Roles of the Cerebellum in Motor Control

Dr. Mario Manto is a Neurologist at the Université Libre de Bruxelles (Belgium) with more than 20 years of experience in clinical neurology, particularly cerebellar ataxia. He is a Professor of Neuroanatomy at the University of Mons (Belgium) and Researcher at the FNRS (Belgium). He has been appointed Head of the Department of Neurology of the Centre Hospitalier Universitaire (CHU) de Charleroi (Belgium). The focus of his career for more than 20 years has been the study of cerebellar disorders, from a clinical and basic science point of view. He published more than 160 peer reviewed scientific articles and 15 book chapters on cerebellar topics and he is the editor of 6 books on cerebellar disorders. He is the Founding Editor and Editor in chief of two scientific journals: The Cerebellum and Cerebellum & Ataxias. He is Deputy Editor of the Journal of Neuroengineering and Rehabilitation and a Member of Faculty 1000. He has received many grants from several foundations including the NIH, European Commission, and the Fonds National de la Recherche Scientifique of Belgium. Dr. Timmann received her medical degree from the University of Tübingen, Germany. She is a board-certified neurologist. She was a postdoctoral researcher at the R.S. Dow Neurological Sciences Institute (Dr. F.B. Horak), Portland, USA, at the Arizona State University, Tempe and Barrow Neurological Institute (Dr. J. Bloedel), Phoenix, USA, and at the Dept. of Physiology (Dr. J. Hore), University of Western Ontario, London, Canada. She was a visiting scholar at the Human Sensorimotor Control Laboratory (Dr. J. Konczak), University of Minnesota, Minneapolis, MN, USA.Dr. Timmann’s research areas are the physiology and pathophysiology of the human cerebellum with a focus on human cerebellar lesion studies, lesion-behavior (“symptom”)-mapping, ataxias, structural and functional MRI of the cerebellum and cerebellar nuclei. She is an Associate Professor of Experimental Neurology at the Department of Neurology, University Hospital Essen, University of Duisburg-Essen. Dr. Timmann is head of the Ataxia Clinic, Department of Neurology, University Hospital Essen. She is currently vice speaker of the Collaborative Research Center SFB 1280 “Extinction learning”. Research Director INSERM, MSc quantum physics MSc molecular pharmacology, PhD Pasteur Institute, postdoc MIT

• SECTION 1. Experimental approaches: from single neurons to networks1. The olivocerebellar somatotopy2. Cerebellum-brainstem loops3. Fastigial nuclei: inputs/outputs4. Complex spikes5. Memory of motor learning6. Motor prediction and feedback in Purkinje cell activity.7. synchrony in cerebellar cortico-nuclear interactions8. LTD9. Predictive computations10. Cellular imaging of cerebello-cerebral interactions11. Intermodular integration in the cerebellar cortex for motor control12. Cerebellar contribution to the development of sensorimotor circuits13. Error processing in the cerebellar cortex14. Mechanistic and Functional Diversity in Cerebello - Cerebral Coupling15. Cerebellum-basal ganglia interactionsSECTION 2. From sensors to digital assessment of motion16. digital gait biomarkers / wearables / cerebellar gait / rehab17. Wearable sensors for upper limbs18. Camera-based analysis19. Gait20. Machine learningSECTION 3. Neuroimaging21. Imaging of the motor cerebellum / circuits22. Cerebellum and tremor: neuroimaging aspects23. Functional connectivity24. The cerebellar connectome25. Structure-function relations in dystonia26. Functional organization and perturbation of the cerebellumSECTION 4. Physiology and pathophysiology of motion27. Cerebellar control of timing and eye saccade28. Cerebello-cerebral circuit in motor control and preparation29. Sensorimotor integration of proprioception30. Cerebellum in reaching movement31. Cortico-cerebellar loops in reaching movement32. timing behind motor control33. Neurophysiology of cerebellar motor control in NHP34. cerebellar control of locomotion35. Occulomotor reflexes36. Cerebellar cortico-nuclear interactions in eyeblink conditioning37. Neurophysiology of cerebellum in tremor38. Cerebellum and Parkinson’s diseaseSECTION 5. Research and clinical implications: from the lab to the rehabilitation39. Cerebellar dysfunction and rehabilitation40. Cerebellar-based therapies of motor dysfunction41. cerebellum and fatigue42. non-invasive cerebellar stimulation / rehab43. Cerebellar reserve