William F. Rosenberger – författare
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2 produkter
2 produkter
Del 525 - Wiley Series in Probability and Statistics
Theory of Response-Adaptive Randomization in Clinical Trials
Inbunden, Engelska, 2006
1 776 kr
Skickas inom 5-8 vardagar
Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures.This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power?Can standard inferential tests be applied following response-adaptive randomization?What is the effect of delayed response?Which procedure is most appropriate and how can "most appropriate" be quantified?How can heterogeneity of the patient population be incorporated?Can response-adaptive randomization be performed with more than two treatments or with continuous responses?The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomizationThe general result for determining asymptotically best proceduresProcedures based on urn modelsProcedures based on sequential estimationImplications for the practice of clinical trialsUseful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.
Inbunden, Engelska, 2016
1 416 kr
Skickas inom 5-8 vardagar
Praise for the First Edition“All medical statisticians involved in clinical trials should read this book…”- Controlled Clinical TrialsFeaturing a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians.Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trialsA new chapter on covariate-adaptive randomization, including minimization techniques and inferenceNew developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization testsPlenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understandingRandomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics.William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley.John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.