Sungkyunkwan University Outstanding Research – serie

When Seon (Zen) Buddhism was first introduced to Korea around Korea’s late Silla and early Goryeo eras, the function of the “beopdang” (Dharma hall) was transfused to the lecture hall found in ancient Buddhist temples, establishing a pivotal area within the temple compound called the “upper monastic area.” By exploring the structural formation and dissolution of the upper monastic area, the author shows how Korea established its own distinctive Seon temples, unlike those of China and Japan, in the course of assimilating a newly-introduced foreign culture as its own. To accomplish this, the author analyzed the inscriptions on stone monuments which recorded the lives of eminent monks and also numerous excavated temple ruins. These analyses give us a new perspective on the evolution of the upper monastic area, which had the beopdang as its center, at a time when early Seon temples were being established under very adverse and unstable circumstances. The exploration of the spatial organization and layout of Korean Seon temple architecture has illuminated the continuity between Korean Buddhist temples of both the ancient and medieval eras.

When Seon (Zen) Buddhism was first introduced to Korea around Korea’s late Silla and early Goryeo eras, the function of the “beopdang” (Dharma hall) was transfused to the lecture hall found in ancient Buddhist temples, establishing a pivotal area within the temple compound called the “upper monastic area.” By exploring the structural formation and dissolution of the upper monastic area, the author shows how Korea established its own distinctive Seon temples, unlike those of China and Japan, in the course of assimilating a newly-introduced foreign culture as its own. To accomplish this, the author analyzed the inscriptions on stone monuments which recorded the lives of eminent monks and also numerous excavated temple ruins. These analyses give us a new perspective on the evolution of the upper monastic area, which had the beopdang as its center, at a time when early Seon temples were being established under very adverse and unstable circumstances. The exploration of the spatial organization and layout of Korean Seon temple architecture has illuminated the continuity between Korean Buddhist temples of both the ancient and medieval eras.

Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.