Biologic Markers In Reproductp

Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, National Research Council

• 1 Front Matter; 2 Executive Summary; 3 1. Report of the Oversight Committee; 4 I. Biologic Markers in Male Reproductive and Gametic Genetic Toxicology; 5 2. Introduction; 6 3. Clinical Evaluation of Male Infertility; 7 4. Biologic Markers of Testicular Function; 8 5. Biologic Markers of Epididymal Structure and Function; 9 6. Biologic Markers of Accessory Sex Organ Structure and Function; 10 7. Biologic Markers of Human Male Reproductive Health and Physiologic Damage; 11 8. Assessing Transmitted Mutations in Mice; 12 9. Markers for Measuring Germinal Genetic Toxicity and Heritable Mutations in People; 13 10. Conclusions and Recommendations; 14 II. Biologic Markers in Female Reproductive Toxicology; 15 11. Introduction; 16 12. Biologic Markers of Genetic Damage in Females; 17 13. Biologic Markers of Reproductive Development and Aging; 18 14. Biologic Markers of Nonconceptive Menstrual Cycles; 19 15. Developing Assays of Biologic Markers for Epidemiologic Studies: Experience with a Marker of Pregnancy and Early Loss; 20 16. Conclusions and Recommendations; 21 III. Biologic Markers of Toxicity during Pregnancy; 22 17. Introduction; 23 18. Molecular Biology: Developing DNA Markers of Genotoxic Effects; 24 19. Reproductive Immunology: Biologic Markers of Compromised Pregnancies; 25 20. Cell Biology: Identifying Biologic Markers Expressed during Early Pregnancy; 26 21. Physiologic Assessment of Fetal Compromise; 27 22. Biologic Markers of Exposure during Pregnancy: Pharmacokinetic Assessments; 28 23. Conclusions and Recommendations; 29 IV. Biologic Markers in Neurodevelopmental Toxicology; 30 24. Introduction; 31 25. Developmental Neurobiology of the Central Nervous System; 32 26. Morphologic, Neurochemical, and Behavioral Responses to Toxic Agents; 33 27. Methodologic Issues of Extrapolation from Animal Studies to Human Toxicant Exposure; 34 28. Lead as a Paradigm for the Study of Neurodevelopmental Toxicology; 35 29. Conclusions and Recommendations; 36 Appendix: Assessing the Validity of Biologic Markers: Alpha-Fetoprotein; 37 References; 38 Biographies; 39 Index