Noriyuki Koibuchi - Böcker
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9 produkter
9 produkter
2 793 kr
Skickas inom 10-15 vardagar
Advances in Biomolecular Medicine contains the selected papers presented at the 4th BIBMC (Bandung International Biomolecular Medicine Conference) and the 2nd ACMM (ASEAN Congress on Medical Biotechnology and Molecular Biosciences), hosted by the Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia, 4-6 October 2016. In line with the United Nations Sustainable Development Goals, the theme of the joint scientific meeting is ‘Medical innovation & translational research to ensure healthy lives & promote well-being for all at all ages’. Authors include scientists, academics, practitioners, regulators and other key individuals with expertise and experience relevant to biomolecular medicine, medical biotechnology and molecular biosciences. Topics of the papers cover various aspects of infection, oncology, tuberculosis, genetics, thalassemia, nutrition, cardiovascular, wound healing and endocrinology. This book is essential reading for academics, scientist, practitioners and regulators involved in the area of biomolecular medicine, medical biotechnology and molecular biosciences.
1 858 kr
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Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.
1 858 kr
Skickas inom 10-15 vardagar
An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals.
12 847 kr
Skickas inom 10-15 vardagar
Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing.
Essentials of Cerebellum and Cerebellar Disorders
A Primer For Graduate Students
Inbunden, Engelska, 2023
1 593 kr
Skickas inom 10-15 vardagar
Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology.
631 kr
Skickas inom 5-8 vardagar
Essentials of Cerebellum and Cerebellar Disorders
A Primer For Graduate Students
Häftad, Engelska, 2024
1 170 kr
Skickas inom 10-15 vardagar
Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology.
Essentials of Cerebellum and Cerebellar Disorders
A Primer For Graduate Students
Häftad, Engelska, 2018
845 kr
Skickas inom 10-15 vardagar
Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology.
6 428 kr
Skickas inom 10-15 vardagar
Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.