In this issue of Clinics in Chest Medicine, guest editors Dr. James M. Horowitz, Frances Mae West, Eugene Yuriditsky and John M. Moriarty bring their considerable expertise to the topic of Pulmonary Embolism. Leading experts provide in-depth discussions on pathophysiology of RV failure in PE; echocardiography and POCUS; advances in risk stratification; ICU management of hemodynamically Sig PE; catheter-based therapies; and more.