In this issue of Neurosurgery Clinics, guest editor Dr. Daniel M. Prevedello brings his considerable expertise to the topic of Pituitary Neuroendocrine Tumors. Neurosurgery plays a crucial role in the management of these tumors, with surgical precision essential due to the proximity of vital structures like the optic chiasm and cavernous sinus. In this issue, top experts explore various aspects of balancing effective tumor removal with preservation of pituitary and neurovascular function within a multidisciplinary treatment framework.