics in psychology and neuroscience. It is critical that this “new revolution in psychology and the neurosciences” be introduced and reviewed in courses that are part of both undergraduate and graduate studies in psychology and neuroscience. This text might also be of use to courses in anthropology and cross-disciplinary studies as the cerebellum was critically involved in the evolution of cognitive and social behaviour.
E-bok
Engelska, 2022868 kr
Läs direkt efter köp
Historically researchers of neuroscience and psychology have believed that the cerebral cortex produces the unique mental capacities of human beings. However, a prevalence of brain-imaging evidence now shows that the cerebral cortex, while the seat of our everyday experience (notably in working memory), is not predominant in actually formulating our amazing capabilities. Rather, the achievements that mark humans as “Homo sapiens” originate in the cerebellum which increased three- to fourfold in size and acquired massive cognitive and social optimization capabilities over the last million years. Thus, through its optimization of experience and skill of the cerebral cortex, it was the cerebellum that was and is predominant in producing culture, language, mathematics, creativity, and extreme levels of skill in all areas from sports to computer science and art. These optimizing functions of the cerebellum are shown in the cases of Albert Einstein, Wolfgang Amadeus Mozart, Maryam Mirzakhani, and the predictive powers of Stonehenge.
This book fills a critical role in bringing courses up-to-date with the profound, basic changes this newly understood predominant role of the cerebellum provides for understanding the mechanisms related to all topics in psychology and neuroscience. It is critical that this “new revolution in psychology and the neurosciences” be introduced and reviewed in courses that are part of both undergraduate and graduate studies in psychology and neuroscience. This text might also be of use to courses in anthropology and cross-disciplinary studies as the cerebellum was critically involved in the evolution of cognitive and social behaviour.
Häftad, Engelska, 2023
706 kr
Skickas inom 10-15 vardagar
Historically researchers of neuroscience and psychology have believed that the cerebral cortex produces the unique mental capacities of human beings. However, a prevalence of brain-imaging evidence now shows that the cerebral cortex, while the seat of our everyday experience (notably in working memory), is not predominant in actually formulating our amazing capabilities. Rather, the achievements that mark humans as “Homo sapiens” originate in the cerebellum which increased three- to fourfold in size and acquired massive cognitive and social optimization capabilities over the last million years. Thus, through its optimization of experience and skill of the cerebral cortex, it was the cerebellum that was and is predominant in producing culture, language, mathematics, creativity, and extreme levels of skill in all areas from sports to computer science and art. These optimizing functions of the cerebellum are shown in the cases of Albert Einstein, Wolfgang Amadeus Mozart, Maryam Mirzakhani, and the predictive powers of Stonehenge.This book fills a critical role in bringing courses up-to-date with the profound, basic changes this newly understood predominant role of the cerebellum provides for understanding the mechanisms related to all topics in psychology and neuroscience. It is critical that this “new revolution in psychology and the neurosciences” be introduced and reviewed in courses that are part of both undergraduate and graduate studies in psychology and neuroscience. This text might also be of use to courses in anthropology and cross-disciplinary studies as the cerebellum was critically involved in the evolution of cognitive and social behaviour.
Inbunden, Engelska, 2023
1 619 kr
Skickas inom 10-15 vardagar
This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
1 578 kr
Läs direkt efter köp
This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas.
There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia.
Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
Häftad, Engelska, 2024
1 189 kr
Skickas inom 10-15 vardagar
This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
Inbunden, Engelska, 2023
2 553 kr
Skickas inom 10-15 vardagar
Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
E-bok
Engelska, 20233 250 kr
Läs direkt efter köp
Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
665 kr
Skickas inom 5-8 vardagar
Häftad, Engelska, 2024
2 553 kr
Skickas inom 10-15 vardagar
Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
Inbunden, Engelska, 2023
2 221 kr
Skickas inom 10-15 vardagar
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
E-bok
Engelska, 20232 917 kr
Läs direkt efter köp
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
Häftad, Engelska, 2024
2 221 kr
Skickas inom 10-15 vardagar
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
5 230 kr
Skickas inom 10-15 vardagar
This Springer Major Reference Work provides a detailed translational overview of neuroimmune diseases for neuroscientists and clinicians, clarifying the pathological mechanisms underlying neuroimmune diseases and building a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The new edition features updated chapters throughout, including coverage of new findings, new diagnostic criteria, and therapeutic algorithms. Neuroimmune Diseases, 2nd edition, also includes new chapters with a translational approach. The book will be invaluable for use in clinical practice of neuroimmune diseases.
E-bok
Engelska, 20245 687 kr
Läs direkt efter köp
This Springer Major Reference Work provides a detailed translational overview of neuroimmune diseases for neuroscientists and clinicians, clarifying the pathological mechanisms underlying neuroimmune diseases and building a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The new edition features updated chapters throughout, including coverage of new findings, new diagnostic criteria, and therapeutic algorithms. Neuroimmune Diseases, 2nd edition, also includes new chapters with a translational approach. The book will be invaluable for use in clinical practice of neuroimmune diseases.