Handbook of Psychopharmacology – serie
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Volume 18 of the Handbook of Psychopharmacology represents the first of a series of volumes intended to bring earlier sections of the work up to date. Volumes 7, 8, and 9, published in 1977 and 1978, dealt with principles of behavior, drugs and neurotransmitters, and neuroanatomy. In subsequent volumes dedicated to these issues, a mixture of topics will be covered in a given volume, covering both advances in basic knowledge in these three areas of the subject and reviews of theoretical and meth odological issues deemed to be of particular relevance at present. L. L. !. S. D. !. S. H. S. vii CONTENTS CHAPTER 1 Behavior as a Measure of Adverse Responses to Environmental Contaminants BERNARD WEISS 1. Special Perspectives 1 1. 1. Pharmacology and Toxicology . . . . . . . . . . . . . . 1 1. 2. Origins of Behavioral Toxicology . . . . . . . . . . . . 2 1. 3. Special Problems 2 2. Specific Substances . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 1. Heavy Metals 5 2. 2. Volatile Solvents 20 2. 3. Pesticides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 2. 4. Air Pollutants 36 2. 5. Nonspecific Poisons . . . . . . . . . . . . . . . . . . . . . . 42 2. 6. Food Additives 44 3. Future Prospects 47 3. 1. Chemical Waste . . . . . . . . . . . . . . . . . . . . . . . . . 47 3. 2. Susceptible Populations . . . . 48 3. 3. The Statistics of Risk . . . . . . . . . . . . . . . . . . . . . 49 3. 4. Screening 49 3. 5. Implications for Psychopharmacology 51 4. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 CHAPTER 2 State Dependent Learning and Drug Discriminations DONALD A. OVERTON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 2. Description of State Dependent Learning . . . . . . . . . . 59ix x CONTENTS 3. History of Development of Knowledge about SDL 60 3. 1. Nineteenth Century Reports. . . . . . . . . . . . . . . .
Del 1 - Handbook of Psychopharmacology
Biochemical Principles and Techniques in Neuropharmacology
Häftad, Engelska, 2012
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It is difficult to imagine an era in which there were no selective drugs for treating anxiety, depression, schizophrenia, and other mental ailments. Yet in a remarkably short time these drugs have come to occupy a position of prominence in medical practice throughout the world, and they now account for a major portion of all prescriptions. Most psychotropic drugs were discovered with little premeditation on the part of the inves~ tigator. The drugs simply "worked," often with little rationale, and psychopharmacology has been for many years an empirical discipline in search of scientific underpinnings. In the past decade, a basic science of psychopharmacology has de veloped and grown rapidly. Though psychotropic drugs are exceedingly "young" as drugs in medical practice go, we probably know more about their various mechanisms of action than we know about most drugs in clinical use. Advances in understanding effects of psychopharmaceuticals on the brain have been so prodigious that a new research paradigm has evolved. Instead of being concerned solely with understanding how the drugs act, many researchers now employ psychotropic drugs as tools-often the most powerful ones-to elucidate brain function. Consequently, psychophar macology is central to neurobiology, which in turn has emerged as an important discipline, heir to the preeminent glamor of molecular biology.
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527 kr
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527 kr
Skickas inom 10-15 vardagar
527 kr
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The first six volumes of the Handbook reviewed basic neuropharmacology, drawing on expertise in biochemistry, pharmacology and electrophysiology. The next three volumes focus attention on the functional importance of these basic neuropharmacological mechanisms for normal behavior. In order to study this interface in the intact functioning organism, appropriate methods for describing and quantifying behavior must be developed. The past twenty years have witnessed a revolution in the study of behavior which has taken us away from the often fruitless theoretical arguments to descriptive behaviorism. Technical achievements in the design of apparatus and the recording of behavior played an important role in these and the resultant behavioral methods have been accepted and developments, found useful in studying the effects of drugs. The development of psycho pharmacology as a discipline owes as much to these behavioral methods as it does to the basic neuropharmacological techniques pioneered for in vitro studies. In the first section of Volume 7, an effort has been made to provide reviews both of theory and practice in behavioral science. Milner's chapter deals with the concept of motivation in a theoretical framework. By contrast, the chapters by Morse et ai. and Dews and DeWeese provide a more descriptive view of the various ways in which aversive stimuli control behavior and the importance of schedules of reinforcement in determining the profile of responding in the animal. The equal importance of observational behav ioral methods is well illustrated by Mackintosh et ai.
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The first six volumes of the Handbook reviewed basic neuropharmacology, drawing on expertise in biochemistry, pharmacology and electrophysiology. The next three volumes focus attention on the functional importance of these basic neuropharmacological mechanisms for normal behavior. In order to study this interface in the intact functioning organism, appropriate methods for describing and quantifying behavior must be developed. The past twenty years have witnessed a revolution in the study of behavior which has taken us away from the often fruitless theoretical arguments to descriptive behaviorism. Technical achievements in the design of apparatus and the recording of behavior played an important role in these developments, and the resultant behavioral methods have been accepted and found useful in studying the effects of drugs. The development of psycho pharmacology as a discipline owes as much to these behavioral methods as it does to the basic neuropharmacological techniques pioneered for in vitra studies. In the first section of Volume 7, an effort has been made to provide reviews both of theory and practice in behavioral science. Milner's chapter deals with the concept of motivation in a theoretical framework. By contrast, the chapters by Morse et at. and Dews and DeWeese provide a more descriptive view of the various ways in which aversive stimuli control behavior and the importance of schedules of reinforcement in determining the profile of responding in the animal. The equal importance of observational behav ioral methods is well illustrated by Mackintosh et at.
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Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas such as "The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Be havior" and "Peptides and the Central Nervous System. " Surveying these diverse contributions, one comes away with a sentiment that, far from being an "applied" science borrowing from fundamental brain chemistry and physiology, psychopharmacology has instead provided basic researchers with the tools and conceptual approaches which now are advancing neurobiology to a central role in modern biology. Especially gratifying is the sense that, while contributing to an understanding of how the brain functions, psychopharmacology is a discipline whose fruits offer genuine help to the mentally ill with promises of escalating benefits in the future. L. L. 1. S. D. I. S. H. S. VII CONTENTS CHAPTER 1 Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs Roy PICKENS, RICHARD A. MEISCH, and TRAVIS THOMPSON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I 2. Methods of Self-Administration . . . . . . . . . . . . . . . . . . . . . . . 3 3. Establishing Drugs as Reinforcers. . . . . . . . . . . . . . . . . . . . . . 4 4. Characteristics of Self-Administration . .. . . . . . . . . . . . . . . . 7 4. 1. Ethanol. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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It is now eight years since the first Handbook volumes on Basic Neuro pharmacology were published, and there have been many important advances. As in many other areas in science, progress in this field has depended to a considerable extent on the availability of new experimental methods, and Volume 15 reviews some major recent developments, including new autoradiographic techniques that allow direct visualization of drug and transmitter receptors in the nervous system, and the pin pointing of the precise locations of the changes in brain metabolism elicited by various drug treatments. Volume 16 and 17 cover two of the most active areas for basic research in psychopharmacology at the moment: the characterization of drug and transmitter receptors in brain by radioligand binding techniques, and studies of the role of small peptides in brain function. The latter area, in particular, illustrates how rapidly progress continues to be made in basic research on the mechanisms of chemical communication within the nervous system. Eight years ago when the Handbook first appeared none of the opioid peptides (enkephalins and endorphins) had yet been identified. Since then a whole new area of basic biological research has focused on these substances, and in addition we know of more than thirty other neuropeptides with putative eNS trans mitter functions.
527 kr
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1 048 kr
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Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas such as "The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Be havior" and "Peptides and the Central Nervous System. " Surveying these diverse contributions, one comes away with a sentiment that, far from being an "applied" science borrowing from fundamental brain chemistry and physiology, psychopharmacology has instead provided basic researchers with the tools and conceptual approaches which now are advancing neurobiology to a central role in modern biology. Especially gratifying is the sense that, while contributing to an understanding of how the brain functions, psychopharmacology is a discipline whose fruits offer genuine help to the mentally ill with promises of escalating benefits in the future. L. L. 1. S. D. I. S. H. S. VII CONTENTS CHAPTER 1 Amphetamines: Structure-Activity Relationships J. H. BIEL and B. A. Bopp 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2: Effects of Biogenic Amines . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2. 1. Norepinephrine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2. Dopamine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52. 3. Serotonin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. Central Stimulatory Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3. 1. Phenethylamine Derivatives. . . . . . . . . . . . . . . . . . . . . .